|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Survival of encapsulated islets: More than a membrane story显示文摘At present, proven clinical treatments but no cures are available for diabetes, a global epidemic with a huge economic burden. Transplantation of islets ofLangerhans by their infusion into vascularized organs is an experimental clinical protocol, the first approach to attain cure. However, it is associated with lifelong use of immunosuppressants. To overcome the need for immunosuppression, islets are encapsulated and separated from the host immune system by a permselective membrane. The lead material for this application is alginate which was tested in many animal models and a few clinical trials. This review discusses all aspects related to the function of transplanted encapsulated islets such as the basic requirements from a permselective membrane(e.g., allowable hydrodynamic radii, implications of the thickness of the membrane and relative electrical charge). Another aspect involves adequate oxygen supply, which is essential for survival/performance of transplanted islets, especially when using large retrievable macrocapsules implanted in poorly oxygenated sites like the subcutis. Notably, islets can survive under low oxygen tension and are physiologically active at > 40 Torr. Surprisingly, when densely crowded, islets are fully functional under hyperoxic pressure of up to 500 Torr(> 300% of atmospheric oxygen tension). The review also addresses an additional category of requirements for optimal performance of transplanted islets, named auxiliary technologies. These include control of inflammation, apoptosis, angiogenesis, and the intra-capsular environment. The review highlights that curing diabetes with a functional bio-artificial pancreas requires optimizing all of these aspects, and that significant advances have already been made in many of them. | Uriel Barkai Avi Rotem Paul de Vos | 2016 | World Journal of Transplantation2016，6，1： | 4 |
| 3 | Urinary cytokeratin 20 as a marker for transitional cell carcinoma显示文摘 | Rotem D Cassel A Lindenfeld N | 2000 | Eur Urol2000，37，5： | 1 |
| 4 | Alternatively spliced lysyloxidas-like 4 isoforms have a pro metastatic role in cancer显示文摘 | Shulamit S Golan gerstl R Rotem K | 2013 | ClinExp Metastasis2013，30，1： | 1 |
| 5 | Interactions of hydrophobic fractions of dissolved organic matter with Fe3+-and Cu2+-montmorillonite显示文摘 | Tamara P Yona C Rotem N | 2008 | Environmental Science & Technology2008，42，13： | 1 |
| 6 | Oxygen uptake rates in cultured hepatocytes显示文摘 | Rotem A Toner M Tompkins RG | 1992 | Biotechnol Bioeng1992，40，： | 1 |
| 7 | Improved antimicrobial peptides based on acyl-lysine oligomers显示文摘 | Radzishevsky IS Rotem S Bourdetsky D | 2007 | Nature Biotechnology2007，25，6： | 1 |
| 8 | Failure modes of angle-ply laminated显示文摘 | Rotem A Hashin Z | 1975 | Composite Materials1975，9，4： | 1 |
| 9 | Urinary cytokeratin 20 as a marker for transitional cell carcinoma 显示文摘 | Rotem D Cassel A Lindenfeld N | 2000 | Eur Urol2000，37，5： | 1 |
| 10 | PREDICTION OF LAMINATE FAILURE WITH THE ROTEM FAILURE CRITERION 1 This article represents the author’s contribution to a world-wide exercise to confirm the state-or-art for predicting in composites, organised by Hinton and Soden [10] . 1显示文摘 | A. Rotem | 1996 | Composites Science and Technology1996，，7： | 1 |
| 11 | A fatigue failure criterion for fiber reinforced materials 显示文摘 | Hashin Z Rotem A | 1973 | Journal of Composite Materials1973，7，4： | 1 |
| 12 | Fatigue failure criterion for fiber-reinforced materials显示文摘 | ttashin Z Rotem A | 1973 | Journal of Composite Materials1973，7，： | 1 |
| 13 | Determination of reinforcement unbonding of composites by a vibration technique显示文摘 | Lifshitz J M Rotem A | 1969 | Journal of Composite Materials1969，3，： | 1 |
| 14 | Free-edge effects in angle ply laminates: a new three dimensional finite difference solution 显示文摘 | Altus E Rotem A Shmueli M | 1980 | Journal of Composite Materials1980，14，： | 1 |
| 15 | Random sampling from databases: a survey显示文摘 | Frank Olken Doron Rotem | 1995 | Statistics and Computing1995，，1： | 1 |
| 16 | Biomechanical evaluation of the percutaneous compression plating system for hip fractures J显示文摘 | Gotfried Y Cohen B Rotem A | 2002 | J Orthop Trauma2002，16，9： | 1 |
| 17 | Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study 显示文摘 | Rotem C Kaplan B | 2007 | Gynecol Endocrinol2007，23，： | 1 |
| 18 | Aspirin enhances multidrugresistance gene ! expression in human Molt-4 T lymphoma cells显示文摘 | Flescher E Rotem R Kwon P | 2000 | Anticancer Res2000，20，6： | 1 |
| 19 | A fatigue failure criterion for fiber- reinforced composite materials 显示文摘 | Hashin Z Rotem A | 1973 | Journal of Composite Materials1973，7，： | 1 |
| 20 | Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line:Towards targeting of cancer stem cells with phytochemicals显示文摘 | Dunne Fong Arthur Yeh Rotem Naftalovich | 2010 | Cancer Let2010，293，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员