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| 1 | Preliminary engineering application of microseismic monitoring technique to rockburst prediction in tunneling of Jinping Ⅱ project显示文摘Monitoring and prediction of rockburst remain to be worldwide challenges in geotechnical engineering.In hydropower,transportation and other engineering fields in China,more deep,long and large tunnels have been under construction in recent years and underground caverns are more evidently featured by 'long,large,deep and in group',which bring in many problems associated with rock mechanics problems at great depth,especially rockburst.Rockbursts lead to damages to not only underground structures and equipments but also personnel safety.It has been a major technical bottleneck in future deep underground engineering in China.In this paper,compared with earthquake prediction,the feasibility in principle of monitoring and prediction of rockbursts is discussed,considering the source zones,development cycle and scale.The authors think the feasibility of rockburst prediction can be understood in three aspects:(1) the heterogeneity of rock is the main reason for the existence of rockburst precursors;(2) deformation localization is the intrinsic cause of rockburst;and(3) the interaction between target rock mass and its surrounding rock mass is the external cause of rockburst.As an engineering practice,the application of microseismic monitoring techniques during tunnel construction of Jinping II Hydropower Station was reported.It is found that precursory microcracking exists prior to most rockbursts,which could be captured by the microseismic monitoring system.The stress concentration is evident near structural discontinuities(such as faults or joints),which shall be the focus of rockburst monitoring.It is concluded that,by integrating the microseismic monitoring and the rock failure process simulation,the feasibility of rockburst prediction is expected to be enhanced. | Chun'an Tang Jimin Wang Jingjian Zhang | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，3： | 32 |
| 2 | The efficacy and safety of weekly 35-mg risedronate dosing regimen for Chinese postmenopausal women with osteoporosis or osteopenia: 1-year data显示文摘目的: 当每周,每天管理了时,口头的 risedronate 在绝经后的骨质疏松症的处理是有效的。在这 1 年,使随机化,双窗帘,我们比较了的 multicenter 学习在有骨质疏松症或 osteopenia 的中国绝经后的女人的处理的每周的 35-mg 和每日的 5-mg risedronate dosing 政体。 | Jie-mei GU Li WANG Hua LIN De-cai CHEN Hai TANG Xiao-lan JIN Wei-bo XIA Yun-qiu HU Wen-zhen FU Jin-wei HE Hao ZHANG Chun WANG Hua YUE Wei-wei HU Yu-juan LIU Zhen-lin ZHANG | 2015 | Acta Pharmacologica Sinica2015，36，7： | 19 |
| 3 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 4 | Applications of rock failure process analysis (RFPA) method显示文摘Brittle failure of rocks is a classical rock mechanical problem.Rock failure not only involves initiation and propagation of single crack,but also is associated with initiation,propagation and coalescence of many cracks.The rock failure process analysis(RFPA)tool has been proposed since 1995.The heterogeneity of rocks at a mesoscopic level is considered by assuming that the material properties follow the Weibull distribution.Elastic damage mechanics is used for describing the constitutive law of the meso-level element.The finite element method(FEM)is employed as the basic stress analysis tool.The maximum tensile strain criterion and the Mohr-Coulomb criterion are utilized as the damage threshold.In order to solve the stability problem related to rock engineering structures,fundamental principles of strength reduction method(SRM)and gravity increase method(GIM)are integrated into the RFPA.And the acoustic emission(AE)event rate is employed as the criterion for rock engineering failure.The prominent feature of the RFPA-SRM and RFPA-GIM for stability analysis of rock engineering is that the factor of safety can be obtained without any presumption for the shape and location of the failure surface.In this paper,several geotechnical engineering applications that use the RFPA method to analyze their stability are presented to provide some references for relevant researches.The principles of the RFPA method in engineering are introduced firstly,and then the stability analysis of tunnel,slope and dam is focused on.The results indicate that the RFPA method is capable of capturing the mechanism of rock engineering stability and has the potential for application in a larger range of geo-engineering. | Chun'an Tang Shibin Tang | 2011 | Journal of Rock Mechanics and Geotechnical Engineering2011，3，4： | 14 |
| 5 | Iron-doped nickel disulfide nanoarray: A highly efficient and stable electrocatalyst for water splitting显示文摘特别地为阳极的氧进化反应(OER ) ,发展中的有效切开水的 electrocatalysts 是在精力变换技术的重要挑战。在这研究,我们经由它的 nickel-iron-layered 的 sulfidation 在 Ti 网孔(Fe 0.1-NiS2 NA/Ti ) 上报导做铁的镍二硫化物 nanoarray 的发展两倍氢氧化物先锋(NiFe-LDH NA/Ti ) 。作为三维的 OER 阳极, Fe 0.1-NiS2 NA/Ti 在 1.0 M KOH 展出显著活动和稳定性,与完成 100 mAlecular 解吸附作用的 231 mV 的低过电位的要求。温度的功能在 36 和 44 点显示出解吸附作用山峰的试验性地测量的微分工作功能? | Na Yang Chun Tang Kunyang Wang Gu Du Abdullah M. Asiri Xuping Sun | 2016 | Nano Research2016，9，11： | 11 |
| 6 | Solution structure of the RNA recognition domain of METTL3-METTL14 N^6-methyladenosine methyltransferase显示文摘N^6-methyladenosine(m6A),a ubiquitous RNA modification,is installed by METTL3-METTL14 complex.The structure of the heterodimeric complex between the methyltransferase domains(MTDs)of METTL3 and METTL14 has been previously determined.However,the MTDs alone possess no enzymatic activity.Here we present the solution structure for the zinc finger domain(ZFD)of METTL3,the inclusion of which fulfills the methyltransferase activity of METTL3-METTL14.We show that the ZFD specifically binds to an RNA containing 5'-GGACU-3'consensus sequence,but does not to one without.The ZFD thus serves as the target recognition domain,a structural feature previously shown for DNA methyltransferases,and cooperates with the MTDs of METTL3-METTL14 for catalysis.However,the interaction between the ZFD and the specific RNA is extremely weak,with the binding affinity at several hundred micromolar under physiological conditions.The ZFD contains two CCCH-type zinc fingers connected by an anti-parallel P-sheet.Mutational analysis and NMR titrations have mapped the functional interface to a contiguous surface.As a division of labor,the RNA-binding interface comprises basic residues from zinc finger 1 and hydrophobic residues fromβ-sheet and zinc finger 2.Further we show that the linker between the ZFD and MTD of METTL3 is flexible but partially folded,which may permit the cooperation between the two domains during catalysis.Together,the structural characterization of METTL3 ZFD paves the way to elucidate the atomic details of the entire process of RNA m6A modification. | Jinbo Huang Xu Dong Zhou Gong Ling-Yun Qin Shuai Yang Yue-Ling Zhu Xiang Wang Delin Zhang Tingting Zou Ping Yin Chun Tang | 2019 | Protein & Cell2019，10，4： | 11 |
| 7 | An efficient methodology for utilization of K-feldspar and phosphogypsum with reduced energy consumption and CO2 emissions显示文摘The issues of reducing CO_2 emissions, sustainably utilizing natural mineral resources, and dealing with industrial waste offer challenges for sustainable development in energy and the environment. We propose an efficient methodology via the co-reaction of K-feldspar and phosphogypsum for the extraction of soluble potassium salts and recovery of SO_2 with reduced CO_2 emission and energy consumption. The results of characterization and reactivity evaluation indicated that the partial melting of K-feldspar and phosphogypsum in the hightemperature co-reaction significantly facilitated the reduction of phosphogypsum to SO_2 and the exchange of K^+(K-feldspar) with Ca^(2+)(CaSO_4 in phosphogypsum). The reaction parameters were systematically investigated with the highest sulfur recovery ratio of ~ 60% and K extraction ratio of ~ 87.7%. This novel methodology possesses an energy consumption reduction of ~ 28% and CO_2 emission reduction of ~ 55% comparing with the present typical commercial technologies for utilization of K-feldspar and the treatment of phosphogypsum. | Zhixi Gan Zheng Cui Hairong Yue Siyang Tang Changjun Liu Chun Li Bin Liang Heping Xie | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 11 |
| 8 | Challenges and recent progress in thermal management with heat pipes for lithium-ion power batteries in electric vehicles显示文摘Electric vehicles(EVs)are globally undergoing rapid developments,and have great potentials to replace the traditional vehicles based on fossil fuels.Power-type lithium-ion batteries(LIBs)have been widely used for EVs,owing to high power densities,good charge/discharge stability,and long cycle life.The driving ranges and acceleration performances are gaining increasing concerns from customers,which depend highly on the power level of LIBs.With the increase in power outputs,rising heat generation significantly affects the battery performances,and in particular operation safety.Meanwhile,the cold-start performance is still an intractable problem under extreme conditions.These challenges put forward higher requirements for a dedicated battery thermal management system(BTMS).Compared to traditional BTMSs in EVs,the heat pipe-based BTMS has great application prospects owing to its compact structure,flexibility,low cost,and especially high thermal conductivity.Encompassing this topic,this review first introduces heat generation phenomena and temperature characteristics of LIBs.Multiple abuse conditions and thermal runaway issues are described afterward.Typical cooling and preheating methods for designing a BTMS are also discussed.More emphasis on this review is put on the use of various heat pipes for BTMSs to enhance the thermal performances of LIBs.For lack of wide application in actual EVs,more efforts should be made to extend the use of heat pipes for constructing an energy-efficient,cost-effective,and reliable BTMS to improve the performances and safety of EVs. | HUANG Yao TANG Yong YUAN Wei FANG GuoYun YANG Yang ZHANG XiaoQing WU YaoPeng YUAN YuHang WANG Chun LI JinGuang | 2021 | Science China(Technological Sciences)2021，64，5： | 10 |
| 9 | Slope spectrum variation in a simulated loess watershed显示文摘在黄土材料和消除适当地代表真黄土表面的地方,一个模仿的黄土分水岭被采用与黄土分水岭进化在斜坡光谱调查变化。模仿的黄土分水岭的进化被人工的降雨的 exogenetic 力量驾驶。为三个月的一个时期,有不同紧张和持续时间的二十个人工的降雨事件被执行。在这个过程,九个 DEM 数据设定,有 10 公里格子分辨率的各个,被靠近范围的摄影测量学的方法建立。斜坡系列然后从这些 DEM 被提取。小心地设计的量的分析的随后的系列显示了在斜坡光谱和模仿的黄土分水岭的进化之间的一种强壮的关系。斜坡光谱的量的索引变化了定期跟随模仿的黄土分水岭的进化。吝啬的斜坡,斜坡光谱信息熵(H),地面驱动力( T d ),平均数补丁区域( AREA_MN ),传染索引( CONTAG ),和补丁结合索引(结合)不停地增加跟随模仿的分水岭的进化,当时偏斜度(S),周界区域分数维的尺寸( PAFRAC ),和散布和并排索引( IJI )代表了一个相反的趋势。所有这些索引在早、活跃的发展时期活跃地变化了,但是慢慢地在稳定的发展时期。这些试验性的结果显示斜坡系列的时间系列能有效地描绘模仿的黄土分水岭的斜坡分发,因此为为黄土地形建模介绍一个潜在的方法。 | Fayuan LI Guoan TANG Chun WANG Lingzhou CUI Rui ZHU | 2016 | Frontiers of Earth Science2016，10，2： | 9 |
| 10 | Recent progress in plant-derived hard carbon anode materials for sodium-ion batteries:a review显示文摘Sodium-ion batteries(SIBs)have been considered as a promising alternative to the commercialized lithium ion batteries(LIBs)in large-scale energy storage field for its rich reserve in the earth.Hard carbon has been expected to the first commercial anode material for SIBs.Among various of hard carbon materials,plant-derived carbon is prominent because of abundant source,low cost and excellent electrochemical performance.This review focuses on the recent progress in the development of plantderived hard carbon anodes for SIBs.We summarized the microstructure and electrochemical performance of hard carbon materials pyrolyzed from different parts of plants at different temperatures.It aims to present a full scope of plant-derived hard carbon anode materials and provide indepth understanding and guideline for the design of highperformance hard carbon for sodium ion anodes. | Peng Yu Wei Tang Fang-Fang Wu Chun Zhang Hua-Yun Luo Hui Liu Zhi-Guo Wang | 2020 | Rare Metals2020，39，9： | 9 |
| 11 | Autophagy Accompanied with Bisdemethoxycurcumin-induced Apoptosis in Non-small Cell Lung Cancer Cells显示文摘Objective To investigate the effects of bisdemethoxycurcumin(BDMC) on non-small cell lung cancer(NSCLC) cell line, A549, and the highly metastatic lung cancer 95 D cells. Methods CCK-8 assay was used to assess the effect of BDMC on cytotoxicity. Flow cytometry was used to evaluate apoptosis. Western blot analysis, electron microscopy, and quantification of GFP-LC3 punctuates were used to test the effect of BDMC on autophagy and apoptosis of lung cancer cells. Results BDMC inhibited the viability of NSCLC cells, but had no cytotoxic effects on lung small airway epithelial cells(SAECs). The apoptotic cell death induced by BDMC was accompanied with the induction of autophagy in NSCLC cells. Blockage of autophagy by the autophagy inhibitor 3-methyladenine(3-MA) repressed the growth inhibitory effects and induction of apoptosis by BDMC. In addition, BDMC treatment significantly decreased smoothened(SMO) and the transcription factor glioma-associated oncogene 1(Gli1) expression. Furthermore, depletion of Gli1 by si RNA and cyclopamine(a specific SMO inhibitor) induced autophagy. Conclusion Aberrant activation of Hedgehog(Hh) signaling has been implicated in several human cancers, including lung cancers. The present findings provide direct evidence that BDMC-induced autophagy plays a pro-death role in NSCLC, in part, by inhibiting Hedgehog signaling. | XU Jin Hong YANG He Ping ZHOU Xiang Dong WANG Hai Jing GONG Liang TANG Chun Lan | 2015 | Biomedical and Environmental Sciences2015，28，2： | 9 |
| 12 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 13 | ZD 7288,an HCN channel blocker,attenuates chronic visceral pain in irritable bowel syndrome-like rats显示文摘AIM:To investigate the effects of ZD 7288,a hyperpolarization-activated cyclic nucleotide-gated(HCN)channel blocker,on rats with chronic visceral pain.METHODS:Rats with visceral hypersensitivity were generated using neonatal colon irritation during postnatal days 8-15 as described previously.Visceral hypersensitivity was evaluated using electromyographic(EMG)responses of abdominal external oblique muscles to 20-80 mmHg colorectal distentions(CRD).Abdominal withdrawal reflex(AWR)scores and pain thresholds were also detected in adult rats.Different doses of ZD7288(25,50,and 100 nmol/L)were intrathecally administered in rats to study the role of spinal HCN channel in chronic visceral hypersensitivity.RESULTS:EMG responses to 20-80 mmHg CRD and AWR scores under 20-60 mmHg CRD significantly increased in rats with visceral hypersensitivity compared to control rats(P<0.05).The pain threshold in rats with visceral hypersensitivity significantly decreased compared to control rats(P<0.05).Treatment with50-100 nmol/L ZD 7288 significantly inhibited EMG responses(16%-62%,80-20 mmHg CRD,P<0.05)and AWR scores(24%-37%,40-20 mmHg CRD,P<0.05;12%-61%,80-20 mmHg CRD,P<0.05,respectively),and significantly increased pain thresholds(32%-77%,P<0.05).CONCLUSION:Spinal HCN channels may play an important role in chronic visceral hypersensitivity. | Yu Chen Chun Lin Ying Tang Ai-Qin Chen Cui-Ying Liu Da-Li Lu | 2014 | World Journal of Gastroenterology2014，20，8： | 7 |
| 14 | Stand establishment,root development and yield of winter wheat as affected by tillage and straw mulch in the water deficit hilly region of southwestern China显示文摘Good crop stand establishment and root system development are essential for optimum grain yield of dryland wheat(Triticum aestivum L.). At present, little is known about the effect of tillage and straw mulch on the root system of wheat under dryland areas in southwestern China. The aim of this study was to evaluate the effect of three tillage treatments(no-till, NT; rotary till, RT; conventional till, CT) and two crop residue management practices(straw mulch, ML; non-straw mulch, NML) on stand establishment, root growth and grain yield of wheat. NT resulted in lower soil cover thickness for the wheat seed, higher number of uncovered seeds, lower percentage of seedling-less ridges and lower tiller density compared to RT and CT; ML resulted in higher tiller density compared to NML. Straw mulching resulted in more soil water content and root length density(RLD) at most of the growth stages and soil depths. The maximum RLD, root surface area density and root dry matter density were obtained under NT. In the topmost 10 cm soil layer, higher RLD values were found under NT than those under RT and CT. There were no significant differences in the yield or yield components of wheat among the tillage treatments in 2011–2012, but NT resulted in a significant higher yield compared to RT and CT in 2012–2013. Grain yield was significantly higher in ML compared to in NML. A strong relationship was observed between the water-use efficiency and the grain yield. Both NT and ML proved beneficial for wheat in term of maintaining higher tiller density, better soil water status and root growth, leading to a higher grain yield and enhanced water-use efficiency, especially in a low rainfall year. | LI Chao-su LI Jin-gang TANG Yong-lu WU Xiao-li WU Chun HUANG Gang ZENG Hui | 2016 | Journal of Integrative Agriculture2016，15，7： | 7 |
| 15 | Establishment and application of distant hybridization technology in fish显示文摘Hybridization is widely used. However, for a long time, systematic theories and technologies related to hybridization in fish have been lacking. In this study, through long-term systematic research, we investigated and obtained the main rules regarding inheritance and reproduction related to fish distant hybridization. Furthermore, we established one-step and multistep breeding technologies that were suitable for interspecific hybridization and intraspecific hybridization. Simultaneously, we used these two breeding technologies to produce a batch of diploid fish lineages and tetraploid fish lineages and improved fishes. In addition, we widely discuss the methods, technologies and results of hybridization breeding, referring to the domestic and foreign literature on fish hybridization. We hope that this paper will be beneficial for the research and application of fish hybrid breeding. | Shi Wang Chenchen Tang Min Tao Qinbo Qin Chun Zhang Kaikun Luo Rurong Zhao Jing Wang Li Ren Jun Xiao Fangzhou Hu Rong Zhou Wei Duan Shaojun Liu | 2019 | Science China(Life Sciences)2019，62，1： | 6 |
| 16 | Signaling pathways of chronic kidney diseases,implications for therapeutics显示文摘Chronic kidney disease(CKD)is a chronic renal dysfunction syndrome that is characterized by nephron loss,inflammation,myofibroblasts activation,and extracellular matrix(ECM)deposition.Lipotoxicity and oxidative stress are the driving force for the loss of nephron including tubules,glomerulus,and endothelium.NLRP3 inflammasome signaling,MAPK signaling,PI3K/Akt signaling,and RAAS signaling involves in lipotoxicity.The upregulated Nox expression and the decreased Nrf2 expression result in oxidative stress directly.The injured renal resident cells release proinflammatory cytokines and chemokines to recruit immune cells such as macrophages from bone marrow.NF-κB signaling,NLRP3 inflammasome signaling,JAK-STAT signaling,Toll-like receptor signaling,and cGAS-STING signaling are major signaling pathways that mediate inflammation in inflammatory cells including immune cells and injured renal resident cells.The inflammatory cells produce and secret a great number of profibrotic cytokines such as TGF-β1,Wnt ligands,and angiotensin II.TGF-βsignaling,Wnt signaling,RAAS signaling,and Notch signaling evoke the activation of myofibroblasts and promote the generation of ECM.The potential therapies targeted to these signaling pathways are also introduced here.In this review,we update the key signaling pathways of lipotoxicity,oxidative stress,inflammation,and myofibroblasts activation in kidneys with chronic injury,and the targeted drugs based on the latest studies.Unifying these pathways and the targeted therapies will be instrumental to advance further basic and clinical investigation in CKD. | Qian Yuan Ben Tang Chun Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 6 |
| 17 | A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples显示文摘Surface molecularly imprinted polymers(SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support.The physical and morphological characteristics of the polymers were investigated by scanning electron microscope(SEM),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),elemental analysis and nitrogen adsorption–desorption test.The obtained results showed that the SMIPs displayed great adsorption capacity(13.5 μg/mg),high recognition ability(the imprinted factor is 3.2) and good binding kinetics for ampicillin sodium.Finally,as solid phase extraction adsorbents,the SMIPs coupled with HPLC method were validated and applied for the enrichment,purification and determination of ampicillin sodium in real milk and blood samples.The averages of spiked accuracy ranged from 92.1% to 107.6%.The relative standard deviations of intra- and inter-day precisions were less than 4.6%.This study provides a new and promising method for enriching,extracting and determining ampicillin sodium in complex biological samples. | Ningli Wu Zhimin Luo Yanhui Ge Pengqi Guo Kangli Du Weili Tang Wei Du Aiguo Zeng Chun Chang Qiang Fu | 2016 | Journal of Pharmaceutical Analysis2016，6，3： | 6 |
| 18 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 19 | The Role of ROS in Hydroquinone-induced Inhibition of K562 Cell Erythroid Differentiation显示文摘The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation was investigated.After K562 cells were treated with hydroquinone for 24 h,and hemin was later added to induce erythroid differentiation for 48 h,hydroquinone inhibited hemin-induced | YU Chun Hong Suriguga LI Yang LI Yi Ran TANG Ke Ya JIANG Liang YI Zong Chun | 2014 | Biomedical and Environmental Sciences2014，27，3： | 5 |
| 20 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
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