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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection显示文摘A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up. | Thorsten Brechmann Justyna Swol Veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 3 | Puff-by-puff resolved characterization of cigarette mainstream smoke by single photon ionization (SPI)-time-of-flight mass spectrometry (TOFMS): Comparison of the 2R4F research cigarette and pure Burley, Virginia, Oriental and Maryland tobacco cigarettes显示文摘 | THOMAS A STEFAN M THORSTEN S | 2006 | Analytica Chimica Acta2006，572，2： | 1 |
| 4 | The influence of positive end-expiratory pressure on stroke volume variation and central blood volume during open and closed chest conditions 显示文摘 | Kubitz JC Thorsten A Kemming GI | 2006 | Eur J Cardiothoracic Surg2006，30，1： | 1 |
| 5 | New data- base on the structure and development of the financial sector显示文摘 | Thorsten B Demirguc - Kunt A Levine R | 2000 | World Bank Economic Review2000，14，3： | 1 |
| 6 | An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement 显示文摘 | Volker A Thorsten B Peter S | 2004 | Biomaterials2004，25，18： | 1 |
| 7 | Micro- vascular reperfusion iniury: rapid expansion of ana- tomic no-reflow During reperfusion in the rabbit显示文摘 | REFELMAN N THORSTEN ROBERT A | 2002 | Am J Pbysiol Heart Cite Physiol2002，283，： | 1 |
| 8 | Crosstalk between the canonical NF-[kappa]B and Notch signaling pathways inhibits Ppar[gamma] expression and promotes pancreatic cancer progression in mice显示文摘 | Maniati Eleni Bossard Maud Cook Natalie Candido Juliana B Emami-Shahri Nia Nedospasov Sergei A Balkwill Frances R Tuveson David A Hagemann Thorsten | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 9 | Survival and growth of Francisella tularensis in Acanthamoeba castellanii显示文摘 | Hadi A Thorsten J lgor G | 2003 | Appl Environ Microbiol2003，1，： | 1 |
| 10 | A simple statistical method for use in kinetic analysis based on Lineweaver- Burk plots 显示文摘 | Thorsten A F James J S | 1977 | Analytical chemistry1977，80，1： | 1 |
| 11 | Archaeal genetics--the third way显示文摘 | THORSTEN A MOSHE M | 2005 | Nature Reviews Genetics2005，6，： | 1 |
| 12 | Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit 显示文摘 | Reffelmann Thorsten Robert A | 2002 | Am J Physiol Heart Circ Physiol2002，283，3： | 1 |
| 13 | The serum protein α 2-HS glycoprotein fetuin inhibits apatite formation in vitro and in mineralizing calvaris cells显示文摘 | Christian A Andreas T | 1996 | J Biol Chem1996，271，20： | 1 |
| 14 | Mitochondrial DNA deletion and the aging heart显示文摘 | Salah A Mohamed Thorsten Hanke ArminW etal | 2006 | Experimental Gerontology2006，41，5： | 1 |
| 15 | Transthoracic echocardiography in rats:Evalution of commonly used indices of left ventricular dimensions,contractile performance and hypertrophy in a genetic model of hypertrophic heart failure (SHHF-Mcc-facp-Rats) in comparison with Wistar rats during aging显示文摘 | Thorsten R Robert A Kloner C | 2003 | Basic Res Cardiol2003，98，： | 1 |
| 16 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 17 | 《Bank Financing for SMEs:Evidence Across Countries and Bank Ownership Types》显示文摘 | Thorsten Beck&Asli Demirgü-Kunt&María Soledad Martínez Pería | 2011 | 《Financ Serv Res》20112011，2011，： | 1 |
| 18 | Mantle dynamics in the Mediterranean显示文摘 | Faccenna Claudio Becker Thorsten W Auer Ludwig Billi Andrea Boschi Lapo Brun Jean Pierre Capitanio Fabio A Funiciello Francesca Horvath Ferenc Jolivet Laurent Piromallo Claudia Royden Leigh Rossetti Federico Serpelloni Enrico | 2014 | Reviews of Geophysics2014，，3： | 1 |
| 19 | 3D structure of Alzheimer’s amyloid-β(1-42)fibrils显示文摘 | THORSTEN L H CHRISTIANE Rr MARE A | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，17： | 1 |
| 20 | LogP:Towards a realistic model of parallel computation显示文摘 | David E Culler Richard M Karp David A Patterson Abhijit Sahay Klaus E Schauser Eunice Santos Ramesh Subramonian Thorsten von Eicken | 1993 | Principles Practice of Parallel Programming1993，，： | 1 |
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