|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | 16S rRNA targeted sandwich hybridization method for direct quantification of mycobacteria in soils 显示文摘 | Timo N Jaakko P Irina T | 2004 | Journal of Microbiological Methods2004，67，： | 1 |
| 3 | The role of automated urine particle flow cytometry in clinical practice显示文摘 | Joris R Delanghe Timo T Kouri Andreas R Huber Kurt Hannemann-Pohl Walter G Guder Andreas Lun Pranav Sinha Gudrun Stamminger Lothar Beier | 2000 | Clinica Chimica Acta2000，，1： | 1 |
| 4 | Dynamic Mod- el of an Electromagnetic Massive Core Brake Actuator 显示文摘 | Timo T Vekara Jarl-Thure Eriksson Juha T Tanttu | 1996 | 1EEE Transactions on Magnetics1996，32，3： | 1 |
| 5 | Clonal differences in growth and phenolics of willows exposed to elevated ultraviolet-B radiation显示文摘 | RIITTA T TIMO V PEDRO J A et ai | 2003 | Basic Appl Ecol2003，4，3： | 1 |
| 6 | 5-HT3 Receptor antagonists in the prophylaxis of acute vomiting induced by moderately emetogenic chemotherapy a randomised study显示文摘 | Timo J Vesa V | 1993 | Eur J Cancer1993，29，12： | 1 |
| 7 | Fibrosis and stenosis of the long penetrating cerebral arteries:the cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy显示文摘 | Qing M Timo P Susanna T | 2004 | Brain Pathology2004，14，4： | 1 |
| 8 | Unawareness in environmental protection ' the case of light pollution from traffic 显示文摘 | Jari L Petri T Timo A | 2012 | Land Use Policy2012，29，3： | 1 |
| 9 | Valproic acid combined with 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 in the treatment of patients with myelodysplastic syndromes 显示文摘 | Timo S Timo T Eeva J | | Haematologica0，92，8： | 1 |
| 10 | Cross-cultural differences in driving behaviors:a comparison of six countries显示文摘 | Türkerzkan Timo Lajunen T Joannes E l | 2006 | Transportation Research Part F:Psychology and Behavior2006，9，3： | 1 |
| 11 | Capital Investment Timing and Convertible Debt Financing显示文摘 | TIMO KORKEAMAKI WILLIAM T MOORE | 2004 | International Review of Economics & Finance2004，13，1： | 1 |
| 12 | Fibrosis and stenosis of the long penetrating cerebral arteries: the cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy显示文摘 | Qing M Timo P Susanna T | 2004 | Brain Pathology2004，14，： | 1 |
| 13 | Exhaust Particulate Emissions of a Mustard Seed Oil Driven Tractor Engine 显示文摘 | SEPPO A Niemi TIMO T Murtonen MIKA J Lauren | 2002 | SAE Paper 0208662002，，： | 1 |
| 14 | Force and torque computations with hybrid methods显示文摘 | Koski A Kimmo F Timo T | 1999 | IEEE Transactions on Magnetics1999，35，3： | 1 |
| 15 | Vascular cognitive impairment显示文摘 | John T O’Brien Timo Erkinjuntti Barry Reisberg Gustavo Roman Tohru Sawada Leonardo Pantoni John V Bowler Clive Ballard Charles DeCarli Philip B Gorelick Kenneth Rockwood Alistair Burns Serge Gauthier Steven T DeKosky | 2003 | Lancet Neurology2003，，2： | 1 |
| 16 | Compact damping models for laterally moving microstructures with gas-rarefaction effects 显示文摘 | Timo V Marek T | 2001 | IEEE Journal of MEMS2001，10，2： | 1 |
| 17 | Favourable pregnancy results with insemination of in vitro matured oocytes from unstimulated patients 显示文摘 | Viveca SA Sirpa M Timo T | 2005 | Hum Reprod2005，20，6： | 1 |
| 18 | Role of microbes in controlling the speciation of arsenic and production of arsines in contaminated soils显示文摘 | Riina T Mari P K Timo K | 2002 | The Science of the Total Environment2002，285，： | 1 |
| 19 | Vascular cognitive impairment显示文摘 | John T O'Brien Timo Erkinjuntti Barry Reisbery | 2003 | Lancet Neurol2003，2，2： | 1 |
| 20 | Hydrophobic do- mains affect the collagen-binding specificity and surface polymeri- zation as well as the virulence potential of the YadA protein of Yersiniaenterocolitica显示文摘 | ANU T ANN-MARI T TIMO K K | 1993 | Mol Microbiol1993，10，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员