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| 1 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 2 | Homology between HBV-DNA and a sequence regulating the interferon-induced antiviral system: possible mechanism of persistent infection显示文摘 | Thomas HC Pignatelli M Lever AM | 1986 | J Med Virol1986，19，1： | 1 |
| 3 | The role of colonoscopic endoanal ultrasound scanning (EUS) in selecting patients suitable for resection by transanal endoscopic microsurgery (TEM)显示文摘 | Glancy DG Pullyblank AM Thomas MG | 2005 | Colorectal Dis2005，7，2： | 1 |
| 4 | Non-viral gene therapy: polycation-mediated DNA delivery显示文摘 | Thomas M Kilibaoov AM | 2003 | Applied Microbiology and Biotechnology2003，62，1： | 1 |
| 5 | Optical access trocar injuries in urological laparoscopic surgery 显示文摘 | Thomas MA Rha KH Ong AM | 2003 | J Urol2003，170，1： | 1 |
| 6 | Genetic reductionof group 1 metabotropic glutamate receptors altersselect behaviors in a mouse model for fragile X syndrome显示文摘 | THOMAS AM BUI N GRAHAM D | 2011 | Behav Brain Res2011，223，2： | 1 |
| 7 | Sleep and Anxiety Disorders 显示文摘 | Thomas AM | 2006 | Psychiatric Clinics of North Americ2006，29，4： | 1 |
| 8 | International Surveillance of Candida spp and Aspergillus spp: report from the SENTRY Antimicrobial Surveillance Program ( 2003 ) 显示文摘 | Shawn AM Ronald NJ Thomas RF | 2006 | J Clin Microbiol2006，，： | 1 |
| 9 | Growth factor induced acceleration of tissue repair through direct and inductive activities in a rabbit dermalulcer model显示文摘 | Thomas AM Glenn FP | 1991 | Clin Invest1991，，87： | 1 |
| 10 | Major depression after breast cancer:a review of epidemiology and treatment 显示文摘 | Farm JR Thomas Rich AM Katon WJ | 2008 | Gen Hesp Psychiatry2008，30，2： | 1 |
| 11 | Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro显示文摘 | Andersen HR Vinggaard AM Thomas H?j Rasmussen | 2002 | Toxicol appl pharmacol2002，179，： | 1 |
| 12 | Validation of X-ray fluorescence spectrometry for determining osseous or dental origin of unknown material显示文摘 | Christensen AM Smith MA Thomas RM | | 0，，01： | 1 |
| 13 | Amphotericin B and fluconazole,a potent combination therapy for cryptococcal meningitis显示文摘 | Larsen RA Bauel M Thomas AM | 2004 | Antimicrobial Agents and Chemotherapy2004，，： | 1 |
| 14 | Postoperative Pain Facilitates Nonthermoregulatory Tremor显示文摘 | Ernst-Peter Horn Frank Schroeder Stefan Wilhelm Daniel I. Sessler Thomas Standl Katja von dem Busche Jochen Schulte am Esch | 1999 | Anesthesiology1999，，4： | 1 |
| 15 | Elimination of infection in pulpectomized deciduous teeth:a short time study using of iodoform paste显示文摘 | Thomas AM | 1994 | J Endod1994，20，5： | 1 |
| 16 | Lethal damage to endothelial cell by oxidized low density lipoprotein:role of selenoperoxidases in cyctoprotection against lipid hydroperoxide - and iron - mediated reactions显示文摘 | Thomas JP Ceiger PG and Girotti AM | 1993 | J Lipid Res1993，34，： | 1 |
| 17 | Age-related loss of distortion product otoacoustic emissions in four mouse strains显示文摘 | Jimenez AM Stagner BB Thomas C | 1999 | Hear Res1999，138，： | 1 |
| 18 | Killing of trypanosomatid parasites by a modified bovine host defense peptide, BMAP- 18 显示文摘 | Haines LR Thomas JM Jackson AM | 2009 | PIoS Negl Trop Dis2009，3，2： | 1 |
| 19 | Amiodarone and bepridil inhibit anthrax toxin entry into host cells显示文摘 | Sanchez AM Thomas D Gillespie EJ | 2007 | Antimicrobial Agents and Chemotherapy2007，51，7： | 1 |
| 20 | Alanine-glutamine dipeptide(AGD) inhibits expression of inflammation-related genes in hemorrhagic shock显示文摘 | Yang R Tan X Thomas AM | 2007 | Jpen2007，31，1： | 1 |
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