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| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | Diurnal Variation in Relative Photosynthetic Performance of Marestail (Hippuris vulgaris Linn.) Across a Water Temperature Gradient using PAM Fluorometry in Jiuzhaigou National Nature Reserve,Sichuan Province,China显示文摘This paper reports the first photosynthetic study of marestail in Jiuzhaigou.In this work,we used PAM fluorometry to examine photosynthetic rates of submerged and emerged marestail in three lakes.Three lakes were studied across a gradient of water temperature,with low water temperature conditions in Grass Lake and Arrow Bamboo Lake,and higher water temperature in Five Colored Lake.In the field,electron transport rates (ETRmax) were measured as rapid light curves (RLCs) by in situ yield measurements.Submerged and emerged marestail showed higher photosynthetic activity in Five Colored Lake compared to the other lakes,a response consistent with the adaptation of marestail in Five Colored Lake to high water temperature.The optimal temperature for photosynthesis of submerged marestail in Jiuzhaigou was about 12 °C.Non-photochemical quenching (NPQ) of submerged and emerged marestail increased with increasing water temperature.Maximum quantum yield (Fv/Fm) of submerged marestail in Five Colored Lake showed full recovery at 1700 h due to higher NPQ.Further,the chlorophyll a for submerged marestail was the highest in Grass Lake and the lowest in Five Colored Lake.These results indicate that in different lakes the function of these aquatic plants is associated with a diversity of place-dependent environmental conditions,especially water temperature that leads to pronounced differences in the plant's ecophysiological reactions. | GAO Linan TANG Ya Carla BOSSARD WANG Yan HAN Zhiguo | 2011 | Journal of Mountain Science2011，8，6： | 2 |
| 3 | 盐皮质激素受体拮抗剂或许可降低急性心肌梗死后的患者死亡率显示文摘目的:盐皮质激素受体拮抗剂(MRAs)对合并有心肌梗死(MI)的心衰患者疗效确切,能够降低其死亡率,但是MRAs对全部MI患者的疗效仍不明确,本文研究的目的是对此进行探讨。 | 何侃 Bossard M Binbraik Y Geygui F | 2018 | 国际老年医学杂志2018，39，3： | 2 |
| 4 | SREBP transcription factors: master regulators of lipid homeostasis显示文摘 | Delphine Eberlé Bronwyn Hegarty Pascale Bossard Pascal Ferré Fabienne Foufelle | 2004 | Biochimie2004，，11： | 2 |
| 5 | Vertebral tumors and pseudotumors显示文摘 | Lared JD Quessar AE Bossard P | 2001 | Radiologic Clinics of North America2001，39，： | 1 |
| 6 | Mechanism of inhibition of cathepsin K by potent, selective 1, 5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases 显示文摘 | Bossard M J Tomaszek T A Levy M A | 1999 | Biochemistry1999，38，15： | 1 |
| 7 | SREBP transcription factors:master regulators of lipid homeostasis显示文摘 | HEGARTY B BOSSARD P | 2004 | Biochimie2004，86，11： | 1 |
| 8 | Design of potent and selective human cathepsin K inhibitors that span the active site显示文摘 | Thompson SK Halbert SM Bossard MJ | 1997 | Proc Natl Acad Sci USA1997，94，14： | 1 |
| 9 | Plasmacytoid dendritic cells and Th17 immune response contribution in gastrointestinal acute graft-versus-host disease显示文摘 | Bossard C Malard F Gaugler B | 2012 | Leukemia2012，26，7： | 1 |
| 10 | Use of an emboli containment and retrieval system during percutaneous coronary angioplasty in native coronary arteries显示文摘 | Sutsch G Kiowski W Bossard A | 2002 | J Invasive Cardiol2002，14，： | 1 |
| 11 | 1 Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | GUIGNARD B BOSSARD AE COSTE C eta | 2000 | Anesthesiology2000，93，2： | 1 |
| 12 | SREBP transcription factors:master regulators of lipid homeostasis显示文摘 | Eberle D Hegarty B Bossard P | | 0，，： | 1 |
| 13 | Vertebral tumors and pseudotumors显示文摘 | Laredo JD Quessar A Bossard P | 2001 | Radiol Clin North Am2001，39，： | 1 |
| 14 | SREBP transcription factors : mas- ter regulators of lipid homeostasis 显示文摘 | Eberle D Hegarty B Bossard P | 2004 | Bioehimie2004，86，11： | 1 |
| 15 | Acute opioid tolerance :in- traoperativc remifentanil increases postoperative pain and morphine re- quirement显示文摘 | Guignard B Bossard AE Coste C | 2012 | Anesthesiology2012，939，2： | 1 |
| 16 | The design and fabrication of planar multiband metallodielectric fre- quency selective surfaces for infrared applications 显示文摘 | Bossard J A Werner D H Mayer T S | 2006 | IEEE Transactions on Antennas and Propagation2006，54，4： | 1 |
| 17 | Tunable frequency selective surfaces and negative-zero-positive index metamaterials based on liquid crystals显示文摘 | Bossard J A | 2008 | IEEE Trans on Antennas and Propagation2008，56，5： | 1 |
| 18 | Acute opioid tolerance: in- traoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | Guignard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 19 | Effects of ketorolac versus bupivaeaine coadministration during patient-controlled hydromorphone epidur analgesia after thoracotomy procedms 显示文摘 | Singh H Bossard RF White PF | 1997 | Aneslh Analg1997，84，3： | 1 |
| 20 | Ten- year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy 显示文摘 | Hennequin C Bossard N Servagi-Vernat S | 2013 | Int J Ra- diat Oncol Biol Phys2013，86，5： | 1 |
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