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| 1 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://gffzz62a03ee25e6f4a77h09vuux6cfkvo6wo5.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 2 | An expert consensus on the evaluation and treatment of acute thoracolumbar spine and spinal cord injury in China显示文摘This is an expert consensus on the evaluation and treatment of thoracolumbar spinal injury,established from February 2009 to July 2010.The expert consensus consists mainly of six parts with a total of 54 recommendations including the overview(one item);pre-hospital care(one item);evaluation and diagnosis(13 items);treatment(23 items);prevention and treatment of major complications(12 items);and rehabilitation(four items).This is the first time that Chinese experts have published a consensus on spine and spinal cord injury.The expert consensus was established based on Delphi methods,literature analysis,and clinical experiences.Each recommendation is supported by and was interpreted using multi-level evidences.The level of agreement with the recommendation among the panel members was assessed as either low,moderate,or strong.Each panel member was asked to indicate his or her level of agreement on a 5-point scale,with '1' corresponding to neutrality and '5' representing maximum agreement.Scores were aggregated across the panel members and an arithmetic mean was calculated.This mean score was then translated into low,moderate,or strong.After all of the votes were collected and calculated,the results showed no low-level recommendations,10 moderate-level recommendations,and 44 strong-level recommendations.An expert consensus was reached and was recognized by Chinese spine surgeons.Wide-scale adoption of these recommendations is urgent in the management of acute thoracolumbar spine and spinal cord injury in a broader attempt to create a standard evaluation and treatment strategy for acute thoracolumbar spine and spinal cord injury in China. | Zhicheng Zhang Fang Li Tiansheng Sun | 2013 | Neural Regeneration Research2013，8，33： | 6 |
| 3 | Effect of preparation methods on the structure and catalytic performance of Fe–Zn/K catalysts for CO2 hydrogenation to light olefins显示文摘Potassium promoted iron–zinc catalysts prepared by co-precipitation method(C–Fe–Zn/K),solvothermal method(S–Fe–Zn/K)and hydrothermal method(H–Fe–Zn/K)could selectively convert CO_2to light olefins,respectively.The physicochemical properties of the obtained catalysts were determined by SEM,N_2physisorption,XRD,H_2-TPR,CO_2-TPD and XPS measurements.The results demonstrated that preparation methods had great influences on the morphology,phase structures,reduction and adsorption behavior,and hence the catalytic performance of the catalysts.The samples prepared by hydrothermal and co-precipitation method generated small uniform particles and led to lower specific surface area.In contrast,microspheres with larger specific surface area were formed by self-assembly of nanosheets using solvothermal method.ZnFe_2O_4was the only detectable phase in the fresh C–2Fe–1Zn/K,S–3Fe–1Zn/K and S–2Fe–1Zn/K samples.ZnFe_2O_4and ZnO co-existed with increasing Zncontent in S–1Fe–1Zn/K sample,while ZnO and Fe_2O_3could be observed over H–2Fe–1Zn/K sample.All the used samples contained Fe_3O_4,ZnO and Fe_5C_2.The peak intensity of ZnO was strong in the AR-H–2Fe–1Zn/K sample while it was the lowest in the AR-C–2Fe–1Zn/K sample after reaction.The formation of ZnFe_2O_4increased the interaction between iron and zinc for C–2Fe–1Zn/K and S–Fe–Zn/K samples,causing easier reduction of Fe_2O_3to Fe_3O_4.The surface basicity of the sample prepared by co-precipitation method was much more than that of the other two methods.During CO_2hydrogenation,all the catalysts showed good activity and olefin selectivity.The CO selectivity was increased with increasing Zncontent over S–Fe–Zn/K samples.H–2Fe–1Zn/K catalyst preferred to the production of C_5^+hydrocarbons.CO_2conversion of 54.76%and C_2~=–C_4~=contents of 57.38%were obtained on C–2Fe–1Zn/K sample,respectively. | Xu Wang Jianli Zhang Jingyu Chen Qingxiang Ma Subing Fan Tiansheng Zhao | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 6 |
| 4 | Ecological risk assessment of Cd and other heavy metals in soil-rice system in the karst areas with high geochemical background of Guangxi,China显示文摘Karst areas are widely distributed in China,and the soil derived in these areas is enriched with trace elements and has the typical characteristics of high geochemical background.Therefore,soil ecological risk has gradually attracted extensive attention.In this study,1090 sets of rice grains and paired rhizosphere soils were collected as research objects from the outcropped karst areas of carbonate rocks in Guangxi,and the concentration characteristics and influencing factors of heavy metals,such as Cd and As,in rice grains and the corresponding soils were studied.According to the Chinese Soil Environmental Quality Standard(GB 15618-2018),the proportion of karstic soil samples in Guangxi with heavy metal(As,Cd,Cr,Cu,Hg,Ni,Pb and Zn)concentrations that exceed the standard risk screening values was generally greater than that of surface soils in China or non-karstic soils in Guangxi.Notably,Cd and As were the most prominently enriched heavy metals in soils.According to the Chinese Food Safety Standard(GB 2762-2017),Pb in rice grains from the studied area did not exceed the standard;the exceedance rates of Cr,Hg,and inorganic As were only about 1%;and the exceedance rate of Cd was 12.5%.Soil Cd concentration increased gradually whereas the concentration and exceedance rate of Cd in rice grains decreased gradually with the increase of soil pH.Specifically,the exceedance rate of Cd in rice grains was only 4%when soil pH>6.5.The results indicated that the risk screening values of Cd element in the Chinese Soil Environmental Quality Standard are not satisfactorily applicable to the ecological risk assessment of Cd in karstic soils.Therefore,the recommended threshold values for the safe utilization and risk control of Cd in karstic soils was proposed so as to provide a basis for soil environmental quality hierarchization,pollution risk control and land safety zoning of agricultural land in karst areas in China. | Qiong YANG Zhongfang YANG Qizuan ZHANG Xu LIU Xiaoxiong ZHUO Tiansheng WU Lei WANG Xueji WEI Junfeng JI | 2021 | Science China Earth Sciences2021，64，7： | 5 |
| 5 | Treadmill step training promotes spinal cord neural plasticity after incomplete spinal cord injury显示文摘A large body of evidence shows that spinal circuits are significantly affected by training,and that intrinsic circuits that drive locomotor tasks are located in lumbosacral spinal segments in rats with complete spinal cord transection.However,after incomplete lesions,the effect of treadmill training has been debated,which is likely because of the difficulty of separating spontaneous stepping from specific training-induced effects.In this study,rats with moderate spinal cord contusion were subjected to either step training on a treadmill or used in the model(control) group.The treadmill training began at day 7 post-injury and lasted 20 ± 10 minutes per day,5 days per week for 10 weeks.The speed of the treadmill was set to 3 m/min and was increased on a daily basis according to the tolerance of each rat.After 3 weeks of step training,the step training group exhibited a significantly greater improvement in the Basso,Beattie and Bresnahan score than the model group.The expression of growth-associated protein-43 in the spinal cord lesion site and the number of tyrosine hydroxylase-positive ventral neurons in the second lumbar spinal segment were greater in the step training group than in the model group at 11 weeks post-injury,while the levels of brain-derived neurotrophic factor protein in the spinal cord lesion site showed no difference between the two groups.These results suggest that treadmill training significantly improves functional recovery and neural plasticity after incomplete spinal cord injury. | Tiansheng Sun Chaoqun Ye Jun Wu Zhicheng Zhang Yanhua Cai Feng Yue | 2013 | Neural Regeneration Research2013，8，27： | 5 |
| 6 | CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis显示文摘Fatty acid oxidation(FAO)has been proven to be an accomplice in tumor progression.Carnitine palmitoyltransferase 1C(CPT1C),a rate-limiting enzyme in FAO,mainly functions to catalyze fatty acid carnitinylation and guarantee subsequent entry into the mitochondria for FAO in colorectal cancer(CRC).Gene expression data and clinical information extracted from The Cancer Genome Atlas(TCGA)database show significantly higher expression of CPT1C in patients with metastatic CRC(P=0.005).Moreover,overexpression of CPT1C is correlated with worse relapse-free survival in CRC(HR 2.1,P=0.0006),while no statistical significance is indicated for CPT1A and CPT1B.Further experiments demonstrate that downregulation of CPT1C expression leads to a decrease in the FAO rate,suppression of cell proliferation,cell cycle arrest and repression of cell migration in CRC,whereas opposite results are obtained when CPT1C is overexpressed.Furthermore,an FAO inhibitor almost completely reverses the enhanced cell proliferation and migration induced by CPT1C overexpression.In addition,analysis of TCGA data illustrates a positive association between CPT1C expression and HIF1αlevel,suggesting that CPT1C is a transcriptional target of HIF1α.In conclusion,CPT1C overexpression indicates poor relapse-free survival of patients with CRC,and CPT1C is transcriptionally activated by HIF1α,thereby promoting the proliferation and migration of CRC cells. | Jing Li Wanwei Zheng Jie Wu Jun Zhang Bin Lv Wenshuai Li Jie Liu Xin Zhang Tiansheng Huang Zhongguang Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 1 |
| 7 | Does repair of spinal cord injury follow the evolutionary theory?显示文摘Lower vertebrates,such as fish and amphibians,and higher vertebrates in embryonic development can acquire complete regeneration of complex body structures,including the spinal cord,an important part of the central nervous system.However,with species evolution and development,this regenerative capacity gradually weakens and even disappears,but the cellular and molecular mechanisms remain poorly understood.We explored the differences in mechanisms of spinal cord regeneration capability between lower and higher vertebrates,investigated differences in their cellular and molecular mechanisms and between the spinal cord structures of lower vertebrates and mammals,such as rat and monkey,to search for theoretical evidence and therapeutic targets for nerve regeneration in human spinal cord. | Zhicheng Zhang Fang Li Tiansheng Sun | 2012 | Neural Regeneration Research2012，7，11： | 1 |
| 8 | Reservoir prediction using multi-wave seismic attributes显示文摘The main problems in seismic attribute technology are the redundancy of data and the uncertainty of attributes,and these problems become much more serious in multi-wave seismic exploration.Data redundancy will increase the burden on interpreters,occupy large computer memory,take much more computing time,conceal the effective information,and especially cause the 'curse of dimension'.Uncertainty of attributes will reduce the accuracy of rebuilding the relationship between attributes and geological significance.In order to solve these problems,we study methods of principal component analysis (PCA),independent component analysis (ICA) for attribute optimization and support vector machine (SVM) for reservoir prediction.We propose a flow chart of multi-wave seismic attribute process and further apply it to multi-wave seismic reservoir prediction.The processing results of real seismic data demonstrate that reservoir prediction based on combination of PP-and PS-wave attributes,compared with that based on traditional PP-wave attributes,can improve the prediction accuracy. | Ye Yuan Yang Liu Jingyu Zhang Xiucheng Wei Tiansheng Chen | 2011 | Earthquake Science2011，24，4： | 1 |
| 9 | Prediction of fracture characteristic of particle-reinforced alumina-based composites显示文摘Residual microstresses in particle reinforced alumina/SiC and alumina/mullite composites were calcu- lated. The results indicated that there existed a linear relation between matrix microstresses and the particle contents in the composites. The influence of stress state on crack propagating and grain boundary strengthening was analyzed. Ratios of grain boundary toughness to grain toughness of these composites were calculated in view of microstress analysis, and percentage of transgranular fracture (PTF) that increases with the microstress in the alumina matrix was then deduced. The relationship between microstructure, component, matrix microstresses, and PTF was established. Therefore, the fracture characteristic was predicted on basis of the particle content and distribution in addition to the microstructure of the composites. | LUO HaiHui ZHANG FuCheng WANG TianSheng | 2009 | Science China(Technological Sciences)2009，52，4： | 1 |
| 10 | Biologically inspired anthraquinone redox centers and biomass graphene for renewable colloidal gels toward ultrahigh-performance flexible micro-supercapacitors显示文摘Biomass carbon and small redox biomolecules are attractive materials for green,sustainable energy storage devices owing to their environmentally friendly,low-cost,scalable,and novel sources.However,most devices manufactured using these materials have low specific capacitance,poor cycle stability,short lifetime,complexity,and low precision of device fabrication.Herein,we report the directed self-assembly of mononuclear anthraquinone(MAQ)derivatives and porous lignin-based graphene oxide(PLGO)into a renewable colloidal gel through noncovalent interactions.These self-assembled gel electrode materials exhibited high capacitance(484.8 F g^(−1) at a current density of 1 A g^(−1))and could be further printed as flexible micro-supercapacitors(FMSCs)with arbitrary patterns and a relatively high resolution on specific substrates.The FMSCs exhibited excellent areal capacitance(43.6 mF cm^(−2)),energy and power densities(6.1μWh cm^(−2) and 50μW cm^(−2),respectively),and cycle stability(>10,000 cycles).Furthermore,the printed FMSCs and integrated FMSC arrays exhibited remarkable flexibility while maintaining a stable capacitance.The proposed approach can be applied to other quinone biomolecules and biomass-based carbon materials.This study provides a basis for fabricating green and sustainable energy storage device architectures with high capacitance,long-term cycling,high scalability,and high precision. | Tiansheng Wang Shunyou Hu Yuanyuan Hu Dong Wu Hao Wu Jinxu Huang Hao Wang Weiwei Zhao Wen Yu Mi Wang Jie Xu Jiaheng Zhang | 2023 | Journal of Materials Science & Technology2023，，20： | 0 |
| 11 | Mechanistic understanding of the charge storage processes in FeF_(2) aggregates assembled with cylindrical nanoparticles as a cathode material for lithium-ion batteries by in situ magnetometry显示文摘Transition metal fluorides(TMFs)cathode materials have shown extraordinary promises for electrochemical energy storage,but the understanding of their electrochemical reaction mechanisms is still a matter of debate due to the complicated and continuous changing in the battery internal environment.Here,we design a novel iron fluoride(FeF_(2))aggregate assembled with cylindrical nanoparticles as cathode material to build FeF_(2) lithium-ion batteries(LIBs)and employ advanced in situ magnetometry to detect their intrinsic electronic structure during cycling in real time.The results show that FeF_(2) cannot be involved in complete conversion reactions when the FeF_(2) LIBs operate between the conventional voltage range of 1.0–4.0 V,and that the corresponding conversion ratio of FeF_(2) can be further estimated.Importantly,we first demonstrate that the spin-polarized surface capacitance exists in the FeF_(2) cathode by monitoring the magnetic responses over various voltage ranges.The research presents an original and insightful method to examine the conversion mechanism of TMFs and significantly provides an important reference for the future artificial design of energy systems based on spinpolarized surface capacitance. | Zhengqiang Hu Fengling Zhang Huanyu Liang Hao Zhang Huaizhi Wang Tiansheng Wang Renbin Liu Jie Liu Yadong Li Xiaotong Dong Lianyu Bao Zhuan Liang Yaqun Wang Shishen Yan Qiang Li Hongsen Li | 2022 | Carbon Energy2022，4，6： | 0 |
| 12 | Microdefects in Te-Rich PbTe Bulk Crystal显示文摘The microdefects in Te-rich PbTe coating material grown by Bridgman technique have been studied via transmission electron microscopy.The results indicate that the major microdefects in Te-rich PbTe crystal are plate-like defects lying on{100}plane and homogeneously distributed in the matrix with density about 1.7×10^(16)/cm^(3).They are originated from the precipitation of native point defects in Te-rich PbTe which occured in the cooling and annealing process and presented in the form of plates consisting of Te anti-site atoms or interstitial Te atoms. | WANG Geya SHI Tiansheng ZHANG Suying | 1995 | Chinese Physics Letters1995，12，8： | 0 |
| 13 | Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target显示文摘Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3]. | Yingkuan Shao Kailun Xu Xi Zheng Biting Zhou Xiuli Zhang Lin Wang Yaoting Sun Dan Li Ting Chen Jian Wang Shaojun Yu Lifeng Sun Xiaoming Xu Shaozhi Dai Huanhuan Gao Guan Ruan Wei Liu Xue Cai Tiansheng Zhu Lina Qi Jiani Chen Wangxiong Hu Xingyue Weng Yi Zhu Xueping Xiang Zhiyuan Hu Jinfan Li Lirong Chen Jimin Shao Shu Zheng Tiannan Guo | 2022 | Cancer Communications2022，42，2： | 0 |
| 14 | An efficient and mild recycling of waste melamine formaldehyde foams by alkaline hydrolysis显示文摘Melamine formaldehyde foam(MFF)generates many poisonous chemicals through the traditional recycling methods for organic resin wastes.Herein,a high MFF degradation ratio of ca.97 wt.%was achieved under the mild conditions(160℃)in a NaOH–H2O system with ammelide and ammeline as the main degradation products.The alkaline solvent had an obvious corrosion effect for MFF,as indicated by scanning electron microscopy(SEM).The reaction process and products distribution were studied by Fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),and ^(13)C nuclear magnetic resonance(NMR).Besides,the MFF degradation products that have the similar chemical structures and bonding performances to those of melamine can be directly used as the raw material for synthesis of melamine urea-formaldehyde resins(MUFs).Moreover,the degradation system demonstrated here showed the high degradation efficiency after reusing for 7 times.The degradation process generated few harmful pollutants and no pre-or post-treatments were required,which proves its feasibility in the safe removal or recovery of waste MFF. | Shaodi Wu Ning Zhang Chizhou Wang Xianglin Hou Jie Zhao Shiyu Jia Jiancheng Zhao Xiaojing Cui Haibo Jin Tiansheng Deng | 2024 | Green Energy & Environment2024，9，5： | 0 |
| 15 | Twin Domain Fragmentation in YBa_(2)Cu_(3)O_(7-δ) Under Electron Irradiation显示文摘Detwinning and retwinnuig processes in the orthorhombic YBa_(2)Cu_(3)O_(7-δ) have been directly observed under appropriate electron irradiation by transmission electron microscope.These processes can be repeated many times and are accompanied by twin domsdn fragmentation and appreciable increase of twin interface density which is a potential pinning center in YBa_(2)Cu_(3)O_(7-δ),The meaning of this effect in raising J_(c) of the material YBa_(2)Cu_(3)O_(7-δ) is suggested and discussed. | SHI Tiansheng WANG Geya ZHU Jie CHEN Yixing ZHANG Jihua | 1991 | Chinese Physics Letters1991，8，10： | 0 |
| 16 | <100> Textured Diamond Film on Silicon Grown by Hot Filament Chemical Vapor Deposition显示文摘The <100> textured growth of diamond film on HF eroded silicon wafer has been studied by HFCVD. The evolution of grain size and sudece morphology vs deposition time is presented and the <100> textured thick diamond film (80μm) with smooth surface, desirable for practical application in many fields is | Xuanxiong ZHANG Tiansheng SHI and Xikang ZHANG (State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Metallurgy,Chinese Academy of Sciences, Shanghai, 200050, China) | 1995 | Journal of Materials Science & Technology1995，11，6： | 0 |
| 17 | Effects of electron-and hole-current hysteresis on trap characterization in organo-inorganic halide perovskite显示文摘Charge trap density and carrier mobility of perovskite materials are the critical properties of perovskite solar cells.The space charge limited current(SCLC)method,which measures a dark current–voltage(I-V)curve of a single-carrier device has found extensive use for studying the trap density and charge carrier mobility in perovskite materials.Herein,it was found that the electron-and hole-current in organo-lead perovskite-based single-carrier device undergoes significant hysteresis under forward and reverse scanning due to the mobile ions.In addition,it was also observed that measuring history has a detrimental effect on hysteresis resulting in possible overestimation or underestimation of the extracted electrical values from the SCLC measurement.In the forward/reverse scanning process,the mobile ionic defects enhance/shield the charge in the traps due to ionic charging/discharging,thereby increasing/reducing the interface barrier and net charge in the I-V scanning,which in turn affects the determination of transport properties of the carrier.These results raise quite a few doubts over the direct application of classical SCLC measurements for the accurate characterization of intrinsic transport properties of the mixed ionicelectronic perovskite. | Fan Wu Sally Mabrouk Miaomiao Han Yanhua Tong Tiansheng Zhang Yuchen Zhang Raja Sekhar Bobba Quinn Qiao | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
| 18 | Efficient oil-water separation by novel biodegradable all cellulose composite filter paper显示文摘Industrial production and domestic discharge produce a large amount of oily wastewater, which seriously affects the stability of the ecological environment. Membrane separation technology provides another path to treating oily wastewater. And appropriate surface modification of the membrane helps to achieve high efficiency of treating oily wastewater. With green, economy and stability been more concerned.The focal research reports a completely biodegradable all cellulose composite filter paper(ACCFP) composed of Ⅰ-cellulose macrofibers and Ⅱ-cellulose matrix. It is a simple one-step impregnation method to adjust the surface microstructure of the pristine filter paper(PFP), and it does not involve with chemical reaction. The pre-wetted ACCFP consist of Ⅱ-cellulose hydrogel and Ⅰ-cellulose reinforcement in the process of oil-water separation. This layer of hydrogel is the fundamental to underwater superoleophobicity, which determines their eligibility for applications of efficient oil-water mixture or oil-in-water(oil/water) emulsion separation. The separation efficiency of oil-water mixture and oil/water emulsion exceed 95% and 99.9%, respectively. In addition, excellent mechanical properties of ACCFP in dry and wet conditions ensure its stability in service and prolong service life in applications. The focal study provides a new method for high-performance oil-water separation and it is more in line with sustainable chemistry. | Chizhou Wang Shaodi Wu Ning Zhang Zhaoli Jiang Xianglin Hou Long Huang Tiansheng Deng | 2023 | Green Energy & Environment2023，8，6： | 0 |
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