|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 2 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 3 | New Firm Formation and Industry Growth:Does Having a Market-or Bank-Based System Matter显示文摘 | Beck Thorsten Levine R | | 0，，： | 1 |
| 4 | Cerebral air embolism after pleural streptokinase instillation显示文摘 | Thorsten K Ullrich J Rüdger S | 2013 | Diving Hyperbaric Med2013，43，4： | 1 |
| 5 | New data- base on the structure and development of the financial sector显示文摘 | Thorsten B Demirguc - Kunt A Levine R | 2000 | World Bank Economic Review2000，14，3： | 1 |
| 6 | Disabling low back pain and depressive symptoms in the community-dwelling elderly显示文摘 | Thorsten M James C Heiner R | 2007 | Spine2007，32，21： | 1 |
| 7 | Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2,matrix metallo- proteinase-2/9, and RhoA overactivation显示文摘 | Ayman Elali Thorsten R Doeppner Anil Zechariah | 2011 | Stroke2011，42，11： | 1 |
| 8 | Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation显示文摘 | Andreas Goette Thorsten Staack Christoph R?cken Marco Arndt J.Christoph Geller Christof Huth Siegfried Ansorge Helmut U Klein Uwe Lendeckel | 2000 | Journal of the American College of Cardiology2000，，6： | 1 |
| 9 | Disabling low back pain and depressive symptoms in the community-dwelling elderly显示文摘 | Thorsten M James C Heiner R | 2007 | Spine2007，32，21： | 1 |
| 10 | Crosstalk between the canonical NF-[kappa]B and Notch signaling pathways inhibits Ppar[gamma] expression and promotes pancreatic cancer progression in mice显示文摘 | Maniati Eleni Bossard Maud Cook Natalie Candido Juliana B Emami-Shahri Nia Nedospasov Sergei A Balkwill Frances R Tuveson David A Hagemann Thorsten | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 11 | Color image segmentation in HSI space for automotive applications显示文摘 | Calin R Thorsten G Jianwei Z | 2008 | Journal of Real-time Image Processing2008，3，4： | 1 |
| 12 | New applications for noninvasive cardiac imaging: dual-source computed tomography显示文摘 | Carsten R Thorsten R J Christoph RB | 2007 | Eur Radiol2007，17，6： | 1 |
| 13 | Viral Infections in Septic Shock (VISS-Trial) Crosslinks Between Inflammation and Imm unosuppression显示文摘 | Thorsten B Claudia R Isabelle H | 2012 | Journal of Surgical Research2012，176，2： | 1 |
| 14 | Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia显示文摘Inflammation plays an important role in the pathological process of ischemic stroke,and systemic inflammation affects patient prognosis.As resident immune cells in the brain,microglia are significantly involved in immune defense and tissue repair under various pathological conditions,including cerebral ischemia.Although the differentiation of M1 and M2 microglia is certainly oversimplified,changing the activation state of microglia appears to be an intriguing therapeutic strategy for cerebral ischemia.Recent evidence indicates that both mesenchymal stem cells(MSCs)and MSC-derived extracellular vesicles(EVs)regulate inflammation and modify tissue repair under preclinical stroke conditions.However,the precise mechanisms of these signaling pathways,especially in the context of the mutual interaction between MSCs or MSC-derived EVs and resident microglia,have not been sufficiently unveiled.Hence,this review summarizes the state-ofthe-art knowledge on MSC-and MSC-EV-mediated regulation of microglial activity under ischemic stroke conditions with respect to various signaling pathways,including cytokines,neurotrophic factors,transcription factors,and microRNAs. | Wen-Qiang Xin Wei Wei Yong-Li Pan Bao-Long Cui Xin-Yu Yang Mathias Bähr Thorsten R Doeppner | 2021 | World Journal of Stem Cells2021，13，8： | 1 |
| 15 | The effect of steroids in combina- tion with optic nerve decompression surgery in traumatic optic neuropathy显示文摘 | Thorsten R Bernhard S Cem M | 2013 | Laryngoscope2013，123，5： | 1 |
| 16 | Al2O3-ZrO2质风口衬套渣侵蚀SEM分析显示文摘以白刚玉、锆英石为原料制备了Al2O3-ZrO2质风口衬套样,采用静态熔渣法在1500℃保温2h进行高炉渣侵蚀试验。对侵蚀后的试样进行SEM分析,并研究其侵蚀机理。结果表明:侵蚀试样从热面到冷面侵蚀区域主要分为两层,且CaO含量逐渐减少,SiO2含量增多。在试验条件下,锆英石在碱金属Na存在的条件下容易分解生成ZrO2和SiO2;同时,SiO2、Al2O3与渣中CaO反应生成低熔点玻璃相物质,使材料的耐火度降低。 | 王强 龙世刚 Thorsten Tonnesen R Telle 汪志全 路飞 | 2008 | 耐火材料2008，42，2： | 1 |
| 17 | Solid-liquid equlibria of several binary systems with organic compounds 显示文摘 | Lohmam J Thorsten R Gemhling J | 1998 | J Chem Eng Data1998，43，： | 1 |
| 18 | Determination of benzotriazole corrosion in- hibitors from aqueous environmental samples by liquid ehromatog- raphy-electrospray ionization-tandem mass spectrometry 显示文摘 | Stefan W Thorsten R | 2005 | Anal Chem2005，77，： | 1 |
| 19 | Occurrence, sources, and fate of benzothiazoles in municipal wastewater treatment plants 显示文摘 | Achim K Martin J Thorsten R | 2005 | Envi- ron Sci Techno12005，39，： | 1 |
| 20 | Isolation of hydroxycirmamoyltartaric acids from grape pomace by high-speed counter-current chromatography显示文摘 | Thorsten M Solvelgh S Dietmar R K | 2006 | Journal of Chromatography A2006，1128，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员