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19篇 您的检索式：作者名="Timo E"

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		题名	作者	年代	出处	被引量
	1	Comparison of stroke features and disability in daily life patients with ischemic stroke aged 55 to 70 and 71 to 85 years 显示文摘	Tarja P Timo E Risto V	1997	Stroke1997，28，4：	1
	2	Facile entry to the tetracyclic 5-7-6-3 tigliane ring system显示文摘	Timo V Ovaska Sarah E Reisman Meghan A Flynn	2001	Org Lett2001，3，1：	1
	3	Effect of decentlation and tilt on the image quality of aspherie intraocular lens designsin amodel eye显示文摘	Timo E Katja S	2009	J Cataract Refract Sur2009，35，10：	1
	4	Microbial activity in a sandy arable soil is governed by the fertilization regime显示文摘	Timo K Stephan W Frank E	2004	European Journal of Soil Biology2004，40，：	1
	5	Clinical determinants of poststroke dementia显示文摘	Tarja P Timo E Ylikoski R	1998	Stroke1998，29，：	1
	6	Lipid-lowering drugs and heart failure: where do we go after the statin trials?显示文摘	Timo E Strandberg	2010	Current Opinion in Cardiology2010，，4：	1
	7	Cross-cultural differences in driving behaviors:a comparison of six countries显示文摘	Türkerzkan Timo Lajunen T Joannes E l	2006	Transportation Research Part F:Psychology and Behavior2006，9，3：	1
	8	A joint finite mixture model for clustering genes from independent Gaussian and beta distributed data 显示文摘	Xiao Feng D Timo E OUi Y H	2009	BMC Bioinformatics2009，10，：	1
	9	Numerical Taylor expansions for invariant manifolds 显示文摘	Timo E Jan V P	2004	NumerischeMathematik2004，99，1：	1
	10	Identification of the pro- tein receptor binding site of boblinum neurotoxins B and G proves the double-receptor concept显示文摘	Rummel A Timo E Tanja W	2007	Proc Nail Acad Sci USA2007，104，1：	1
	11	Possibilities of muhifaetofial cardiovascular disease prevention in patients aged 75 and older: a randomized controlled trial Drugs and Evidence Based Medicine in the Elderly (DEBATE) Study 显示文摘	Timo E Strandberg Kaisu Pitkala Saila Berglind	2003	Eur Heart J2003，24，：	1
	12	Effects of prolonged exposure to and physical training in hypobaric conditions on skeletal muscle morphology and metabolic enzymes in rats显示文摘	Merja Perhonen Timo E S Takala Vuokko Kovanen	1996	Pflügers Arch-Eur J Physiol1996，432，：	1
	13	Absorp-tive Capacity and Social Capital in Regional Innovation Systems:The Case of the Lahti Region in Finland显示文摘	Ann e Kallio Vesa Harmaakorpi&Timo Pihkala	2010	Urban Studies2010，47，2：	1
	14	Microbial activity in a sandy arable soil is governed by the fertilization regime显示文摘	Timo K Stephan W Frank E	2004	European Journal of Soil Biology2004，40，2：	1
	15	A joint finite mixture model for clustering genes from independent Gaussian and beta distributed data显示文摘	Xiao Feng D Timo E Olli Y H	2009	BMC Bioinformatics2009，，10：	1
	16	Microbial activity in a sandy arable soilis governed by the fertilization regime显示文摘	Timo K Stephan W Frank E	2004	European Journal of SoilBiology2004，40，2：	1
	17	Subcortical ischaemic vascular dementia显示文摘	Gustavo C R Timo E Anders W	2002	Lancet Neurol2002，11，：	1
	18	Mortality and incidence of cancer during 10-year follow-up of the scandinavian Simvastatin survival study(4S)显示文摘	Timo E S Kalevi P homas J C	2004	Lancet2004，364，11：	1
	19	Traceless enzymatic protein synthesis without ligation sites constraint显示文摘Protein synthesis and semisynthesis offer immense promise for life sciences and have impacted pharmaceutical innovation.The absence of a generally applicable method for traceless peptide conjugation with a flexible choice of junction sites remains a bottleneck for accessing many important synthetic targets,however.Here we introduce the PALME(protein activation and ligation with multiple enzymes)platform designed for sequence-unconstrained synthesis and modification of biomacromolecules.The upstream activating modules accept and process easily accessible synthetic peptides and recombinant proteins,avoiding the challenges associated with preparation and manipulation of activated peptide substrates.Cooperatively,the downstream coupling module provides comprehensive solutions for sequential peptide condensation,cyclization and protein N/C-terminal or internal functionalization.The practical utility of this methodology is demonstrated by synthesizing a series of bioactive targets ranging from pharmaceutical ingredients to synthetically challenging proteins.The modular PALME platform exhibits unprecedentedly broad accessibility for traceless protein synthesis and functionalization,and holds enormous potential to extend the scope of protein chemistry and synthetic biology.	Ruifeng Li Marcel Schmidt Tong Zhu Xinyu Yang Jing Feng Yu’e Tian Yinglu Cui Timo Nuijens Bian Wu	2022	National Science Review2022，9，5：	0

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