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| 1 | Heavy metal pollution in intertidal sediments from Quanzhou Bay, China显示文摘The concentrations of eight heavy metals (Cu, Zn, Pb, Cd, Cr, Ni, Hg, and As) in the intertidal surface sediments from Quanzhou Bay were determined to evaluate their levels and spatial distribution due to urbanization and economic development of Quanzhou region, southeast China. The ranges of the measured concentrations in the sediments are as follows: 24.8–119.7 mg/kg for Cu, 105.5–241.9 mg/kg for Zn, 34.3–100.9 mg/kg for Pb, 0.28–0.89 mg/kg for Cd, 51.1–121.7 mg/kg for Cr, 16.1–45.7 mg/kg for Ni, 0.17–0.74 mg/kg for Hg, and 17.7–30.2 mg/kg for As. The overall average concentrations of above metals exceed the primary standard criteria but meet the secondary standard criteria of the Chinese National Standard of Marine Sediment Quality. Several contents of Cu and Hg exceed the secondary standard criteria at some stations. The results of geoaccumulation index (Igeo) show that Cd causes strong pollution in most of the study area. There are no significant correlations among most of these heavy metals, indicating they have different anthropogenic and natural sources. Some locations present severe pollution by heavy metals depending on the sources, of which sewage outlets, aquatic breeding, and commercial ports are the main sources of contaminants to the area. | YU Ruilian YUAN Xing ZHAO Yuanhui HU Gongren TU Xianglin | 2008 | Journal of Environmental Sciences2008，20，6： | 73 |
| 2 | 福建省社区产后访视质量调查研究显示文摘目的:研究社区产后访视服务现状,提高社区护理质量,促进母婴健康.方法:定量与定性研究相结合,定量研究随机抽取福州市5区内产后42 d左右的产妇776例问卷调查,定性研究采用专题小组讨论和半结构性访谈.产妇12人参加专题讨论,半结构性访谈9人.结果:产后访视率为62.9%,按3~4次标准进行的仅4.3%~48.2%.社区产后访视内容中,询问母子一般情况达98.4%;对产妇及新生儿体检的内容欠缺多;进行母乳喂养指导为94.7%;认为对产妇心理情绪状况'关心与非常关心'的占28.7%,对预防产后抑郁症的保健建议率占9.9%;对社区产后访视满意率不高为33.6%.结论:与产后访视的次数和内容的标准对照,实际操作中的偏差是由于缺乏规范化的管理,因此今后既要加快产后访视人员刘产褥期护理与保健知识的更新,拓展提供保健知识的内容,又要在现有社区产后访视过程中,加强规范化管理,区级妇幼保健机构应对辖区内的社区产妇的产后访视工作实行面对面的质量评估问卷,达到规范化管理的目的,并采取针对性措施提高产后访视中的护理与保健质量. | 陈起燕 陈烈平 张荣莲 叶宝凤 翁云钦 卓秀云 Yu liana Da tu Bua | 2005 | 中国妇幼保健2005，20，5： | 33 |
| 3 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 4 | Genome-Wide Association Studies of Image Traits Reveal Genetic Architecture of Drought Resistance in Rice显示文摘理解植物怎么对干旱作出回应能有益于繁殖的干旱抵抗(医生) 。用一台非破坏性的 phenotyping 设备,为 507 米饭就职的 51 个基于图象的特点(i 特点) 被提取。这些 i 特点能被用来监视干旱回答 ? 并且高评估医生可遗传性和这些特点的大变化在自然人口在干旱应力下面被观察。染色体宽的协会研究(GWAS )?i 特点和传统的医生特点识别了 470 协会 loci,某包含知道医生相关的基因。这 470 loci, 443 loci (94%) 用 i 特点被识别, 437 loci (93%) 与以前报导的医生相关的量的特点 loci,和 313 loci (66.6%)co 局部性被 GWAS reproducibly 在不同的年里识别。协会网络,基于 GWAS 建立了结果,揭示中心 i 特点和中心 loci。这表明把的可行性和必要性复杂医生特点进可继承、简单的 i 特点。作为原则的证明,我们说明了这条综合途径的力量以前识别 unreported 医生相关的基因。OsPP15 与中心 i 特点被联系,并且它在医生的角色被基因转变实验证实。而且, i 特点能被用于医生连接分析,并且 69 个 i 特点地点协会被 recombinant 的 GWAS 和连接分析识别生来的线人口。最后,我们证实了 i 特点的关联在这个领域里搀。我们的学习为医生为原因的基因的基因解剖和发现提供一条有希望的新奇途径。 | Zilong Guo Wanneng Yang Yu Chang Xiaosong Ma Haifu Tu Fang Xiong Ni Jiang Hui Feng Chenglong Huang Peng Yang Hu Zhao Guoxing Chen Hongyan Liu Lijun Luo Honghong Hu Qian Liu Lizhong Xiong | 2018 | Molecular Plant2018，11，6： | 21 |
| 5 | Assessment of hepatic functional reserve by cirrhosis grading and liver volume measurement using CT显示文摘AIM: To explore a method for quantitative assessment of hepatic functional reserve by combining computed tomography (CT) volumetry with CT grading of liver cirrhosis before liver resection in patients with hepatocellular carcinoma. METHODS: CT images of 55 patients undergoing liver resection were studied prospectively. The degree of liver cirrhosis was referred as 'CT grade' and the percentage of remnant liver volume (PRLV) [PRLV = predicted RLV/predicted total liver volume (PTLV) × 100%; PTLV (mL) = 121.75 + 16.49 × body mass (kg)] were calculated by adding slice by slice of CT liver images. The postoperative RLV, pathologic stages of liver fibrosis in non-tumor area and survival time in these cases were analyzed. RESULTS: There was a significant difference in survival time between the group with PRLV ≤ 50% and the group with PRLV > 50% (χ2 = 4.988, P = 0.026), and between the group with CT grade 0/1 and the group with CT grade 2/3 (χ2 = 5.429, P = 0.026). With combination of the both parameters, an oblique line was identified according to the distribution of 32 survivors versus 23 deceased subjects. The mortality rate above the line was 7.1% (1/14), and that below the line was 53.7% (22/41), indicating a significant difference between the two rates (χ2 = 9.281, P = 0.002, P < 0.05). CONCLUSION: PRLV and CT grades are significantly correlated with hepatic functional reserve. The predicted line using these two parameters is useful in candidatesundergoing liver resection for judging hepatic functional reserve. | Rong Tu Li-Ping Xia An-Le Yu Ling Wu | 2007 | World Journal of Gastroenterology2007，13，29： | 21 |
| 6 | A modified single-armed technique for microsurgical vasoepididymostomy显示文摘这研究是与 epididymal 在病人为 microsurgical vasoepididymostomy (VE ) 评估一种修改武装单人赛的缝术技术的有效性妨碍的精子缺乏。从 2011 年 9 月到 2011 年 12 月, microsurgical 二缝术的纵的摄取 VE 与 epididymal 在 17 个人用我们的修改武装单人赛的缝术技术被执行在我们的医院的妨碍的精子缺乏。二个这些病人在以前的没有通过的 VE 以后经历了重复 VE,并且因为左腹的管 deferens 的吸藏,一个病人经历了单方的 VE。在在 3 月 postoperation 的精液样品的精子的存在被用作这研究的初步的端点。每个病人在 3 月的时间点提供了至少一件精液样品,并且明显被精子的再现估计(>在精液的 10 4 ml −1) 。修改技术的吝啬的起作用的时间是 219 min。明显在 10 个人被注意(58.8 %) ,包括经历了重复 VE 的一个病人。经历了单方的吻合的病人没在他的精液手术后地表明精子。精子 granulomas 没在这个队被检测。这研究的结果表明那我们为 microsurgical 的修改技术纵的摄取 VE 有效。我们相信是一种实际选择可以减少操作时间并且排除缝术十字路口。 | Liang Zhao Chun-Hua Deng Xiang-Zhou Sun Yu Chen Wen-Wei Wang Liang-Yun Zhao Ling-You Zeng Xiang-An Tu | 2013 | Asian Journal of Andrology2013，15，1： | 19 |
| 7 | Electroacupuncture alters pain-related behaviors and expression of spinal prostaglandin E_2 in a rat model of neuropathic pain显示文摘OBJECTIVE: To investigate the role of spinal prostaglandin E_2(PGE_2) in electroacupuncture(EA) analgesia and assess the theoretical basis for selection of acupoints in the treatment of neuropathic pain.METHODS: A rat model of neuropathic pain was established. Rats were randomly divided into normal,model, sham, EA 1, EA 2, and EA 3 groups. In EA 1group, the rats were needled at bilateral L5 Jiaji(EX-B2), Dachangshu(BL 25), Weizhong(BL 40) and Kunlun(BL 60). In EA 2 group, the rats were needled at bilateral Weizhong(BL 40) and Kunlun(BL60). In EA 3 group, the rats were needled at bilateral L5 Jiaji(EX-B2) and Dachangshu(BL 25). EA stimulation was administered once daily over 7 days. Motor function and thermal withdrawal latencies were evaluated at 1 day preoperatively and at 3, 5, and 7 days postoperatively. After 7 days of intervention,enzyme-linked immunosorbnent assay(ELISA) was used to quantify the expression of the spinal PGE_2.RESULTS: Rats in the model group exhibited evident hyperalgesia in responses to thermal withdrawal latencies compared with those in the control group(P < 0.01), and EA reversed thermal withdrawal latencies(P < 0.01). The expression level of the spinal PGE_2 was significantly higher in the model group than that in the control group and was reversed by EA(P < 0.01; P < 0.05).CONCLUSION: The effect of EA on neuropathic pain might alleviate the hyperalgesia state by an inhibition of local prostaglandin E_2 secretion. | Jiang Huili Yu Xue Ren Xiujun Tu Ya | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 19 |
| 8 | Diffusion tensor imaging assesses white matter injury in neonates with hypoxic-ischemic encephalopathy显示文摘With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term infants without brain injury and twenty-two full-term neonates with hypoxic-ischemic encephalopathy(14 moderate cases and 8 severe cases) underwent diffusion tensor imaging to assess its feasibility in evaluating white matter damage in this condition. Results demonstrated that fractional anisotropy, voxel volume, and number of fiber bundles were different in some brain areas between infants with brain injury and those without brain injury. The correlation between fractional anisotropy values and neonatal behavioral neurological assessment scores was closest in the posterior limbs of the internal capsule. We conclude that diffusion tensor imaging can quantify white matter injury in neonates with hypoxic-ischemic encephalopathy. | Hong-xin Li Xing Feng Qian Wang Xuan Dong Min Yu Wen-juan Tu | 2017 | Neural Regeneration Research2017，12，4： | 19 |
| 9 | Intercropping with Solanum nigrum and Solanum photeinocarpum from Two Ecoclimatic Regions Promotes Growth and Reduces Cadmium Uptake of Eggplant Seedlings显示文摘Soil contamination by heavy metals is a serious environmental problem worldwide, and reduction of heavy metal accumulation in vegetables grown on contaminated land is a matter of urgency. A pot experiment was conducted to study the effects of intercropping with the Cd hyperaccumulators Solanum nigrum and Solanum photeinocarpum from two ecoclimatic regions, Ya'an and Chengdu,Sichuan Province, China, on the growth and cadmium(Cd) uptake of eggplant(Solanum melongena L.). The biomass, photosynthetic pigment contents, and activities of antioxidant enzymes of eggplant were enhanced by intercropping. The biomass of eggplant was the highest after intercropping with S. photeinocarpum from Ya'an, but did not differ significantly from that after intercropping with S. nigrum from Chengdu. The shoot Cd content of eggplant was significantly reduced by intercropping with the hyperaccumulators,which ranked as follows: S. nigrum from Chengdu > S. nigrum from Ya'an > S. photeinocarpum from Chengdu > S. photeinocarpum from Ya'an, with the decreases being 19.60%, 14.36%, 9.66%, and 6.42%, respectively, as compared with the control. The lowest shoot Cd content and translocation factor of eggplant were attained after intercropping with S. nigrum from Chengdu. Therefore, it was feasible to intercrop eggplant with S. nigrum and S. photeinocarpum on Cd-contaminated soil. | TANG Yi HE Juan YU Xuena XIE Yongdong LIN Lijin SUN Guochao LI Huanxiu LIAO Mingan LIANG Dong XIA Hui WANG Xun ZHANG Jing LIU Zejing TU Lihua LIU Li | 2017 | Pedosphere2017，27，3： | 17 |
| 10 | Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway显示文摘The saponin ginsenoside Rk1 is a major compound isolated from ginseng.Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism.However,the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified.We investigated whether ginsenoside Rk1 could suppress the inflammatory response in lipopolysaccharide-stimulated RAW264.7 macrophages and to explore its mechanism of the action.RAW264.7 cells were treated with LPS(1 μg×mL^(–1))in the absence or the presence of Ginsenoside Rk1(10,20,and 40 μmol×L^(–1)).Then the inflammatory factors were tested with Griess reagents,ELISA,and RT-PCR.The proteins were analyzed by Western blotting.Ginsenoside Rk1 inhibited lipopolysaccharide-induced expression of nitric oxide(NO),interleukin(IL)-6,IL-1β,tumor necrosis factor(TNF)-α,and monocyte chemotactic protein(MCP)-1.Ginsenoside Rk1 inhibited the lipopolysaccharide-stimulated phosphorylation of NF-κB and janus kinase(Jak)2 and signal transducer and activator of transcription(Stat)3 at Ser727 and Tyr705.These data suggested that ginsenoside Rk1 could inhibit expression of inflammatory mediators and suppress inflammation further by blocking activation of NF-κB and the Jak2/Stat3 pathway in LPS-stimulated RAW264.7 cells. | YU Qian ZENG Ke-Wu MA Xiao-Li JIANG Yong TU Peng-Fei WANG Xue-Mei | 2017 | Chinese Journal of Natural Medicines2017，15，10： | 17 |
| 11 | Effects of Honghua preserved amniotic membrane on scar healing in experimental glaucoma surgery显示文摘AIM:To investigate the efficacy and safety of Honghua preserved amniotic membrane(AM)for preventing scar formation of the filtering bleb in a rabbit model of glaucoma trabeculectomy surgery.METHODS:Totally 36 rabbits(36 eyes)were randomly divided into 3 groups:the experimental group(ocular trabeculectomy in combination with Honghua preserved AM transplantation),the control group(ocular trabeculectomy surgery in combination with AM implantation),and the blank group(single trabeculectomy).Clinical observations[including intraocular pressure(IOP),filtering blebs and complications],MassonTrichrome staining,real-time quantitative reverse transcription-polymerase chain reaction(real-time PCR),Western blot were performed on different time points(D1,D7,D14,D21 and D56)after the surgery.RESULTS:After operated for 14d,there were statistically significant differences in the filtering blebs compared to the situation before operation(P<0.05),whereas no statistically difference on that among three groups(P>0.05).After 21d,the IOP of experimental group was lowest(P<0.05).There was significant difference between control group and blank group(P<0.05).On postoperative D14,the mean number of fibroblasts in the experimental group was significantlylower(40.6±10.2)compared to those in the control group(54.4±10.8)and blank group(68.2±11.6)(P<0.05,respectively).The mean numbers of the macrophage in the experimental and control groups were respcitively significantly lower versus the blank group(P<0.05,P<0.05,respectively).Compared to that in blank group,the level of transforming growth factor-β(TGF-β1)expression in sclera and conjunctival areas was reduced in the experimental and control groups on protein and mRNA level(P<0.05),but not significant difference between these two groups(P>0.05).CONCLUSION:The trabeculectory surgery with Honghua preserved AM can control IOP,sustain the functional filtration bleb,inhibit the proliferation of fibroblasts and open the filtrating pathway on the rabbit glaucoma models. | Yi Shao Yao Yu Qiu-Ping Liu Jing-Ming Li Fei Dong Xin Huang Chong-Gang Pei Ping Tu Hen-Hui Li Gui-Ping Gao | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 16 |
| 12 | Environmental risks for application of iron and steel slags in soils in China: A review显示文摘Iron and steel slags are smelting wastes, mainly including blast furnace slag(BFS) and steel slag(SS) produced in the iron and steel industry. Utilization of iron and steel slags as resources for solving the problem of slag disposals has attracted much attention with increasing iron and steel smelting slags in China. Because the iron and steel slags contain calcium(Ca), magnesium(Mg), phosphorus(P), and silicon(Si), some have tried to use them as Si-and P-fertilizers, for producing Ca-Mg-P fertilizers, or as soil amendments in agriculture. However, in the iron metallurgical process, several pollutants in iron ores can inevitably transfer into iron and steel slags, resulting in the enrichment of pollutants both in BFS(mainly nickel(Ni), copper(Cu), mercury, zinc(Zn),cadmium(Cd), chromium(Cr), arsenic, lead, selenium, fluorine(F), and chlorine(Cl)) and in SS(mainly Ni, Cr, Cd, Zn, Cu, F, and Cl), in which some of pollutants(especially Cr, Ni, F, and Cl) exceed the limits of environmental quality standards for soils and groundwater. The elements of manganese, barium,and vanadium in iron and steel slags are higher than the background values of soil environment. In order to ensure soil health, food safety, and environmental quality, it is suggested that those industrial solid wastes, such as iron and steel slags, without any pretreatment for reducing harmful pollutants and with environmental safety risk, should not be allowed to use for soil remediation or conditioning directly in farmlands by solid waste disposal methods, to prevent pollutants from entering food chain and harming human health. | Xiaobin WANG Xiuying LI Xiang YAN Cheng TU Zhaoguo YU | 2021 | Pedosphere2021，31，1： | 14 |
| 13 | Au-decorated porous structure graphene with enhanced sensing performance for low-concentration NO2 detection显示文摘A recent progress in new emerging two-dimensional(2 D)materials has provided promising opportunity for gas sensing in ultra-low detectable concentration.In this work,we have demonstrated a flexible NO2 gas sensor with porous structure graphene on polyethylene terephthalate substrates operating at room temperature.The gas sensor exhibited good performance with response of 1.2%and a fast response time within 30 s after exposure to50×10^-9 NO2 gas.As porous structure of graphene increased the surface area,the sensor showed high sensitivity of ppb level for NO2 detection.Au nanoparticles were decorated on the surface of the porous structure graphene skeleton,resulting in an incensement of response compared with pristine graphene.Au nanoparticles-decorated graphene exhibits not only better sensitivity(1.5-1.6 times larger than pristine graphene)for NO2 gas detection,but also fast response.The sensor was found to be robust and sensitive under the cycling bending test,which could also be ascribed to the merits of graphene.This porous structure graphene-based gas sensor is expected to enable a simple and inexpensive flexible gas sensing platform. | Yan-Yan Fan Hai-Ling Tu Yu Pang Feng Wei Hong-Bin Zhao Yi Yang Tian-Ling Ren | 2020 | Rare Metals2020，39，6： | 13 |
| 14 | Pre-desilication and digestion of gibbsitic bauxite with lime in sodium aluminate liquor显示文摘The effect of lime on the pre-desilication and digestion of gibbsitic bauxite in synthetic sodium aluminate liquor at different temperatures was investigated. The bauxite is comprised of gibbsite, aluminogoethite, hematite, kaolin, quartz, and minor boehmite. Lime increases the desilication efficiency of the bauxite during the pre-desilication process by promoting the conversion of sodalite and cancrinite to hydrogarnet. Desilication reactions during the digestion process promoted by lime result in the loss of Al2O3 entering the red mud, but the amount of aluminogoethite-to-hematite conversion promoted by lime leads to the increase of aluminogoethitic Al2O3 entering the digested liquor. The alumina digestion rate at 245°C is higher than that at 145°C due to the more pronounced conversion of aluminogoethite to hematite. The soda consumption during the digestion process decreases due to lime addition, especially at higher temperatures. | Xiao-lin Pan Hai-yan Yu Kai-wei Dong Gan-feng Tu Shi-wen Bi | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，11： | 12 |
| 15 | Associations of Gonadotropin-Releasing Hormone Receptor (GnRHR) and Neuropeptide Y(NPY) Genes’Polymorphisms with Egg-Laying Traits in Wenchang Chicken显示文摘Single nucleotide polymorphisms(SNP)of chicken gonadotropin-releasing hormone receptor(GnRHR)and neuropeptide Y(NPY)were selected to identify the genotypes of Wenchang(Chinese indigenous breed)chicken with restricton fragment length polymorphisms.The associations of the SNPs with the total egg production(NE),average days of continual laying(ADCL),and number of double-yolked eggs(DYE)traits were analyzed.The frequency of restriction enzyme A/a alleles in the population was for GnRHR 0.69(Bpu1102ⅠA)and 0.31(Bpu1102Ⅰa)and for NPY 0.46(Dra ⅠB)and 0.54(DraⅠb).Trait data from a total of 120 hens,which were purebredintroduced from Hainan Province,China from one generation were recorded.Two significant effects of genes'marker were found:for GnRHR and number of eggs (dominant;t=2.67,df=116)and NPY and number of eggs(additive;t=1.97,df=116).The current research supports the effects of GnRHR and NPY genes on egg-laying traits of chickens. | WU Xu LI Hui-fang YAN Mei-jiao TANG Qing-ping CHEN Kuan-wei WANG Jin-yu GAO Yu- shi TU Yun-jie YU Ya-bo ZHU Wen-qi | 2007 | Agricultural Sciences in China2007，6，4： | 11 |
| 16 | A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis显示文摘Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis.Methods:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 weeks.The primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week 12.Results:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P<0.05)and placebo(13.9%,P<0.05)groups.The proportion of patients achieving an sPGA score 0 or 1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,P<0.05).In the long-term follow-up study,50.8%of patients experienced recurrence.After retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week 52.Adverse events included application site irritation,follicular papules,and contact dermatitis.No systemic adverse reactions were reported.Conclusion:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis. | Lin Cai Gen-Hui Chen Qian-Jin Lu Min Zheng Yu-Zhen Li Jin Chen Jie Zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu Li Sheng-Xiang Xiao Qiu-Ning Sun Jin-Hua Xu Xing-Hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-Zhong Liu Ya-Ting Tu Ruo-Yu Li Bao-Xi Wang Dan-Qi Deng Qing-Shan Zheng Hong-Xia Liu Jian-Zhong Zhang | 2020 | Chinese Medical Journal2020，，24： | 11 |
| 17 | Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE-/- mice possibly via activated STAT3-mediated upregulation of tristetraprolin显示文摘 | Kai YIN Shi-lin TANG Xiao-hua YU Guang-hui TU Rong-fang HE Jin-feng LI Di XIE Qing-jun GUI Yu-chang FU Zhi-sheng JIANG Jian TU Chao-ke TANG | 2013 | Acta Pharmacologica Sinica2013，34，6： | 11 |
| 18 | Huaiqihuang Granules(槐杞黄颗粒)Reduce Proteinuria by Enhancing Nephrin Expression and Regulating Necrosis Factor κB Signaling Pathway in Adriamycin-Induced Nephropathy显示文摘Objective: To investigate the effects of Huaiqihuang Granules(槐杞黄颗粒, HQH), a mixture of Chinese herbs including Trametes robiniophila Murr, Fructus Lycii and Polygonatum sibiricum, on adriamycininduced nephropathy(ADRN) in rats and its underlying mechanisms. Methods: Rats with ADRN were divided into four groups: the sham group, the model group(distilled water), the low-dose HQH-treated(2 g/kg) group, and the high-dose HQH-treated(4 g/kg) group. Body weight and 24-h urinary protein(Upro) were checked every week. After 5-week intervention, at the end of the study, the rats were sacrificed and blood samples were collected for examination of biochemical parameters, including glomerular morphological makers, podocyte shape, cellular apoptosis, expressions of nephrin, inflammatory and apoptosis markers. Results: HQH ameliorated the rat's general status, proteinuria, renal morphological appearance and glomerulosclerosis. The decreased expression of nephrin in ADRN rats was increased by HQH, as well as the impaired podocyte foot process fusion. Cytosolic levels of p65 and inhibitor of nuclear factor κBα(IκBα) were decreased in ADRN rats, and recovered by the treatment of HQH. Consistently, the induced expression of tumor necrosis factor α(TNF-α), phosphorylated nuclear factor κB p65(p-NFκB p65) and IκBα in ADRN were markedly suppressed by HQH. In addition, induction of Bax, cleaved caspase-3 and cytochrome C in ADRN rats were suppressed by HQH, indicating the amelioration of apoptosis. Conclusion: HQH could ameliorate renal impairments in ADRN rats by increasing nephrin expression, inhibiting NF-κB signaling pathway via the down-regulation of p-NF-κB p65 and p-IκBα, and suppression of glomerular and tubular apoptosis. | LIU Hong SUN Wei GU Liu-bao TU Yue YU Bing-yin HU Hao | 2017 | Chinese Journal of Integrative Medicine2017，23，4： | 10 |
| 19 | Prognostic factors of trans-ethmosphenoid optic canal decompression for indirect traumatic optic neuropathy显示文摘● AIM: To investigate a possible correlation between visual acuity(VA) prognosis and the presence at baseline of various orbital and ocular signs in patients affected by indirect traumatic optic neuropathy(ITON).● METHODS: From July 1 st, 2012 to July 1 st, 2015, 224 adults diagnosed with ITON who underwent endoscopic transethmosphenoid optic canal decompression(ETOCD) were reviewed. Visual outcome before and after treatment were taken into comparison.● RESULTS: Accompanied older in age, longer time to medical treatment and existence of optic canal fracture(OCF) were the independent predictors for poor postoperative VA and lower improvement degree of visual acuity(IDVA), while worse preoperative VA was predictive factor for poor postoperative VA only. Mean value of IDVA in patients with OCF was 0.19±0.30. Mean value of IDVA in patients without OCF was 0.29±0.35. IDVA in cases without OCF was significant higher than those with OCF(t=2.272, P<0.05).● CONCLUSION: Patients suffered from ITON without OCF before ETOCD have better surgical outcome than those with OCF. Older in age, longer time to medical treatment and existence of OCF are independent factors for poor VA prognosis and lower IDVA. Preoperative VA is independent factor for VA prognosis only. | Ying-Jie Ma Bo Yu Yun-Hai Tu Bang-Xun Mao Xin-Yi Yu Wen-Can Wu | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 10 |
| 20 | Framework on robotic percussive riveting for aircraft assembly automation显示文摘Presented in this paper is a framework for the implementation of a robotic percussive riveting system, a new robot application for aircraft assembly. It is shown here that a successful robot application to the automation of a process requires in-depth research of the process and the interaction with the robot. For this purpose, a process planning-driven approach is proposed to guide a robot application research. A typical process planning will involve a list of key considerations including: process sequence, process parameters, process tooling, and process control. Through this list, a number of key research issues are identified for robotic percussive riveting, such as rivet pattern planning, rivet time determination, rivet tooling design and rivet insertion control. The detailed research on these issues has effectively created know-how for the successful implementation of our robotic percussive riveting system. | Feng-Feng Xi Lin Yu Xiao-Wei Tu | 2013 | Advances in Manufacturing2013，1，2： | 10 |
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