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| 1 | HIV感染者中富马酸替诺福韦酯抗HBV的功效显示文摘Tenofovir disoproxil fumarate(TDF)has shown in vitro activity against both HIV and hepatitis B virus(HBV).We retrospectively evaluated the efficacy of TDF(300 mg/d),administered as a part of anti-retroviral therapy,in a large cohort of HIV/HBVcoinfected patients.Sixty-five HIV/HBV-coinfected patients who received TDF for at least 6 months with serum HBV DNA levels above 2.3 log10 copies/mL at TDF initiation and who had stored serum samples before and during TDF therapy were included.Serum HBV DNA was measured on stored samples.The median follow-up period was 12(Q1-Q3:8-17)months.Serum hepatitis B e antigen(HBeAg)was positive in 54 patients(83.1%).Fifty-two patients(80.0%)were receiving lamivudine(LAM)(150 mg twice a day),and 68.8%had documented LAM resistance at baseline.Among HBeAg positive patients,the median reduction from baseline(8.17;Q1-Q3 = 7.30-8.30 log10copies/mL)of serum HBV DNA was 4.56 log10 copies/mL(Q1-Q3 = 3.33-5.55)(P <.0001).In HBeAg-negative patients,serum HBV DNA decline from baseline(4.83;Q1-Q3 = 2.69-6.40 log10 copies/mL)was 2.53 log10 copies/mL(Q1-Q3 = 0.39-4.10).At the end of the study,HBV DNA became undetectable in 29.6%and 81.6%of the HBeAg positive and HBeAg-negative patients,respectively.Serum HBeAg became negative in 4 patients,2 of whom acquired serum hepatitis B e antibody.In conclusion,this retrospective analysis demonstrates the efficacy of TDF against wild-type,presumed precore mutants and LAM-resistant HBV when used as a part of anti-retroviral therapy in HIV-coinfected patients. | Benhamou Y Fleury H. Trimoulet P. 陈云茹(译) 史敏(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 2 |
| 2 | Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients显示文摘 | Benhamou Y Fleury H Trimoulet P | 2006 | Hepatology2006，43，3： | 1 |
| 3 | PCR-detected hepatitis C virus RNA associated with human zona-intact oocytes collected from infected women for ART显示文摘 | Papaxanthos-Roche A Trimoulet P Commenges-Ducos M | 2004 | Hum Reprod2004，19，5： | 1 |
| 4 | Anti-hepatitis B virus efficaey of tenofovir disoproxil fumarate in HIV-infeet- ed patients显示文摘 | Benhamou Y Fleury H Trimoulet P | 2006 | Hepatology2006，43，6： | 1 |
| 5 | Predictive value of early HCV RNA quantitation for sustained response in nonresponders receiving daily interferon and ribavirin therapy显示文摘 | Trimoulet P Ledinghen V Foucher J | 2004 | J Med Virol2004，72，1： | 1 |
| 6 | Factors associated with DAA virological treatment failure and resistance-associated substitutions description in HIV/HCV coinfected patients显示文摘AIM To describe factors associated with treatment failure and frequency of resistance-associated substitutions(RAS).METHODS Human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients starting a first direct-acting antiviral(DAA) regimen before February 2016 and included in the French ANRS CO13 HEPAVIH cohort were eligible. Failure was defined as:(1) non-response [HCV-RNA remained detectable during treatment, at end of treatment(EOT)]; and(2) relapse(HCVRNA suppressed at EOT but detectable thereafter). Sequencing analysis was performed to describe prevalence of drug class-specific RAS. Factors associated with failure were determined using logistic regression models.RESULTS Among 559 patients, 77% had suppressed plasma HIV-RNA < 50 copies/mL at DAA treatment initiation, 41% were cirrhotic, and 68% were HCV treatmentexperienced. Virological treatment failures occurred in 22 patients and were mainly relapses(17, 77%) then undefined failures(3, 14%) and non-responses(2, 9%). Mean treatment duration was 16 wk overall. Posttreatment NS3, NS5 A or NS5 B RAS were detected in 10/14 patients with samples available for sequencing analysis. After adjustment for age, sex, ribavirin use, HCV genotype and treatment duration, low platelet count was the only factor significantly associated with a higher risk of failure(OR: 6.5; 95%CI: 1.8-22.6). CONCLUSION Only 3.9% HIV-HCV coinfected patients failed DAA regimens and RAS were found in 70% of those failing. Low platelet count was independently associated with virological failure. | Dominique Salmon Pascale Trimoulet Camille Gilbert Caroline Solas Eva Lafourcade Julie Chas Lionel Piroth Karine Lacombe Christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric Franoois Boué Philippe Morlat Isabelle Poizot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi Patrick Miailhes Firouzé Bani-Sadr Laure Esterle Patrizia Carrieri Franoois Dabis Philippe Sogni Linda Wittkop 无 | 2018 | World Journal of Hepatology2018，10，11： | 1 |
| 7 | Re-evaluation of anti-HBc non-reactive serum samples from patients with persistent hepatitis B infection by immune precipitation with labelled HBV core antigen显示文摘 | Vera C. Kantelhardt Alexandra Schwarz Ulrike Wend Christian G. Schüttler Wulf R. Willems Pascale Trimoulet Hervé Fleury Wolfram H. Gerlich Michael Kann | 2009 | Journal of Clinical Virology2009，，2： | 1 |
| 8 | Hepatitis C virus genotyping based on 5'nocoding sequence analysis(Trugene)显示文摘 | Halfon P Trimoulet P Bourliere M | 2001 | J Clin Microbiol2001，39，： | 1 |
| 9 | Hepatitis C virus genotyping based on 5 noncoding sequence analysis (Trugene) 显示文摘 | Halfon P Trimoulet P Bourliere M | 2001 | J Clin Microbiol2001，39，5： | 1 |
| 10 | Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients显示文摘 | Benhamou Y Fleury H Trimoulet P | | 0，，： | 1 |
| 11 | Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients显示文摘 | Benhamou Y Fleury H Trimoulet P | | 0，，03： | 1 |
| 12 | Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation显示文摘 | B. Taton K. Moreau S. Lepreux T. Bachelet P. Trimoulet V. De Ledinghen A. Pommereau P. Ronco N. Kamar P. Merville L. Couzi | 2013 | Transpl Infect Dis2013，，6： | 1 |
| 13 | Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV -infected patients显示文摘 | Benhamou Y Fleury H Trimoulet P | 2006 | Hepatology2006，43，3： | 1 |
| 14 | PCR-detected hepatitis C viru RNA associated with human zona-intact oocytes collected from infected women for ART显示文摘 | PAPAXANTHOS-ROCHE A TRIMOULET P COMMENGES-DUCOS M | 2004 | Hum Reprod2004，19，5： | 1 |
| 15 | Hepatitis B virus genotypes : a retrospective survey in Southwestern France, 1999-2004显示文摘 | Pascale Trimoulet Mathieu Boutonnet Maria Winnock Muriel Faure Marc-Arthur Loko Victor De Lédinghen Pierre-Henri Bernard Laurent Castéra Juliette Foucher Michel Dupon Jean-Marie Ragnaud Marie-édith Lafon Patrice Couzigou Fran?ois Dabis Hervé Fleury Didier | 2007 | Gastroenterologie Clinique et Biologique2007，，12： | 1 |
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