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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Lithium beyond psychiatric indications:the reincarnation of a new old drug显示文摘Lithium has been used in the treatment of bipolar disorders for decades,but the exact mechanisms of action remain elusive to this day.Recent evidence suggests that lithium is critically involved in a variety of signaling pathways affecting apoptosis,inflammation,and neurogenesis,all of which contributing to the complex pathophysiology of various neurological diseases.As a matter of fact,preclinical work reports both acute and longterm neuroprotection in distinct neurological disease models such as Parkinson’s disease,traumatic brain injury,Alzheimer’s disease,and ischemic stroke.Lithium treatment reduces cell injury,decreasesα‑synuclein aggregation and Tau protein phosphorylation,modulates inflammation and even stimulates neuroregeneration under experimental conditions of Parkinson’s disease,traumatic brain injury,and Alzheimer’s disease.The therapeutic impact of lithium under conditions of ischemic stroke was also studied in numerous preclinical in vitro and in vivo studies,giving rise to a randomized double-blind clinical stroke trial.The preclinic data revealed a lithium-induced upregulation of anti-apoptotic proteins such as B-cell lymphoma 2,heat shock protein 70,and activated protein 1,resulting in decreased neuronal cell loss.Lithium,however,does not only yield postischemic neuroprotection but also enhances endogenous neuroregeneration by stimulating neural stem cell proliferation and by regulating distinct signaling pathways such as the RE1-silencing transcription factor.In line with this,lithium treatment has been shown to modulate postischemic cytokine secretion patterns,diminishing microglial activation and stabilizing blood-brain barrier integrity yielding reduced levels of neuroinflammation.The aforementioned observations culminated in a first clinical trial,which revealed an improved motor recovery in patients with cortical stroke after lithium treatment.Beside its well-known psychiatric indications,lithium is thus a promising neuroprotective candidate for the aforementioned neurological diseases.A detailed understanding of the lithium-induced mechanisms,however,is important for prospective clinical trials which may pave the way for a successful benchto-bedside translation in the future.In this review,we will give an overview of lithiuminduced neuroprotective mechanisms under various pathological conditions,with special emphasis on ischemic stroke. | Matteo Haupt Mathias Bähr Thorsten R.Doeppner | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 3 | Colloid and heavy metal transport at landfill sites in direct contact with groundwater显示文摘 | Thomas B Peter F Thorsten K | 2006 | Water Research2006，40，14： | 1 |
| 4 | Current evidence for transurethral laser therapy of non-muscle invasive bladder cancer 显示文摘 | Mario W K Thorsten B Mathias W | 2011 | World J Urol2011，29，4： | 1 |
| 5 | Aluminium content of selected foods and food products 显示文摘 | Thorsten S Hasan T Hubertus B | 2011 | Environ Sci Europe2011，23，1： | 1 |
| 6 | Autosomal dominant cerebellar ataxias:clinical features genetics and pathogenesis显示文摘 | Ludger S Peter B Thorsten S | 2004 | Lancet Neurol2004，3，： | 1 |
| 7 | New data- base on the structure and development of the financial sector显示文摘 | Thorsten B Demirguc - Kunt A Levine R | 2000 | World Bank Economic Review2000，14，3： | 1 |
| 8 | The Arabidopsis BODENLOS gene encodes an auxin response protein inhibi-ting MONOPTEROS-mediated embryo patterning显示文摘 | THORSTEN H EVA B ISABEL B | 2002 | Genes & Development2002，14，13： | 1 |
| 9 | Financial Intermediary Development and Growth Volatility:Do Intermediaries Dampen Ormagnify Shocks?显示文摘 | THORSTEN B MATTIAS L GIOVANNI M | 2006 | Journal of International Money and Finance2006，25，： | 1 |
| 10 | An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement 显示文摘 | Volker A Thorsten B Peter S | 2004 | Biomaterials2004，25，18： | 1 |
| 11 | Composition-dependent band gap in ZnS x Se 1? x : a combined experimental and theoretical study显示文摘 | Thorsten Homann Urte Hotje Michael Binnewies Alexander B?rger Klaus-Dieter Becker Thomas Bredow | 2005 | Solid State Sciences2005，，1： | 1 |
| 12 | Diagnostic accuracy of dual-source multi-slice CT-cornnary angiography in patients with an intermediate pretest likelihood for coronary artery disease显示文摘 | Alexander WL Thorsten J Alexander B | 2007 | Eur Heart J2007，28，19： | 1 |
| 13 | The preferred treatment for upper tract stones is extracorporeal shock wave lithotripsy(ESWL) or uretero- scopic: pro ESWL显示文摘 | Christian C Thorsten B | 2009 | Urology2009，74，2： | 1 |
| 14 | Structural Bonding Tape: An innovation in adhesive bonding显示文摘 | GREGG B JURGEN K PAUL L G THORSTEN N | 1996 | Adhesives Age1996，，9： | 1 |
| 15 | The preferred treatment for upper tract stones is extracorporeal shock wave lithotripsy (ESWL) or ureteroscopic: pro ESWL显示文摘 | Christian C Thorsten B | 2009 | Urology2009，74，2： | 1 |
| 16 | Diagnostic accuracy of duaL-source computed tomography in the diagnosis of coronary artery disease显示文摘 | Thorsten RCJ Konstantin N Stephanie B | 2007 | Invest Radiol2007，42，10： | 1 |
| 17 | Crosstalk between the canonical NF-[kappa]B and Notch signaling pathways inhibits Ppar[gamma] expression and promotes pancreatic cancer progression in mice显示文摘 | Maniati Eleni Bossard Maud Cook Natalie Candido Juliana B Emami-Shahri Nia Nedospasov Sergei A Balkwill Frances R Tuveson David A Hagemann Thorsten | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 18 | An inverted triplesalen ligand by a convergent synthesis and its influence on trinuclear Fe_3~Ⅲ complexes显示文摘The inverted triplesalen ligand H 6 feld Me has been synthesized from 2,4,6-triformyl-phloroglucinol and a ketimine salen half-unit in a convergent synthesis. NMR, IR, and UV-vis spectroscopy reveal that this ligand is not in the O-protonated tautomer but in the N-protonated tautomer with substantial heteroradialene contribution. This ligand and the conventional triplesalen ligand H 6 talen t-Bu 2 have been used to synthesize the trinuclear Fe III complexes [(feld Me )(FeCl) 3 ] and [(talen t-Bu 2 )(FeCl) 3 ], respectively. The molecular structures of these complexes were obtained by single-crystal X-ray diffraction. Two trinuclear Fe III complexes of [(feld Me )(FeCl) 3 ] dimerize via two Fe-phenolate bonds, whereas due to steric hindrance no dimerization is observed for [(talen t-Bu 2 )(FeCl) 3 ]. The structural data also reveal some heteroradialene contribution in the trinuclear complexes. Whereas UV-vis and M bauer spectroscopy are not suitable to distinguish between the two complexes, FT-IR spectra show characteristic features due to the different substitution patterns of the conventional and the inverted triplesalen ligands. Another handle is provided by electrochemistry. Whereas both complexes exhibit an irreversible oxidation wave (0.94 V vs. Fc + /Fc for [(feld Me )(FeCl) 3 ] and 0.84 V vs. Fc + /Fc for [(talen t-Bu 2 )(FeCl) 3 ]), which is assigned to the oxidation of the central backbone, higher potential oxidations are reversible for [(talen t-Bu 2 )(FeCl) 3 ]) but irreversible for [(feld Me )(FeCl) 3 ]. This is attributed to the reversible oxidation of the terminal phenolates in the di-tert-butyl substituted [(talen t-Bu 2 )(FeCl) 3 ] in contrast to the mono-methyl-substituted phenolates in [(feld Me )(FeCl) 3 ]. The magnetic properties of [(talen t-Bu 2 )(FeCl) 3 ] reveal a very small ferromagnetic coupling with significant zero-field splitting of the FeⅢ S = 5/2 ions. In contrast, the dimerization of two trinuclear complexes in [(feld Me )(FeCl) 3 ] results in antiferromagnetic interactions between the two phenolate-bridged Fe III ions, which mask the intra-trinuclear interactions transmitted by the central phloroglucinol backbone. | FELDSCHER Bastian KRICKEMEYER Erich MOSELAGE Marc THEIL Hubert HOEKE Veronika KAISER Yvonne STAMMLER Anja BGGE Hartmut GLASER Thorsten | 2012 | Science China Chemistry2012，55，6： | 1 |
| 19 | Financial intermediary development and growth volatility: Do intermediaries dampen or magnify shocks? 显示文摘 | Thorsten B Mattias L Giovanni M | 2006 | Journal of International Money and Finance2006，25，： | 1 |
| 20 | Viral Infections in Septic Shock (VISS-Trial) Crosslinks Between Inflammation and Imm unosuppression显示文摘 | Thorsten B Claudia R Isabelle H | 2012 | Journal of Surgical Research2012，176，2： | 1 |
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