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| 1 | Giant primary angiosarcoma of the small intestine showing severe sepsis显示文摘Primary malignant tumors of the small intestine are rare,comprising less than 2%of all gastrointestinal tumors.An 85-year-old woman was admitted with fever of 40℃ and marked abdominal distension.Her medical history was unremarkable,but blood examination showed elevated inflammatory markers.Abdominal computed tomography showed a giant tumor with central necrosis,extending from the epigastrium to the pelvic cavity.Giant gastrointestinal stromal tumor of the small intestine communicating with the gastrointestinal tract or with superimposed infection was suspected.Because no improvement occurred in response to antibiotics,surgery was performed.Laparotomy revealed giant hemorrhagic tumor adherent to the small intestine and occupying the peritoneal cavity.The giant tumor was a solid tumor weighing 3490 g,measuring24 cm×17.5 cm×18 cm and showing marked necrosis.Histologically,the tumor comprised spindle-shaped cells with anaplastic large nuclei.Immunohistochemical studies showed tumor cells positive for vimentin,CD31,and factorⅧ-related antigen,but negative for c-kit and CD34.Angiosarcoma was diagnosed.Although no postoperative complications occurred,the patient experienced enlargement of multiple metastatic tumors in the abdominal cavity and died 42 d postoperatively.The prognosis of small intestinal angiosarcoma is very poor,even after volume-reducing palliative surgery. | Mizuna Takahashi Masanori Ohara Noriko Kimura Hiromitsu Domen Takumi Yamabuki Kazuteru Komuro Takahiro Tsuchikawa Satoshi Hirano Nozomu Iwashiro | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 2 | 肠道上皮样血管肉瘤2例临床病理观察显示文摘目的探讨肠道上皮样血管肉瘤临床病理特征、诊断、鉴别诊断及免疫组化表达特征。方法回顾性分析2例肠道上皮样血管肉瘤患者的临床病理资料,在光学显微镜下对其进行形态学观察,借助免疫组织化学进一步对上皮样血管肉瘤的特点进行分析。结果2例均发生在老年男性肠道。镜下见肿瘤细胞弥漫分布,瘤细胞呈上皮样形态,可见裂隙样结构及核旁空泡,空泡中可见红细胞。免疫组化,2例均表达CD31、ERG、Fli-1,其中1例CK点灶弱表达。结论肠道上皮样血管肉瘤是一种罕见的疾病,活检极易误诊为低分化癌等恶性肿瘤,正确的病理诊断是治疗的关键。 | 张天铭 徐鹏飞 漆楚波 岳君秋 樊利芳 | 2021 | 诊断病理学杂志2021，28，5： | 1 |
| 3 | 小肠血管肉瘤的诊治(附1例报告)显示文摘目的探讨小肠血管肉瘤的临床诊断及治疗方法。方法选择小肠血管肉瘤患者1例,结合该患者的临床资料并回顾国内外文献报道,分析小肠血管肉瘤临床表现、影像学表现、病理特点、治疗及预后。结果该患者因“反复上腹痛半年,加重3 d”入院,其临床表现不典型,上腹部增强CT检查示:十二指肠末端与空肠交界处管壁增厚,周围见增大淋巴结,小肠恶性肿瘤(?);胃窦壁稍增厚;左肾上腺增粗。全麻下行腹腔镜探查术,切除病变小肠,远端空肠与十二指肠降部侧侧吻合。肿瘤大体形态:切除肠管内可见一溃疡型肿物8.0 cm×3.0 cm×1.5 cm,另可见3个菜花型肿物,大小分别为6.2 cm×2.5 cm×0.5 cm、7.5 cm×2.5 cm×0.8 cm、9.0 cm×2.8 cm×0.9 cm,肿物切面灰白、灰红,质软,肉眼见局部累及深肌层,局部向浆膜面突出生长。病理检查结果:十二指肠末端、空肠富于血管的短梭形细胞肿瘤,核分裂易见,伴较多坏死,倾向为恶性间叶性肿瘤,侵及浆膜层。无脉管、神经侵犯,两切缘未见肿瘤累及,肠系膜淋巴结未见转移性肿瘤。免疫组化检测结果:CD31阳性、ETS相关基因蛋白阳性、Friend白血病病毒插入位点1蛋白阳性、广谱细胞角蛋白阴性、低分子质量细胞角蛋白阴性、CD117阴性、胃肠道间质瘤特异性蛋白阴性、平滑肌肌动蛋白部分阳性、S100钙结合蛋白散在阳性、细胞骨架Desmin蛋白阴性、细胞角蛋白7阴性、细胞角蛋白20阴性、嗜铬粒蛋白A阴性、CD56阴性、突触核蛋白阴性、组织细胞增殖核抗原阳性(80%),符合血管肉瘤诊断,低分化。结论小肠血管肉瘤临床表现不典型,术前诊断困难,诊断主要依赖组织病理学和免疫组化,手术是其首选治疗方法。 | 路鹰鹏 赵文星 马红钦 刘利 王骥 | 2020 | 山东医药2020，60，1： | 0 |
| 4 | 胃原发性上皮样血管肉瘤1例报道显示文摘血管肉瘤是罕见的软组织肿瘤,占所有软组织肉瘤的1%~2%[1]。可发生于身体任何部位,但常见于皮肤和浅表的软组织,尤其是老年人头颈部,其次是四肢[2]。消化道血管肉瘤极为罕见。本文报道1例原发于胃的血管肉瘤并结合文献复习,探讨本病的临床病理特点、鉴别诊断及预后。1材料与方法1.1临床资料患者男性,60岁。因腹痛不适入院,查体无明显异常。 | 周宁 谭晓姝 陈俐巧 蔡晚霞 龙凤 伏阳燕 | 2016 | 诊断病理学杂志2016，23，12： | 0 |
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