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| 1 | Antibiotic Resistance Genes in the Human-Impacted Environment:A One Health Perspective显示文摘Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains. | James M. TIEDJE WANG Fang Celia M. MANAIA Marko VIRTA SHENG Hongjie MA Liping ZHANG Tong Edward TOPP | 2019 | Pedosphere2019，29，3： | 11 |
| 2 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 3 | Combination cone penetration resistance/water content instrumentation to evaluate cone penetration-water content relationships in tillage research显示文摘 | Lapen D R Topp G C Edwards M E | 2004 | Soil and Tillage Research2004，79，1： | 1 |
| 4 | Laboratory calibration,in-field validation and use of a soil penetrometer measuring cone resistance and water content显示文摘 | Topp G C Lapen D R Edwards M J | 2003 | Vadose Zone Journal2003，2，4： | 1 |
| 5 | Polybrominateddiphenyl ethers,perfluorinated alkylated substances,andmetals in tile drainage and groundwater following applica-tions of municipal biosolids to agricultural fields显示文摘 | Gottschall N Topp E Edwards M | 2010 | Scienceof the Total Environment2010，408，4： | 1 |
| 6 | The effect of dietary inclusion of yeast culture (Yea2 Sacc) on patterns of rumen fermentation,food intake and growth of intensively-fed bulls 显示文摘 | Mutsvangwa T Edwards I E Topps J H | 1992 | Anita Prod1992，55，： | 1 |
| 7 | The effect ofdietary inclusion of yeast culture (Yea-Sacc) on patterns of ru-men fermentation, food intake and growth of intensively fedbulls显示文摘 | Mutsvangwa T Edwards I E Topps J H | 1992 | Anitn Prod1992，55，1： | 1 |
| 8 | 减少向环境中释放抗生素和抗生素耐药基因的管理措施显示文摘[背景]全球越来越关注污染土壤、水环境对抗生素耐药性产生和蔓延的作用。[目的]本研究的目的是确定那些可以减少抗生素和抗生素耐药性经环境途径传播影响因素的管理措施,以最终达到延长抗生素使用寿命的目标。此外还研究了实施这些措施的激励和阻碍因素。[方法]着重研究有关农业源头限制,生活、医院和工业废水处理,以及水产养殖三方面的管理措施。[讨论]我们确定了若干措施,如养份管理、径流控制和基础设施升级。凡适当处,可提供世界不同地区的典型实例。研究还强调了监测和验证管理策略有效性的重要性。最后,介绍了一则瑞典的案例研究,展示了通过沟通来发动利益相关方参与和促进行动的重要作用。[结论]在许多情况下,可以花费很少或根本不花费成本来减少抗生素和抗生素耐药性细菌的环境释放。一些管理措施与现有的政策和目标协同作用。预期的效益是延长现有和未来的抗生素使用寿命。虽然往往难以量化所降低的风险,但是全球抗生素耐药性相关发病率和死亡率加速增长,这一情况的严重程度强烈表明采取行动的必要性。 | Amy Pruden D.G.Joakim Larsson Alejandro Amézquita Peter Collignon Kristian K.Brandt David W.Graham James M.Lazorchak Satoru Suzuki Peter Silley Jason R.Snape Edward Topp Tong Zhang Yong-Guan Zhu 何蓉 汪源 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，1： | 1 |
| 9 | Theeffect of dietary inclusion of yeast culture(Yea sacc)on patterns of rumen fermentation,food intake andgrowth of intensively fed bulls显示文摘 | Mutsvangwa T Edwards I E Topps J H | 1992 | Anim Prod1992，55，： | 1 |
| 10 | Laboratory calibration,in-field validation and use of a soil penetrometer measuring cone resistance and water content显示文摘 | Topp G C Lapen D R Edwards M J | 2003 | Vadose Zone Journal2003，2，： | 1 |
| 11 | Physico-chemical characteristics and methanogen communities in swine and dairy manure storage tanks: Spatio-temporal variations and impact on methanogenic Activity 显示文摘 | Maialen Barret Nathalie Gagnon Edward Topp | 2013 | Water Research2013，，47： | 1 |
| 12 | Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field显示文摘 | Edwards M Topp E Metcalfe CD | 2009 | The Science of the Total Environment2009，407，14： | 1 |
| 13 | Selected Antimicrobial Resistance during Composting of Manure from Cattle Administered Sub-Therapeutic Antimicrobials显示文摘 | Sharma Ranjana Larney Francis J Chen Jing Yanke L Jay Morrison Mark Topp Edward McAllister Tim A Yu Zhongtang | 2009 | Journal of Environmental Quality2009，，2： | 1 |
| 14 | Impact of Manure Fertilization on the Abundance of Antibiotic-Resistant Bacteria and Frequency of Detection of Antibiotic Resistance Genes in Soil and on Vegetables at Harvest显示文摘 | Romain Marti Andrew Scott Yuan-Ching Tien Roger Murray Lyne Sabourin Yun Zhang Edward Topp | 2013 | Applied and Environmental Microbiology2013，，18： | 1 |
| 15 | The effect of dietary inclusion of yeast culture (Yea Sacc) on patterns of rumen fermentation, food intake and growth of intensively fed bulls 显示文摘 | Mutsvangwa T Edwards I E Topps J H | 1992 | Anita Prod1992，55，： | 1 |
| 16 | The response of limousine f riesian steers fed silage El sheikh and G F M paterson and concent rates to the addition of supplemental yeast culture (Yea-Sacc)and/ or an antibiotic additive(Avotan) 显示文摘 | Edwards 1 E Mut svangwa T J Topps H M | 1991 | Anim Prod1991，51，： | 1 |
| 17 | Evaluation of denaturing gradient gel electrophoresis in the detection of 16S rDNA sequence variation in rhizobia and methanotrophs显示文摘 | Tatiana Vallaeys Edward Topp Gerard Muyzer Valérie Macheret Gisèle Laguerre Annabel Rigaud Guy Soulas | 1997 | FEMS Microbiology Ecology1997，，3： | 1 |
| 18 | Bacterial community dynamics in liquid swine manure during storage: molecular analysis using DGGE/PCR of 16S rDNA显示文摘 | Leung Kam Topp Edward | 2001 | FEMS Microbiology Ecology2001，38，： | 1 |
| 19 | Combination cone penetration resistance/water content instru-mentation to evaluate cone penetration-water content relationships in tillage research显示文摘 | Lapen D R Topp G C Edwards M E | 2004 | Soil & Tillage Research2004，79，1： | 1 |
| 20 | Antibiotic Resistance and Diversity of Salmonella enterica Serovars Associated with Broiler Chickens显示文摘 | Diarra Moussa Sory Delaquis Pascal Rempel Heidi Bach Susan Harlton Colleen Aslam Mueen Pritchard Jane Topp Edward | 2014 | Journal of Food Protection2014，，1： | 1 |
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