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| 1 | 激光共焦显微成像的最新进展及其在生命科学研究中的应用显示文摘激光扫描共聚焦显微镜近年来得到了迅速发展,是近代最先进的细胞生物医学分析仪器之一。通过它可以对观察样品进行无创断层扫描和成像,在生物学和医学研究诊断的各个方面都得到了广泛的应用。本文主要介绍了激光扫描共焦显微镜的基本原理和发展状况,并着重介绍了在共焦荧光显微镜中采用薄荧光层和切片成像特性图来表征成像状态的功能。这种方法一般用于表征共聚焦和多光子显微镜的成像特性,是比较显微镜切片成像条件、成像质量等相关性能的重要依据。 | BRAKENHOFF GJ | 2009 | 生命科学2009，21，2： | 3 |
| 2 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 3 | Detection of rare disseminated tumor cells identifies head and neck cancer patients at risk of treatment failure显示文摘 | Partridge M Brakenhoff R Phillips E | 2003 | Clin Cancer Res2003，9，14： | 1 |
| 4 | Detection,clinical relevance and specific biological properties of disseminat- ing turnout cells 显示文摘 | Pantel K Brakenhoff RH Brandt B | 2008 | Nat Rev Cancer2008，8，5： | 1 |
| 5 | Detection,clinical relevance and specific biological properties of disseminating tumour cells显示文摘 | Pantel K Brakenhoff RH Brandt B | | 0，，05： | 1 |
| 6 | Persistence of genetically altered fields in head and neck cancer patients:biological and clinical implications显示文摘 | Tabor M P Brakenhoff R H Van Houten V M | 2001 | Clin Cancer Res2001，7，6： | 1 |
| 7 | Protein biomarker discovery for head and neck cancer显示文摘 | Schaaij-Visser TB Brakenhoff RH Leemans CR | 2010 | J Proteomics2010，73，10： | 1 |
| 8 | Detection,clinical relevance and specific biological properties of disseminating tumour cells显示文摘 | Pantel K Brakenhoff RH Brandt B | 2008 | Nat Rev Cancer2008，8，5： | 1 |
| 9 | Persistence of genetically altered fields in head and neck cancer patients:biological and clinical implications显示文摘 | Maarten P Tabor Ruud H Brakenhoff Viola M M van Houten | 2001 | Clinical Cancer Research2001，7，6： | 1 |
| 10 | Intracorporeal suture closure of the internal inguinal and vaginal rings in foals and horses显示文摘 | Caron JP Brakenhoff J | 2008 | Vet Surg2008，37，2： | 1 |
| 11 | Dissecting the metastatic cascade显示文摘 | Pantel K Brakenhoff RH | 2004 | Nat Rev Cancer2004，4，6： | 1 |
| 12 | Multiple head and neck tumors frequently originate from a single reneoplastic lesion显示文摘 | Tabor M P Brakenhoff R H Ruijter-Schippers H J | 2002 | Am J Pathol2002，161，： | 1 |
| 13 | 3- dimensional imaging of biological structures by high resolution confocal scanning laser microscopy 显示文摘 | Brakenhoff G J van der Voort H T van Spronsen E A | 1988 | Scan Microsc1988，2，1： | 1 |
| 14 | Detection of cytokeratin-19 transcripts by reverse transcriptase-polymerase chain reaction in lung cancer cell lines and blood of lung cancer patients显示文摘 | Dingemans AC Brakenhoff RH Postmus PE | 1997 | Lab Invest1997，77，3： | 1 |
| 15 | A highly conserved neutralizing epitope on group 2 influenza a viruses 显示文摘 | Ekiert D C Friesen R H Bhabha G Kwaks T Jon- geneelen M Yu W Ophorst C Cox F Korse H J Brandenburg B Vogels R Brakenhoff J P Kompier R Koldijk M H Cornelissen LA Poon L L Peiris M Koudstaal W Wilson IA Goudsmit J | 2011 | Science2011，333，6044： | 1 |
| 16 | Detection,clinical relevance and specific biological properties of disseminating tumour cells显示文摘 | pantel K Brakenhoff RH Brandt B | | 0，，05： | 1 |
| 17 | Multiple head and neck tumors frequently originate from a single preneoplastic lesion显示文摘 | Maarten P Tabor Ruud H Brakenhoff Henrique J RuijterSchippers | 2002 | American Journal of Pathology2002，161，3： | 1 |
| 18 | Detection,clinical rele-vance and specific biological properties of disseminating tumorcells显示文摘 | Pantel K Brakenhoff RH Brandt B | 2008 | Nat Rev Cancer2008，8，： | 1 |
| 19 | Detection, clinical relevanceand specific biological properties of disseminating tumour cells显示文摘 | Pantel K Brakenhoff RH Brandt B | 2008 | Nat Rev Cancer2008，8，5： | 1 |
| 20 | Three-dimensional imaging in fluorescence in confocal scanning microscopy显示文摘 | BRAKENHOFF G J van der VOORT H T M van SPRONSEN E A | 1989 | Journal of Microsopy1989，153，2： | 1 |
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