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| 1 | Decreased serum essential and aromatic amino acids in patients with chronic pancreatitis显示文摘AIM:To investigate the influence of chronic pancreatitis(CP) on serum concentrations of amino acids.METHODS:Thirty-five male patients with alcoholic CP and 21 healthy male subjects were examined.Serum concentrations of amino acids were assayed by ionpair high-performance liquid chromatography with mass detection.RESULTS:Serum glutamate concentration was increased in CP patients as compared to controls.In contrast,serum concentrations of glutamine,histidine,tyrosine,proline,tryptophan and threonine were significantly decreased in CP patients.A trend towards decreasing concentrations of serum lysine,alanine,methionine and valine as well as for total serum amino acids was observed.The sum of aromatic and the sum of essential amino acid concentrations were significantly lower in CP patients than in controls.CONCLUSION:CP leads to decreased serum concentrations of several amino acids,such as essential and aromatic serum amino acids,most likely due to decreased exocrine function. | Krystian Adrych Marian Smoczynski Magdalena Stojek Tomasz Sledzinski Ewa Slominska Elzbieta Goyke Ryszard Tomasz Smolenski Julian Swierczynski | 2010 | World Journal of Gastroenterology2010，16，35： | 3 |
| 2 | Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis显示文摘AIM: To examine circulating growth factor concentrations in patients with acute pancreatitis(AP) and chronic pancreatitis(CP), and walled-off pancreatic necrosis(WOPN). METHODS: Forty patients with mild AP, 40 patients with alcoholic CP, 33 patients with WOPN and 40 healthy subjects were examined. Serum concentrations of platelet derived growth factor BB(PDGF-BB), transforming growth factor β-1(TGFβ-1), chemerin and high-mobility group box chromosomal protein 1(HMBG1) were assayed by enzyme linked immunosorbent assay.RESULTS: Patients with mild AP and those with WOPN had significantly lower serum levels of PDGF-BB compared to healthy subjects(4.0 ± 0.61 ng/mL vs 6.2 ± 0.76 ng/mL, P = 0.027, and 1.60 ± 0.31 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001, respectively), while CP was associated with higher serum levels of PDGF-BB(12 ± 1.3 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001). Circulating TGFβ-1 and chemerin levels were elevated in CP patients(57 ± 3.6 ng/mL vs 39 ± 3.6 ng/mL, P < 0.001 and 73 ± 7.2 ng/mL vs 48 ± 2.3 ng/mL, P < 0.001, respectively), but not in patients with AP and WOPN. No significant changes in serum HMBG1 levels were found either in patients with AP, WOPN or CP. CONCLUSION: The serum levels of some growth factors and cytokines differ significantly in AP, WOPN and CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases. | Magdalena Stojek Krystian Adrych Lukasz Rojek Marian Smoczynski Tomasz Sledzinski Sylwia Szrok Julian Swierczynski | 2014 | World Journal of Gastroenterology2014，20，36： | 2 |
| 3 | Sequencing technologies and genome sequencing显示文摘 | Pareek CS Smoczynski R Tretyn A | | 0，，04： | 1 |
| 4 | Routine brush cytology and fluorescence in situ hybridization for assessment of pancreatobiliary strictures 显示文摘 | Smoczynski M Jablonska A Matyskiel A | 2012 | Gastrointest Endosc2012，75，1： | 1 |
| 5 | The comparison of the use of cages with the use of autogenous bone grafts in the operative treatment of the isthmic spondylolisthesis by the posterior stabilisation and ALIF 显示文摘 | Pankowki R Smoczynski A Jaskolski D | 2009 | Clir Narzadow Ruchu Ortop Pol2009，74，1： | 1 |
| 6 | Se-quencing technologies and genome sequencing 显示文摘 | PAREEK C S SMOCZYNSKI R TRETYN A | 2011 | J Ap-pl Genet2011，52，4： | 1 |
| 7 | Sequencing technologies and genome sequencing显示文摘 | Pareek C S Smoczynski R Tretyn A | 2011 | J Appl Genet2011，52，4： | 1 |
| 8 | Composition and structure of the bovine milk fat globule membrane-some nutritional and technological implications 显示文摘 | Smoczynski M Staniewski B Kielczewska K | 2011 | Food Re- views International2011，28，2： | 1 |
| 9 | Increased Serum Resistin Concentration in Patients With Chronic Pancreatitis: Possible Cause of Pancreatic Fibrosis显示文摘 | Krystian Adrych Marian Smoczynski Tomasz Sledzinski Agnieszka Dettlaff-Pokora Elzbieta Goyke Julian Swierczynski | 2009 | Journal of Clinical Gastroenterology2009，，1： | 1 |
| 10 | Increased serum chemerin concentration in patients with chronic pancreatitis显示文摘 | Krystian Adrych Magdalena Stojek Marian Smoczynski Tomasz Sledzinski Szrok-Wojtkiewicz Sylwia Julian Swierczynski | 2011 | Digestive and Liver Disease2011，，5： | 1 |
| 11 | Increased serum chemerin concentration in patients with chronic pancreatitis显示文摘 | Adrych K Stojek M Smoczynski M | 2012 | Dig Liver Dis2012，44，5： | 1 |
| 12 | Novel O^6-methylguanine- DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden显示文摘 | Egyhazi S Ma S Smoczynski K | 2002 | Hum Mutat2002，20，5： | 1 |
| 13 | Decreased serum leptin concentration in patients with chronic pancreatitis 显示文摘 | Adrych K Smoczynski M Goyke E | 2007 | Pancreas2007，34，4： | 1 |
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