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| 1 | Real-time in situ three-dimensional integral videography and surgical navigation using augmented reality: a pilot study显示文摘To evaluate the feasibility and accuracy of a three-dimensional augmented reality system incorporating integral videography for imaging oral and maxillofacial regions, based on preoperative computed tomography data. Three-dimensional surface models of the jawbones, based on the computed tomography data, were used to create the integral videography images of a subject's maxillofacial area. The three-dimensional augmented reality system (integral videography display, computed tomography, a position tracker and a computer) was used to generate a three-dimensional overlay that was projected on the surgical site via a half-silvered mirror. Thereafter, a feasibility study was performed on a volunteer. The accuracy of this system was verified on a solid model while simulating bone resection. Positional registration was attained by identifying and tracking the patient/surgical instrument's position. Thus, integral videography images of jawbones, teeth and the surgical tool were superimposed in the correct position. Stereoscopic images viewed from various angles were accurately displayed. Change in the viewing angle did not negatively affect the surgeon's ability to simultaneously observe the three-dimensional images and the patient, without special glasses. The difference in three-dimensional position of each measuring point on the solid model and augmented reality navigation was almost negligible (<1 mm); this indicates that the system was highly accurate. This augmented reality system was highly accurate and effective for surgical navigation and for overlaying a three-dimensional computed tomography image on a patient's surgical area, enabling the surgeon to understand the positional relationship between the preoperative image and the actual surgical site, with the naked eye. | Hideyuki Suenaga Huy Hoang Tran Hongen Liao Ken Masamune Takeyoshi Dohi Kazuto Hoshi Yoshiyuki Mori Tsuyoshi Takato | 2013 | International Journal of Oral Science2013，5，2： | 11 |
| 2 | Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model显示文摘AIM: To evaluate the effect of ANP on warm I/R injury in a porcine THVE model. METHODS: Miniature pigs (mini-pigs) weighing 16-24 kg were observed for 120 min after reperfusion following 120 min of THVE. The animals were divided into two groups. ANP (0.1 μg/kg per min) was administered to the ANP group (n = 7), and vehicle was administered to the control group (n = 7). Either vehicle or ANP was intravenously administered from 30 min before the THVE to the end of the experiment. Arterial blood was collected to measure AST, LDH, and TNF-α. Hepatic tissue blood ? ow (HTBF) was also measured. Liver specimens were harvested for p38 MAPK analysis and histological study. Those results were compared between the two groups. RESULTS: The AST and LDH levels were lower in the ANP group than in the control group; the AST levels were signifi cantly different between the two groups (60 min: 568.7 ± 113.3 vs 321.6 ± 60.1, P = 0.038 < 0.05, 120 min: 673.6 ± 148.2 vs 281.1 ± 44.8, P = 0.004 < 0.01). No signifi cant difference was observed in the TNF-α levels between the two groups. HTBF was higher in the ANP group, but the difference was not signif icant. A signifi cantly higher level of phosphorylated p38 MAPK was observed in the ANP group compared to the controlgroup (0 min: 2.92 ± 1.1 vs 6.38 ± 1.1, P = 0.011 < 0.05).Histological tissue damage was milder in the ANP group than in the control group. CONCLUSION: Our results show that ANP has a protective role in I/R injury with p38 MAPK activation in a porcine THVE model. | Katsumi Kobayashi Kiyohiro Oshima Masato Muraoka Takahiko Akao Osamu Totsuka Hisashi Shimizu Hiroaki Sato Kazumi Tanaka Kenjiro Konno Koshi Matsumoto Izumi Takeyoshi | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 3 | Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer显示文摘AIM: To investigate the clinical significance of BMP and activin membrane-bound inhibitor (BAMBI) which is a pseudoreceptor of transforming growth factor-beta (TGF-β) type Ⅰreceptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers (CRCs). We studied BAMBI expression in CRCs. METHODS: We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β-catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison control.RESULTS: Immunohistochemical analysis revealed that BAMBI expression was observed in 148 (80.8%), and strong BAMBI expression was observed in 46% of the CRCs. Strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis (TNM) stage (P < 0.05). Clear associations were found between BAMBI and β-catenin (P = 0.035) and p53 (P = 0.049) expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% (P = 0.037) for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox’s multivariate analysis, lymph node metastases (RR 6.685; P < 0.001) and depth of invasion (RR 14.0; P = 0.013) were signifi cant indicators for recurrence, and strong BAMBI expression (RR 2.26; P = 0.057) tended to be signifi cant. CONCLUSION: BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC. | Nozomi Togo Susumu Ohwada Shinji Sakurai Hiroyuki Toya Ichiro Sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi Sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama | 2008 | World Journal of Gastroenterology2008，14，31： | 3 |
| 4 | Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver显示文摘AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury. | Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi Izumi Takeyoshi Yukihiro Inomata Koichi Tanaka Eiji Kobayashi | 2009 | World Journal of Gastroenterology2009，15，45： | 3 |
| 5 | Plasma Brain Natriuretic Peptide Levels Increase in Proportion to the Extent of Right Ventricular Dysfunction in Pulmonary Hypertension显示文摘 | Noritoshi Nagaya Toshio Nishikimi Yoshiaki Okano Masaaki Uematsu Toru Satoh Shingo Kyotani Sachio Kuribayashi Seiki Hamada Mikio Kakishita Norifumi Nakanishi Makoto Takamiya Takeyoshi Kunieda Hisayuki Matsuo Kenji Kangawa | 1998 | Journal of the American College of Cardiology1998，，1： | 2 |
| 6 | Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury显示文摘AIM:To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX therapy)for warm hepatic ischemia-reperfusion(I/R)injury after total hepatic vascular exclusion (THVE)using a porcine model. METHODS:Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min.The animals were divided into two groups randomly:the DHP-PMX group(n=5)underwent DHP-PMX at a flow rate of 80 mL/min for 120 min(beginning 10 min before reperfusion),while the control group did not(n=6).The rate pressure product (RPP):heart rate×end-systolic arterial blood pressure, hepatic tissue blood flow(HTBF),portal vein blood flow (PVBF),and serum aspartate aminotransferase(AST) levels were compared between the two groups. RESULTS:RPP and HTBF were significantly(P< 0.05)higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion.PVBF in the DHP-PMX group was maintained at about 70%of the flow before ischemia and differed significantly(P <0.05)compared to the control group 360 min after reperfusion.The serum AST increased gradually afterreperfusion in both groups,but the AST was significantly(P<0.05)lower in the DHP-PMX group 360 min after reperfusion. CONCLUSION:DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model. | Hiroaki Sato Kiyohiro Oshima Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi | 2009 | World Journal of Gastroenterology2009，15，36： | 2 |
| 7 | Intraperitoneal Hyperthermic Perfusion Combined with Surgery Effective for Gastric Cancer Patients with Peritoneal Seeding显示文摘 | SHIGERU FUJIMOTO RAM DHOJ SHRESTHA MASASHI KOKUBUN MASAYASU OHTA MAKOTO TAKAHASHI KOKURIKI KOBAYASHI SOHZABURO KIUCHI KATSUJI OKUI TAKEYOSHI MIYOSHI NOBORU ARIMIZU HIROYOSHI TAKAMIZAWA | 1988 | Annals of Surgery1988，，1： | 2 |
| 8 | Direct hemoperfusion with a polymyxin B-immobilized cartridge in intestinal warm ischemia reperfusion显示文摘AIM: To investigate the effectiveness of direct hemo- perfusion with polymyxin B-immobilized fibers (DHP- PMX therapy) on warm ischemia-reperfusion (I/R) injury of the small intestine. METHODS: The proximal jejunum and distal ileum of mongrel dogs were resected. Warm ischemia was performed by clamping the superior mesenteric artery (SMA) and vein (SMV) for 2 h. Blood flow to the proximal small intestine was restored 1 h after reperfusion, and the distal small intestine was used as a stoma. The experiment was discontinued 6 h after reperfusion. The dogs were divided into two groups: the DHP-PMX group (n = 6, DHP-PMX was performed for 180 min; from 10 min prior to reperfusion to 170 min after reperfusion) and the control group (n = 5). The rate pressure product (RPP), SMA blood flow, mucosal tissue blood flow, and intramucosal pH (pHi) were compared between the two groups. The serum interleukin (IL)-10 levels measured 170 min after reperfusion were also compared. RESULTS: The RPP at 6 h after reperfusion was significantly higher in the PMX group than in the control group (12 174 ± 1832 mmHg/min vs 8929 ± 1797 mmHg/min, P < 0.05). The recovery rates ofthe SMA blood flow at 1 and 6 h after reperfusion were significantly better in the PMX group than in the control group (61% ± 7% vs 44% ± 4%, P < 0.05, and 59% ± 5% vs 35% ± 5%, P < 0.05, respectively). The recovery rate of the mucosal tissue blood flow and the pHi levels at 6 h after reperfusion were significantly higher in the PMX group (61% ± 8% vs 31% ± 3%, P < 0.05 and 7.91 ± 0.06 vs 7.69 ± 0.08, P < 0.05, respectively). In addition, the serum IL-10 levels just before DHP-PMX removal were significantly higher in the PMX group than in the control group (1 569 ± 253 pg/mL vs 211 ± 40 pg/mL, P < 0.05). CONCLUSION: DHP-PMX therapy reduced warm I/R injury of the small intestine. IL-10 may play a role in inhibiting I/R injury during DHP-PMX therapy. | Hiroaki Sato Kazuhisa Arakawa Katsumi Kobayashi Hodaka Yamazaki Yujin Suto Izumi Takeyoshi Kiyohiro Oshima | 2008 | World Journal of Gastroenterology2008，14，35： | 2 |
| 9 | Recrystallizationbehavior during hot rolling of 3004 aluminum alloy显示文摘 | Shigeniori A Takeyoshi D Keisuke Y | 1989 | LightMetals(in Japanese)1989，39，2： | 1 |
| 10 | An amber replication mutant of F plasmid mapped in the minimal replication region显示文摘 | Satoko Maki Minoru Kuribayashi Takeyoshi Miki Tadao Horiuchi | 1983 | MGG Molecular & General Genetics1983，，2： | 1 |
| 11 | FR167653 ameliorates ischemia-reperfusion injury of the rat liver through P38 mitogen-activated protein kinase pathway显示文摘 | Kobayashi M Takeyoshi I Yoshinari D | 2001 | Transplant Proc2001，33，12： | 1 |
| 12 | Transdemal ketoprofen mitigates the severity of postoperative sore throat显示文摘 | Masayuki O Kouichiro M Takeyoshi S | 2004 | Can J Anesth2004，45，11： | 1 |
| 13 | FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38 mitogen-activated protein kinase显示文摘 | Kawashima Y Takeyoshi I Otani Y | 2001 | J Heart Lung Transplant2001，20，5： | 1 |
| 14 | Transdemal ketoprofen mitigates the severity of postoperative sore throat 显示文摘 | Masayuki O Kouichiro M Takeyoshi S | 2004 | Can J Anesth2004，45，11： | 1 |
| 15 | FR167653 ameliorates pulmonary damage in ischemia-reperfusion injury in a canine lung transplantation mode显示文摘 | Aiba M Takeyoshi I Sunose Y | 2000 | J Heart Lung Transplant2000，19，9： | 1 |
| 16 | Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals显示文摘 | Kanji Yamasaki Masahiro Takeyoshi Yoshikuni Yakabe | 2002 | Toxicology2002，170，： | 1 |
| 17 | The effect of short-term coronary perfusion using a perfusion apparatus on canine heart transplantation from nonheart-beating donors显示文摘 | Koike N Takeyoshi I Ohki S | 2003 | J Heart Lung Transplant2003，22，7： | 1 |
| 18 | Repeated temperature modulation epitaxy for p-type doping and light-emitting diode based on ZnO 显示文摘 | Atsushi T Akira O Takeyoshi O | 2005 | Nature Materials2005，4，： | 1 |
| 19 | Effects of a p38 mitogen - activated protein kinase inhibitor as an additive to Euro - Collins solution on repeffusion injury in canine lung transplantation显示文摘 | Hashimoto N Takeyoshi I Yoshinarl D | 2002 | Transplantation2002，74，： | 1 |
| 20 | Intramucosal pH and intestinal mucosal damage in ischemia-reperfusion injury显示文摘 | Kotaro Iwanami I. Takeyoshi Susumu Ohwada Junya Kobayashi Kiyoshi Kawata Koshi Matsumoto Yasuo Morishita | 1998 | Transplant International1998，，6： | 1 |
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