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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Pedestrian Self-reports of Factors Influencing the Use of Pedestrian Bridges显示文摘 | Mikko R Timo L Farahnaz A | 2007 | Accident Analysis and Prevention2007，39，： | 1 |
| 3 | Does finn size make a difference? Analysing the effectiveness of R&D subsidies in east Germany 显示文摘 | Bjtirn A Timo M Janina R Gerhard U | 2012 | German Economic Review2012，13，2： | 1 |
| 4 | The role of automated urine particle flow cytometry in clinical practice显示文摘 | Joris R Delanghe Timo T Kouri Andreas R Huber Kurt Hannemann-Pohl Walter G Guder Andreas Lun Pranav Sinha Gudrun Stamminger Lothar Beier | 2000 | Clinica Chimica Acta2000，，1： | 1 |
| 5 | Surgical or Nonoperative Treatment for Lumbar Spinal Stenosis?: A Randomized Controlled Trial显示文摘 | Antti Malmivaara P?r Sl?tis Markku Heli?vaara P?ivi Sainio Heikki Kinnunen Jyrki Kankare Nina Dalin-Hirvonen Seppo Seitsalo Arto Herno Pirkko Kortekangas Timo Niinim?ki Hannu R?nty Kaj Tallroth Veli Turunen Paul Knekt Tommi H?rk?nen Heikki Hurri | 2007 | Spine2007，，1： | 1 |
| 6 | Clinical determinants of poststroke dementia显示文摘 | Tarja P Timo E Ylikoski R | 1998 | Stroke1998，29，： | 1 |
| 7 | Does firm size make a difference? Analysising the effectiveness of R&D subsidies in east Germany 显示文摘 | BJORN A TIMO M JANINA R | 2012 | German Economic Review2012，，2： | 1 |
| 8 | 显示文摘 | Timo thy S Haddad R S Hong G J | 1999 | Polymer Preprints1999，40，1： | 1 |
| 9 | Push/Pull Production Plan and Schedule Used in Modern Refinery CIMS显示文摘 | Xiong Gang Nyberg Timo R | | 0，，： | 1 |
| 10 | Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs显示文摘 | Pekka R Timo K Kai K | 2003 | J Thorac Cardiovasc Surg2003，125，： | 1 |
| 11 | Space aver- aging on a gas-solid drag model for numerical simula- tions of a CFB riser 显示文摘 | SRUJAL S JOUNI R TIMO H | 2012 | Powder Technology2012，218，： | 1 |
| 12 | Rotavirus disease in Finnish children:use of numerical scores for clinical severity of diarroeal episodes显示文摘 | Timo V | 1990 | Scand J Infect Dis1990，22，3： | 1 |
| 13 | Postembryonic development of chicken bursa of Fabricius:A light microscopic hist quantitative study显示文摘 | Timo R | 1982 | Poultry Sci1982，61，： | 1 |
| 14 | Pedestrian self-reports of factors influencing the use of pedestrian bridges显示文摘 | Mikko R Timo L Farahnaz A | 2007 | Accident Analysis and Prevention2007，39，： | 1 |
| 15 | Bretschneider, Semantic - sensitive satellite image retrieval 显示文摘 | LI YIKUN TIMO R | 2007 | IEEE Transactions on Geoscience and RemoteSensing2007，45，4： | 1 |
| 16 | Push/pull production plan and schedule used in modern refinery CIMS 显示文摘 | Gang Xiong Timo R Nyberg | 2000 | Robotics and Computer Integrated Manufacturing2000，，16： | 1 |
| 17 | A kind of agile supply chain system显示文摘 | Nyberg Timo R Guang-Yu Xiong | 2001 | IEEE2001，，： | 1 |
| 18 | Middleware-based Solution for Enterprise Information Integration 显示文摘 | Xiong Gang Timo R Nyberg | 2001 | IEEE2001，，： | 1 |
| 19 | YKL-40 and transient elastography, a powerful team to assess hepatic fibrosis 显示文摘 | Timo R Martin R Can G | 2011 | Scand J Gastroentero2011，46，11： | 1 |
| 20 | YKL-40 and transient elastography,a powerful team to assess hepatic fibrosis 显示文摘 | Timo R Martin R Can G | 2011 | Scand J Gastroenterol2011，46，11： | 1 |
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