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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Risk factors, surgical complications and graft survival in liver transplant recipients with early allograft dysfunction显示文摘Background: Early allograft dysfunction (EAD) is a severe complication after liver transplantation. The associated risk factors and complications have re-gained recent interest. This study investigated risk factors, survival and complications associated with EAD in a large liver transplant center in Latin America. Methods: Retrospective, unicenter, cohort, based on data from adult patients undergoing first deceaseddonor liver transplant from January 2009 to December 2013. EAD was defined by one or more of the following:(i) bilirubin ≥10 mg/dL on postoperative day 7;(ii) international normalized ratio ≥1.6 on postoperative day 7, and (iii) alanine aminotransferase or aspartate aminotransferase > 2000 IU/L within the first seven days after transplant. Results: A total of 602 patients were included;of these 34.2% developed EAD. Donor risk factors were male ( P = 0.007), age between 50 and 59 years ( P = 0.034), overweight ( P = 0.028) or grade I obesity ( P = 0.012), sodium > 157 mmol/L ( P = 0.002) and grade IV ischemia/reperfusion injury ( P = 0.002). Cold ischemia time ≥10 h ( P = 0.008) and warm ischemia time ≥40 min ( P = 0.013) were the surgical factors. Male ( P < 0.001) was the only recipient protective factor. Compared with the non-EAD group, patients with EAD were submitted to more reoperations (24.3% vs. 13.4%, P = 0.001) and had higher graft loss rates (37.9% vs. 21.2%, P < 0.001), with similar patient survival rates ( P = 0.238). Conclusions: EAD risk factors are related to donor, surgical procedure and recipient. Donor risk factors for EAD were male, age between 50 and 59 years, donor overweight or grade Ⅰ obesity, sodium > 157 mmol/L and grade Ⅳ ischemia/reperfusion injury. Cold ischemia time ≥10 h and warm ischemia time ≥40 min were the surgical risk factors. Male was the only recipient protective factor. Patients with EAD had higher reoperations and graft loss rates. | Douglas Bastos-Neves Paolo Rogerio de Oliveira Salvalaggio Marcio Dias de Almeida | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 15 |
| 3 | New Insights into Aluminum Tolerance in Rice: The ASR5 Protein Binds the STAR1 Promoter and Other Aluminum-Responsive Genes显示文摘在植物的铝(艾尔) 毒性是在庄稼生产的主要限制之一。艾尔 3+, 最艾尔的有毒的形式,在酸的条件和原因下面被释放进土壤植物的广泛的损坏, especiallyin 根。在米饭,艾尔忍耐要求 ASR5 基因,而是 ASR5 的分子的功能仍然保持未知。这里,我们执行染色体宽的分析在米饭识别 ASR5-dependentAl-responsive 基因。在植物把 silencing 基于 ASR5_RNAi,全球 transcriptome 分析识别了全部的 of961 对在野类型的米饭根的艾尔处理应答的基因。这些基因, 909 没在 ASR5_RNAiplants 对艾尔作出回应,显示为在 Al 应答的基因表示的 ASR5 的一个中央角色。在正常条件下面,没有艾尔处理, ASR5_RNAi 植物与野类型的植物相比表示了 1.756 基因差别,并且在野类型的植物的 446 这些基因 respondedto 艾尔处理。深定序跟随的染色质 immunoprecipitation 识别了被对他们的倡导者有约束力的 ASR5 直接调整的 104 putativetarget 基因,包括 STAR1 基因,它编码为艾尔忍耐要求的 ABC transporter。有约束力的山峰序列的主题分析为 ASR5 揭示了 thebinding 主题,它在 vitro 被证实经由用 STAR1 倡导者的 DNA 有约束力的试金。这些结果证明 ASR5 充当在 rice.Key 词为 Al 应答的 geneexpression 和艾尔忍耐是必要的一个关键抄写因素: | Rafael Augusto Arenhart Yang Bai Luiz Felipe Valter de Oliveira Lauro Bucker Neto Mariana Schunemann Felipe dos Santos Maraschin Jorge Mariath Adriano Silverio Gilberto Sachetto-Martins Rogerio Margis Zhi-Yong Wang Marcia Margis-Pinheiro | 2014 | Molecular Plant2014，7，4： | 12 |
| 4 | Benefits of Biochars and NPK Fertilizers for Soil Quality and Growth of Cowpea (Vigna unguiculata L. Walp.) in an Acid Arenosol显示文摘Fertilization is required for optimum plant growth, particularly in unfertile soils, while optimizing nutrient use effciency is an alternative to reduce inorganic fertilizer needs and reduce environmental problems caused by nutrient leaching. This study investigated soil properties and cowpea yield responses to biochars(BCs) made from different feedstocks, baby corn peel biochar(BC1), branches of mango tree biochar(BC2), and rice husk biochar(BC3), applied in combination with nitrogen-phosphorus-potassium(NPK) fertilizers.The experiment was conducted in a greenhouse, using an acid sandy soil(Arenosol) that was submitted for 70 d to the following eight treatments: i) control;ii) full dose of NPK(a commercial compound fertilizer(12-24-12 of N-P2O5-K2O)+ urea(46% N));iii) BC1+ half dose of NPK;iv) BC1 + full dose of NPK;v) BC2 + half dose of NPK;vi) BC2 + full dose of NPK;vii) BC3 + half dose of NPK;and viii) BC3 + full dose of NPK. All biochars were applied at a rate of 0.9%(weight/weight), and each type of biochar was combined with half and full doses of NPK fertilizers. Soil pH increased significantly(P < 0.05) in treatments with BC1 and BC2,while cation exchange capacity(CEC) and available P were higher in the treatments with BC1;BC1 and BC2 also induced higher activity of enzymes related to the P cycle and higher cowpea yield. Similar soil properties and cowpea yield parameters were obtained with the full and half doses of NPK fertilizers for each type of biochar used. In conclusion, biochars in the combination with NPK fertilizers improved soil chemistry and enzymatic activities, allowing reduced fertilizer application and food production costs in the acid soil studied. | Rogerio Borguete Alves RAFAEL Maria Luisa FERNANDEZ-MARCOS Stefania COCCO Maria Letizia RUELLO Flavio FORNASIER Giuseppe CORTI | 2019 | Pedosphere2019，29，3： | 6 |
| 5 | Histone modifications:Targeting head and neck cancer stem cells显示文摘Head and neck squamous cell carcinoma(HNSCC) is the sixth most common cancer worldwide, and is responsible for a quarter of a million deaths annually. The survival rate for HNSCC patients is poor, showing only minor improvement in the last three decades. Despite new surgical techniques and chemotherapy protocols, tumor resistance to chemotherapy remains a significant challenge for HNSCC patients. Numerous mechanisms underlie chemoresistance, including genetic and epigenetic alterations in cancer cells that may be acquired during treatment and activation of mitogenic signaling pathways, such as nuclear factor kappa-light-chain-enhancer-of activated B cell, that cause reduced apoptosis. In addition to dysfunctional molecular signaling, emerging evidence reveals involvement of cancer stem cells(CSCs) in tumor development and in tumor resistance to chemotherapy and radiotherapy. These observations have sparked interest in understanding the mechanisms involved in the control of CSC function and fate. Post-translational modifications of histones dynamically influence gene expression independent of alterations to the DNA sequence. Recent findings from our group have shown that pharmacological induction of posttranslational modifications of tumor histones dynamically modulates CSC plasticity. These findings suggest that a better understanding of the biology of CSCs in response to epigenetic switches and pharmacological inhibitors of histone function may directly translate to the development of a mechanism-based strategy to disrupt CSCs. In this review, we present and discuss current knowledge on epigenetic modifications of HNSCC and CSC response to DNA methylation and histone modifications. In addition, we discuss chromatin modifications and their role in tumor resistance to therapy. | John M Le Cristiane H Squarize Rogerio M Castilho | 2014 | World Journal of Stem Cells2014，6，5： | 6 |
| 6 | 铌元素在锂离子电池中的应用显示文摘锂离子电池因其能量密度高、环境污染小等优点得到了广泛应用,但其仍然存在不容忽视的问题,电极材料结构劣化导致的电化学性能下降及热稳定性差等问题仍然比较严重,因此电极材料改性仍然是目前锂离子电池的研究重点。基于铌具有其自身独特的优势,将铌引入锂离子电池作为正极掺杂材料,可以提高电子导电性、提高稳定性、扩展Li+嵌入/脱出通道及降低阳离子混排程度;将铌引入锂离子电池作为负极活性材料,铌氧化物和铌基复合氧化物也表现出优异的电化学性能;在固态电解质中,铌既可以作为Li7La3Zr2O12的主要掺杂元素,也是Li5La3Nb2O12中的主要组成元素。本文通过对近期相关文献的梳理,对铌在锂离子电池领域中的应用进行了总结与分析,重点阐述了其掺杂作用机理及其在锂离子电池正极材料、负极材料和固态电解质中的应用。在锂离子电池正极材料中,介绍了Nb在一元材料、二元材料、三元材料以及聚阴离子材料中的研究与应用情况;在锂离子电池负极材料中,介绍了铌氧化物和铌基复合氧化物作为新型负极材料的研究与应用情况;在锂离子电池固态电解质中,介绍了铌的掺杂和应用情况。最后对Nb修饰电极材料的产业应用前景和可行性做了适当的分析。综合分析表明,铌在锂系列电池中的研究范围越来越广阔,应用不断深入,相信未来铌会在锂电池领域发挥更加重要的作用。 | 高鹏 张珊 贲留斌 赵文武 刘中柱 RIBAS Rogerio 朱永明 黄学杰 | 2020 | 储能科学与技术2020，9，5： | 3 |
| 7 | The role of natural killer cells in the uterine microenvironment during pregnancy显示文摘Pregnancy is a choreographed physiological phenomenon that involves maternal-fetal cross-talk.Elucidating the cellular and molecular mechanisms involved in this communication will allow us to develop therapies for gestational complications.Little is known about the role of natural killer(NK)cells in the uterine microenvironment.In a recent study,Fu et al.(2017)used state-of-art technologies and showed that NK cells stimulate fetal growth via growth-promoting factors. | Julia P.Andreotti Ana E.Paiva Pedro H.D.M.Prazeres Daniel A.P.Guerra Walison N.Silva Rogerio S.Vaz Akiva Mintz Alexander Birbrair | 2018 | Cellular & Molecular Immunology2018，15，11： | 3 |
| 8 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 9 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Rogerio M Mauricio Fergus L Mould Mewa S Dhanoa Emyr Owen Kulwant S Channa Michael K Theodorou | 1999 | Animal Feed Science and Technology1999，，4： | 2 |
| 10 | Region-based classification of PolSAR data using radial basis kernel functions with stochastic distances显示文摘Region-based classification of PolSAR data can be effectively performed by seeking for the assignment that minimizes a distance between prototypes and segments.Silva et al.[“Classification of segments in PolSAR imagery by minimum stochastic distances between wishart distributions.”IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing 6(3):1263–1273]used stochastic distances between complex multivariate Wishart models which,differently from other measures,are computationally tractable.In this work we assess the robustness of such approach with respect to errors in the training stage,and propose an extension that alleviates such problems.We introduce robustness in the process by incorporating a combination of radial basis kernel functions and stochastic distances with Support Vector Machines(SVM).We consider several stochastic distances between Wishart:Bhatacharyya,Kullback-Leibler,Chi-Square,Rényi,and Hellinger.We perform two case studies with PolSAR images,both simulated and from actual sensors,and different classification scenarios to compare the performance of Minimum Distance and SVM classification frameworks.With this,we model the situation of imperfect training samples.We show that SVM with the proposed kernel functions achieves better performance with respect to Minimum Distance,at the expense of more computational resources and the need of parameter tuning.Code and data are provided for reproducibility. | Rogerio G.Negri Alejandro C.Frery Wagner B.Silva Tatiana S.G.Mendes Luciano V.Dutra | 2019 | International Journal of Digital Earth2019，12，6： | 2 |
| 11 | Combined Laser and Intravitreal Triamcinolone for Proliferative Diabetic Retinopathy and Macular Edema: One-year Results of a Randomized Clinical Trial显示文摘 | Otacilio O. Maia Beatriz S. Takahashi Rogerio A. Costa Ingrid U. Scott Walter Y. Takahashi | 2009 | American Journal of Ophthalmology2009，，2： | 2 |
| 12 | Modern surgical strategies for perianal Crohn's disease显示文摘One of the most challenging phenotypes of Crohn’s disease is perianal fistulizing disease(PFCD).It occurs in up to 50%of the patients who also have symptoms in other parts of the gastrointestinal tract,and in 5%of the cases it occurs as the first manifestation.It is associated with severe symptoms,such as pain,fecal incontinence,and a significant reduction in quality of life.The presence of perianal disease in conjunction with Crohn’s disease portends a significantly worse disease course.These patients require close monitoring to identify those at risk of worsening disease,suboptimal biological drug levels,and signs of developing neoplasm.The last 2 decades have seen significant advancements in the management of PFCD.More recently,newer biologics,cell-based therapies,and novel surgical techniques have been introduced in the hope of improved outcomes.However,in refractory cases,many patients face the decision of having a stoma made and/or a proctectomy performed.In this review,we describe modern surgical management and the most recent advances in the management of complex PFCD,which will likely impact clinical practice. | Gilmara Pandolfo Zabot Ornella Cassol Rogerio Saad-Hossne Willem Bemelman | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 13 | Lead Recovery from a Typical Brazilian Sludge of Exhausted Lead-acid Batteries Using an Electro-hydrometallurgical Process显示文摘 | Luiz C Ferracin Abel E Chacon-Sanhueza Rogerio A | 2002 | Hydrometallurgy2002，65，42： | 1 |
| 14 | Paclitaxelloaded plga nanoparticles : preparation, physicochemical characterization and in vitro anti-tumoral activity显示文摘 | Cristina Fonseca Sergio Simoes Rogerio Gaspar | 2002 | J controlled Release2002，83，： | 1 |
| 15 | A beam hardening correction for X-ray microtomography显示文摘 | Rogerio Ferreira de Paiva | 1998 | NDT&E International1998，31，1： | 1 |
| 16 | A beam hardening correction for X-ray microtomography显示文摘 | Paiva Rogerio Ferreira de Lynch John Rosenberg Elisabeth | 1998 | NDT & E International1998，31，1： | 1 |
| 17 | Innovation networks:From technological development to business model recon?guration显示文摘 | Rogerio C.C Fabio M.G Gilnei L.M | | 0，，： | 1 |
| 18 | Long-range correlations and nonstationarity in the Brazilian stock market显示文摘 | Rogerio L Costa Vasconcelos G L | 2003 | Physica A2003，，329： | 1 |
| 19 | Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma显示文摘 | Rogerio A P Kanashiro A Fontanari C | 2007 | Inflammation Res2007，56，10： | 1 |
| 20 | Impro- ving power system dynamic behavior through doubly fed induction machines controlled by static converter using fuzzy control 显示文摘 | G De Almeida Rogerio J A Pecas Lopes J A L Barreiros | 2004 | IEEE Transaction on Power System November2004，19，4： | 1 |
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