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| 1 | Hepatocyte-like cells from directed differentiation of mouse bone marrow cells in vitro显示文摘Aim: To design the effective directed differentiation medium to differentiate bone marrow cells into hepatocyte-like cells. Methods: Bone marrow cells were cultured in the directed differentiation media including fibroblast growth factor-4 (FGF-4) and oncostatin M (OSM). Hepatocyte-like cells from directed differentiation of bone marrow cells were identified through cell morphology, RNA expressions by reverse transcriptase-polymerase chain reaction (RT-PCR), protein expressions by Western blot, and hepatocellular synthesis and metabolism functions by albumin ELISA, Periodic acid-Shift staining and urea assay. Results: Some epithelial-like cells or polygonal cells appeared and increased in the course of the cell directed differentiation. Hepatocyte nucleur factor-3β(HNF-3β), albumin (ALB), cytokeratin 18 (CK18), transthyretin (TTR), glucose-6-phosphate (G-6-Pase), and tyrosine aminotransferase (TAT) mRNA were expressed in the course of the directed differentiation. The directed differentiated cells on d 21 expressed HNF-3β, ALB, and CK18 proteins. The directed differentiated cells produced albumin and synthesized urea in a time-dependent manner. They could also synthesize glycogen. Conclusion: Our differentiation media, including FGF-4 and OSM, are effective to differentiate bone marrow cells into hepatocyte-like cells, which could be used for hepatocyte resources for bioartificial liver or hepatocyte transplantation. | Xiao-leiSHI Yu-dongQIU QiangLI TingXIE Zhang-huaZHU Lei-leiCHEN LeiLI Yi-taoDING | 2005 | Acta Pharmacologica Sinica2005，26，4： | 8 |
| 2 | Abrupt temperature change and a warming hiatus from 1951 to 2014 in Inner Mongolia, China显示文摘An abrupt temperature change and a warming hiatus have strongly influenced the global climate.This study focused on these changes in Inner Mongolia, China. This study used the central clustering method, Mann-Kendall mutation test and other methods to explore the abrupt temperature change and warming hiatus in three different temperature zones of the study region based on average annual data series.Among the temperature metrics investigated, average minimum temperature(Tnav) shifted the earliest,followed by average temperature(Tnv) and average maximum temperature(Txav). The latest change was observed in summer(1990 s), whereas the earliest was observed in winter(1970 s). Before and after the abrupt temperature change, Tnav fluctuated considerably, whereas there was only a slight change in Txav.Before and after the abrupt temperature change, the winter temperature changed more dramatically than the summer temperature. Before the abrupt temperature change, Tnav in the central region(0.322°C/10 a)and west region(0.48°C/10 a) contributed the most to the increasing temperatures. After the abrupt temperature change, Tnav in winter in the central region(0.519°C/10 a) and in autumn in the west region(0.729°C/10 a) contributed the most to the temperature increases. Overall, in the years in which temperature shifts occurred early, a warming hiatus also appeared early. The three temperature metrics in spring(1991)in the east region were the first to exhibit a warming hiatus. In the east region, Txav displayed the lowest rate of increase(0.412°C/a) in the period after the abrupt temperature change and before the warming hiatus,and the highest rate of increase after the warming hiatus. | MA Long LI Hongyu LIU Tingxi LIANG Longteng | 2019 | Journal of Arid Land2019，11，2： | 3 |
| 3 | Landform classification using soil data and remote sensing in northern Ordos Plateau of China显示文摘地形分类通常仅仅用地志的高度被做。然而,实践显示在一样的高度的地点可以有显然不同的地形,取决于在那些地点下面的土壤的特征。这研究的目的到过:1 ) 开发基于高度和土壤特征的一条地形分类途径;并且 2 ) 使用这条途径在位于中国的北 Ordos 高原的一个分水岭以内决定地形。用从 200 个采样地点在 134 点收集的数据,这研究决定了那 D10 (土壤粒子的直径10%由重量更好)并且在 2010 获得的长期的平均土壤潮湿,能从遥感形象在合理精确性被估计,能被用来代表学习分水岭的土壤特征。另外,采样数据表明这个分水岭由地形的九个班组成,也就是活动的沙丘( MD ),活动半活动的沙丘( SMD ),滚动固定修理半的沙丘(讨论请求),完全沙的土地( FD ),草多的沙的土地( GS ),基岩( BR ),完全沙的基岩( FSB ),山谷农业土地( VA )和盐湖( SW )。一套逻辑回归方程用在 134 个采样地点收集并且验证了在留下使用数据的数据被导出 66 个地点。确认显示这些方程有中等分类精确性(Kappa 系数[^(K)]\hat K >43%) 。结果表明在学习分水岭的主导的班是 FD (36.3%), BR (27.0%),和 MD (23.5%)地形的另外的六种类型(即, SMD ,讨论请求, GS , FSB , VA ,并且 SW )在为13.2%的联合报道。进一步,在这研究决定的地形与一张地质上基于的分类地图介绍的班相比。比较显示地质上基于的分类不能在依赖于土壤特征的一个班以内识别多重地形。 | LUO Yanyun LIU Tingxi WANG Xixi DUAN Limin ZHANG Shengwei SHI Junxiao | 2012 | Journal of Geographical Sciences2012，22，4： | 3 |
| 4 | Cardiac Na^(+)-Ca^(2+) exchanger 1(ncx1h)is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish显示文摘Ca^(2+) signaling is critical for heart development;however,the precise roles and regulatory pathways of Ca^(2+) transport proteins in cardiogenesis remain largely unknown.Sodium-calcium exchanger 1(Ncx1)is responsible for Ca^(2+) efflux in cardiomyocytes.It is involved in cardiogenesis,while the mechanism is unclear.Here,using the forward genetic screening in zebrafish,we identified a novel mutation at a highly-conserved leucine residue in ncx1 gene(mutant^(LDD353)/ncx1h^(L154P))that led to smaller hearts with reduced heart rate and weak contraction.Mechanistically,the number of ventricular but not atrial cardiomyocytes was reduced in ncx1h^(L154P) zebrafish.These defects were mimicked by knockdown or knockout of ncx1h.Moreover,ncx1h^(L154P) had cytosolic and mitochondrial Ca^(2+) overloading and Ca^(2+) transient suppression in cardiomyocytes.Furthermore,ncx1h^(L154P) and ncx1h morphants downregulated cardiac transcription factors hand2 and gata4 in the cardiac regions,while overexpression of hand2 and gata4 partially rescued cardiac defects including the number of ventricular myocytes.These findings demonstrate an essential role of the novel 154th leucine residue in the maintenance of Ncx1 function in zebrafish,and reveal previous unrecognized critical roles of the 154th leucine residue and Ncx1 in the formation of ventricular cardiomyocytes by at least partially regulating the expression levels of gata4 and hand2. | Liming Chu Huimin Yin Lei Gao Li Gao Yu Xia Chiyuan Zhang Yi Chen Tingxi Liu Jijun Huang Kenneth R.Boheler Yong Zhou Huang-Tian Yang | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 5 | Influences of landform as a confounding variable on SOM-NDVI association in semiarid Ordos Plateau显示文摘Soil organic matter(SOM) plays an important role in maintaining vegetation cover and thus mitigating land erosion of fragile terrestrial ecosystems such as in the Northern Ordos Plateau of China(NOPC).However,little information is available on whether and how SOM varies spatially as an intrinsic characteristic of landform in NOPC.The objective of this study was to examine the spatial associations of SOM with landform and vegetation cover.The study was conducted in a 23,000-km2 area within NOPC because this area has landforms of mobile dunes(MD),flat dunes(FD),grassy sandy land(GSL),flat sandy bedrocks(FSB),and swamps and salt lakes(SW),which are typical landforms in semiarid ecosystems.SOM was determined using a standard laboratory analysis method for 5 cm topsoil samples collected at 72 locations across the study area.In addition,the 250 m Multitemporal Moderate Resolution Imaging Spectroradiometer(MODIS) imageries taken in the period from August 2006 to August 2010 were used to extract Normalized Difference Vegetation Index(NDVI) which in turn was used as the surrogate of vegetation cover.Classic and geostatistical methods were used to compare SOM concentration across different landforms.The results indicated that an area with a greater value for NDVI(i.e.better vegetation cover) tended to have a higher SOM concentration regardless of the landform types.However,the association between SOM and NDVI varied from one landform to another.The SW and GSL had a highest SOM concentration,while MD had a lowest concentration.For the study area as a whole and the FD,GSL,and MD,SOM was found to be the sole function of NDVI,whereas,for the FSB,SOM was influenced by several intrinsic variables,namely ground surface altitude,slope,and aspect,as well as NDVI.SOM for the SW landform was found to be a function of NDVI.Furthermore,SOM and NDVI exhibited a consistent spatial pattern of increasing from north to south and from west to east.The highest SOM concentration of 3.5% occurred along an east-westward belt,which is adjacent to water pathways,in the mid part of the study area. | YanYun LUO TingXi LIU XiXi WANG LiMin DUAN | 2012 | Journal of Arid Land2012，4，4： | 2 |
| 6 | Synthesis and water absorbency of poly(acrylic acid-co- acrylamide)显示文摘 | Li Tingxi Kong Na Gao Susu | 2011 | Advanced Materials Research2011，250，： | 1 |
| 7 | Organic Electrofluorescent Materials Using Pyridine-Containing Macrocyclic Compounds显示文摘Novel pyridine-containing macrocyclic compounds,such as 6,12,19,25-tetramethyl-7,11,20,24-dinitrilo-dibenzo [b,m]1,4,12,15-tetra-azacyclodoc osine(TMCD),were synthesized and used as electron transport layer in organic electroluminescent devices.Devices with a structure of glass/indium-tin oxide/arylamine derivative/ tris(quinolinolato)aluminum(Ⅲ)(Alq)/TMCD/LiF/Al exhibited green emission from the Alq layer with external quantum efficiency of 0.84% and luminous efficiency of 1.3 lm/W.The derivatives of TMCD were synthesized and characterized as well.These compounds were also found to be useful as the electron-transporting materials in organic electroluminescent devices. | Tingxi LI Long FU Wenwen YU Renhe HUANG | 2008 | Journal of Materials Science & Technology2008，24，5： | 1 |
| 8 | Simulated soil erosion from a semiarid typical steppe watershed using an integrated aeolian and fluvial prediction model显示文摘 | Xixi Wang Tingxi Liu Fengling Li Ruizhong Gao Xiaomin Yang Limin Duan Yanyun Luo Rui Li | 2014 | Hydrol Process2014，，2： | 1 |
| 9 | Synthesis and Water Absorbency of Poly(acrylic acid-co-acrylamide)显示文摘 | Li Tingxi Kong Na Gao Su Su Sui Peng Zhao Yu Hua Yuan Cheng Qian | 2011 | Advanced Materials Research2011，，250： | 1 |
| 10 | Missing interpolation model for wind power data based on the improved CEEMDAN method and generative adversarial interpolation network显示文摘Randomness and fluctuations in wind power output may cause changes in important parameters(e.g.,grid frequency and voltage),which in turn affect the stable operation of a power system.However,owing to external factors(such as weather),there are often various anomalies in wind power data,such as missing numerical values and unreasonable data.This significantly affects the accuracy of wind power generation predictions and operational decisions.Therefore,developing and applying reliable wind power interpolation methods is important for promoting the sustainable development of the wind power industry.In this study,the causes of abnormal data in wind power generation were first analyzed from a practical perspective.Second,an improved complete ensemble empirical mode decomposition with adaptive noise(ICEEMDAN)method with a generative adversarial interpolation network(GAIN)network was proposed to preprocess wind power generation and interpolate missing wind power generation sub-components.Finally,a complete wind power generation time series was reconstructed.Compared to traditional methods,the proposed ICEEMDAN-GAIN combination interpolation model has a higher interpolation accuracy and can effectively reduce the error impact caused by wind power generation sequence fluctuations. | Lingyun Zhao Zhuoyu Wang Tingxi Chen Shuang Lv Chuan Yuan Xiaodong Shen Youbo Liu | 2023 | Global Energy Interconnection2023，6，5： | 1 |
| 11 | Effects of maternal oral administration ofmonosodium glutamate at a late stage of pregnancy on developing mouse fetal brain显示文摘 | Yu Tingxi Zhao Yan Shi Wenchun | 1997 | Brain Res1997，747，： | 1 |
| 12 | Organic EL Device with Electron- Transporting Pyridine-Containing Marocyclic Compound 显示文摘 | Li Tingxi Junji Kido | 2002 | Ploymer Preprints2002，51，4： | 1 |
| 13 | 显示文摘 | Li Tingxi Lan H L Kido J | 2002 | Ploymer Preprints2002，51，： | 1 |
| 14 | Variations of alkaline phosphatase activity and P fractions in sediments of a shallow Chinese eutrophic lake (lake Taihu)显示文摘 | ZHANG Tingxi WANG Xiaorong JIN Xiangcan | 2007 | Environmental Pollution2007，150，2： | 1 |
| 15 | Potent protection of Danshensu (β-3, 4-dihydroxyphenyl-lactic acid) against excitotoxic effects of maternal intragastric administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain显示文摘Recent studies have demonstrated that ferulic acid [3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid] and sodium ferulate produce protective effects against glutamate-induced neurotoxicity in adult mice. Danshensu (β-3, 4-dihydroxyphenyl-lactic acid) has a similar molecular structure and pharmacological action to caffeic acid. This study aimed to validate the protection conferred by Danshensu against excitotoxic effects of maternal intragastric administration of monosodium glutamate at late stages of pregnancy in the developing mouse fetal brain. Behavioral tests, as well as histopathological and immunohistochemical examination of hippocampi were performed in filial mice. Results revealed that maternal intragastric administration of excessive monosodium glutamate (1.0, 2.0, 4.0 g/kg body weight) at a late stage of pregnancy resulted in a series of behavioral disorders (hyperactivity, lesions of learning and memory, and disturbance in cooperation of movement ability under high-altitude stress), histopathological impairment (neuronal edema, degeneration, necrosis, and hyperplasia) and molecular cellular biological changes (upregulated expression of N-methyl-D-aspartate receptor type 1 and neuropeptide Y in the hippocampal region of the brain of the filial mice from mothers treated with monosodium glutamate). Simultaneous administration of sodium Danshensu partially reversed the effects of monosodium glutamate on the above mentioned phenomena. These findings indicate that sodium Danshensu exhibits obvious protective effects on the excitotoxicity of monosodium glutamate. | Jingen Shen Lijian Yu Rundi Ma Yongping Zhang Xiaoyu Zhang Juanzhi Fang Tingxi Yu | 2010 | Neural Regeneration Research2010，5，20： | 0 |
| 16 | ORPOM model for optimum distribution of tree ring sampling based on the climate observation network显示文摘Tree ring dating plays an important role in obtaining past climate information.The fundamental study of obtaining tree ring samples in typical climate regions is particularly essential.The optimum distribution of tree ring sampling sites based on climate information from the Climate Observation Network(ORPOM model) is presented in this article.In this setup,the tree rings in a typical region are used for surface representation,by applying excellent correlation with the climate information as the main principle.Taking the Horqin Sandy Land in the cold and arid region of China as an example,the optimum distribution range of the tree ring sampling sites was obtained through the application of the ORPOM model,which is considered a reasonably practical scheme. | Long Ma TingXi Liu YanYun Luo HongLan Ji ShiQiang Li JunXiao Shi | 2010 | Research in Cold and Arid Regions2010，2，6： | 0 |
| 17 | Research progress on three different types of noncoding RNAs related to ionizing radiation显示文摘Non-coding RNAs(ncRNAs)have attracted wide attention in the field of ionizing radiation(IR).They have been found to be involved in cell development,proliferation,differentiation,and apoptosis in both clinical radiotherapy and radiation protection studies.Despite the production of an increasing number of relevant reports in recent years,the molecular mechanisms involved are yet to be clearly understood.In the last few years,ncRNAs have received a lot of research attention,especially microRNAs,long noncoding RNAs,and circular RNAs,which have a well-known association with the development of human disease and are closely related to the biological phenotypic changes caused by IR.With recent developments of research methods,these ncRNAs might play a significant regulatory role in future radiation protection and radiotherapy.This review will summarize the research progress of various types of ncRNAs as biomarkers of IR and potential new targets for radiotherapy,aiming to provide references for future research and the formulation of new strategies. | Jin Gao Xumin Zong Na Chen Tingxi Lan Wentao Yu Huiqiang Long Fengmei Cui Yu Tu | 2021 | Radiation Medicine and Protection2021，2，2： | 0 |
| 18 | Transformation among precipitation,surface water,groundwater,and mine water in the Hailiutu River Basin under mining activity显示文摘Coal mining has changed the hydrogeological conditions of river basins,and studying how the relationship among different types of water body has changed under the influence of coal mining is of great significance for understanding the regional hydrological cycle.We analyzed the temporal and spatial distribution of hydrochemical properties and environmental isotopes in the Hailiutu River Basin(HRB),China with a mixed model.The results showed that:(1)human activity(e.g.,coal mining and agricultural production)causes considerable changes in the hydrochemical properties of surface water in and around the mining areas,and leads to significant increases in the concentrations of Na^(+)and SO_(4)^(2-);(2)precipitation is the main source of water vapour in the HRB.The transformation between surface water and groundwater in the natural watershed is mainly affected by precipitation;and(3)in the mining areas,the average contribution rates of precipitation to the recharge of surface water and groundwater increased by 2.6%-7.9%and 2.7%-9.9%,respectively.Groundwater in the Salawusu Formation constitutes up to 61.3%-72.4%of mine water.Overall,this study is beneficial for quantifying the effects of coal mining on local hydrological cycles.The research results can provide a reference for local water resources management and ecological environment improvement. | LI Qian MA Long LIU Tingxi | 2022 | Journal of Arid Land2022，14，6： | 0 |
| 19 | Boosting efficiency and stability of 2D alternating cation perovskite solar cells via rational surface-modification: Marked passivation efficacy of anion显示文摘Two-dimensional(2D) alternating cation(ACI) perovskite surface defects,especially dominant iodine vacancies(V_Ⅰ) and undercoordinated Pb^(2+),limit the performance of perovskite solar cells(PVSCs).To address the issue,1-butyl-3-methylimidazolium trifluoro-methane-sulfonate(BMIMOTF) and its iodide counterpart(BMIMI) are utilized to modify the perovskite surface respectively.We find that BMIMI can change the perovskite surface,whereas BMIMOTF shows a nondestructive and more effective defect passivation,giving significantly reduced defect density and suppressed charge-carrier nonradiative recombination.This mainly attributes to the marked passivation efficacy of OTF-anion on V_Ⅰ and undercoordinated Pb^(2+),rather than BMIMI^(+) cation.Benefiting from the rational surface-modification of BMMIMOTF,the films exhibit an optimized energy level alignment,enhanced hydrophobicity and suppressed ion migration.Consequently,the BMIMOTF-modified devices achieve an impressive efficiency of 21.38% with a record open-circuit voltage of 1.195 V,which is among the best efficiencies reported for 2D PVSCs,and display greatly enhanced humidity and thermal stability. | Hualin Zheng Xuefeng Peng Tingxi Chen Ting Zhang Shihao Yuan Lei Wang Feng Qian Jiang Huang Xiaodong Liu Zhi David Chen Yanning Zhang Shibin Li | 2023 | Journal of Energy Chemistry2023，，9： | 0 |
| 20 | Effect of climatic change on surface environments in the typical region of Horqin Sandy Land显示文摘The town of Agura,a typical region in Horqin Sandy Land,was selected as the study area in this paper.Using 12 remote sensing images and climatic data from the past 20 years,the effects of climate change on surface environments were analyzed.The impact indices of climatic factors,along with their corresponding ranks,were used to characterize the responses of different types of surface environments to climate change.Results show that in the past 20 years,the surface environments of the study area have been deteriorating.Furthermore,there is a positive relationship between the changes in surface environments and those in climatic factors.Various climatic factors influence surface environments in different ways and at different levels.The most sensitive factor is relative humidity,followed by precipitation and evaporation.Overall,moisture is the key factor that affects the changes in surface environments of arid and semi-arid areas. | Long Ma TingXi Liu HongLan Ji YanYun Luo LiMin Duan | 2010 | Research in Cold and Arid Regions2010，2，2： | 0 |
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