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| 1 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://gffzz62a03ee25e6f4a77h0u9n0cw5wb6o6f55.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 2 | Effects of Annealing on Pt/Co Multilayer Films显示文摘Annealing effects are helpful guides to study Pt/Co multilayer interface diffusions.However,the results reported till now are different.Here we report the increase in coercivity Hc and the decrease in Kerr rotationθk after being annealed in vacuum or argon atmosphere.We attribute these effects to the formation of CoPt3 compound. | JIANG Zhihong SHEN Defang SHI Tiansheng GUO Changlin GUO Rongfa | 1994 | Chinese Physics Letters1994，11，3： | 0 |
| 3 | Microdefects in Te-Rich PbTe Bulk Crystal显示文摘The microdefects in Te-rich PbTe coating material grown by Bridgman technique have been studied via transmission electron microscopy.The results indicate that the major microdefects in Te-rich PbTe crystal are plate-like defects lying on{100}plane and homogeneously distributed in the matrix with density about 1.7×10^(16)/cm^(3).They are originated from the precipitation of native point defects in Te-rich PbTe which occured in the cooling and annealing process and presented in the form of plates consisting of Te anti-site atoms or interstitial Te atoms. | WANG Geya SHI Tiansheng ZHANG Suying | 1995 | Chinese Physics Letters1995，12，8： | 0 |
| 4 | Twin Domain Fragmentation in YBa_(2)Cu_(3)O_(7-δ) Under Electron Irradiation显示文摘Detwinning and retwinnuig processes in the orthorhombic YBa_(2)Cu_(3)O_(7-δ) have been directly observed under appropriate electron irradiation by transmission electron microscope.These processes can be repeated many times and are accompanied by twin domsdn fragmentation and appreciable increase of twin interface density which is a potential pinning center in YBa_(2)Cu_(3)O_(7-δ),The meaning of this effect in raising J_(c) of the material YBa_(2)Cu_(3)O_(7-δ) is suggested and discussed. | SHI Tiansheng WANG Geya ZHU Jie CHEN Yixing ZHANG Jihua | 1991 | Chinese Physics Letters1991，8，10： | 0 |
| 5 | <100> Textured Diamond Film on Silicon Grown by Hot Filament Chemical Vapor Deposition显示文摘The <100> textured growth of diamond film on HF eroded silicon wafer has been studied by HFCVD. The evolution of grain size and sudece morphology vs deposition time is presented and the <100> textured thick diamond film (80μm) with smooth surface, desirable for practical application in many fields is | Xuanxiong ZHANG Tiansheng SHI and Xikang ZHANG (State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Metallurgy,Chinese Academy of Sciences, Shanghai, 200050, China) | 1995 | Journal of Materials Science & Technology1995，11，6： | 0 |
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