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| 1 | 卵巢移行细胞癌是低分化型高级别浆液性或子宫内膜样腺癌显示文摘依据最新WHO分类,卵巢移行细胞肿瘤包括Brenner瘤(BTs)和移行细胞癌(TCC;非BTs),但对于TCC是一种明确的肿瘤实体还是高级别浆液性癌(HG—SC)的形态学亚型仍存在争议。本文的目的是通过对TCC的形态学、免疫组化和分子学特征进行分析,解决上述问题。作者共收集488例卵巢上皮性癌,根据Kobel和其同事修订的最新WHO分类重新分类。共诊断35例TCC,其中25例和6例TCCs分别混合有HG—SC和子宫内膜样腺癌成分,4例单纯性TCC。 | Takeuchi T Ohishi Y Imamura H 解建军 张仁亚 | 2013 | 临床与实验病理学杂志2013，29，10： | 11 |
| 2 | A Toll-like receptor recognizes bacterial DNA显示文摘 | Hemmi H Takeuchi O Kawai T | | 0，，： | 4 |
| 3 | Reciprocal connections between the amygdala and parabrachial nuclei:ultrastructural demonstration by degeneration and axonal transport of horseradish peroxidase in the cat 显示文摘 | Takeuchi Y McLean J H Hopkins D A | 1982 | Brain Res1982，239，： | 2 |
| 4 | Comparative effects of dietary fat types on hepatic enzyme activities related to the synthesis and oxidation of fatty acid and to lipogenesis in rats 显示文摘 | Takeuchi H Nakamoto T Mori Y | 2001 | Biosci Biotechnol Biochem2001，65，8： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide显示文摘AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins. | H Yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 7 | Nitrile hydratase of Pseudomonas chlororaphis B23: Purification and characterization 显示文摘 | Nagasawa T Nanba H Ryuno K Takeuchi K Yamada H | 1987 | Eur J Biochem1987，162，： | 1 |
| 8 | Mucosadhesive DL-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin显示文摘 | Yamamoto H Takeuchi H | 2000 | Pharm Dev Technol2000，5，1： | 1 |
| 9 | Changes in cerebral circulation and neuronal metabolism during chronic cerebral vasospasm after sub-arachnoid hemorrhage显示文摘 | Takeuchi H Tsuchida A | 2003 | International Congress Series2003，1251，： | 1 |
| 10 | Characterization of a new cobalt-containing nitrile hydratase purified from urea-induced cells of Rhodococcus rhodochrous J1显示文摘 | Nagasawa T Takeuchi K Yamada H | 1991 | Eur J Biochem1991，196，： | 1 |
| 11 | For hydro- environmental simulation of a large ungauged basin- introduction of block-wise use of TOPMODEL and Muskingum-Cunge method 显示文摘 | Takeuchi K Ao Tianqi Ishidaira H | 1999 | Hydrological Sciences Journal1999，44，4： | 1 |
| 12 | Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes显示文摘 | Amano S Yamagishi S Inagaki Y Nakamura K Takeuchi M Inoue H | 2005 | Microvasc Res2005，69，12： | 1 |
| 13 | Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells 显示文摘 | Kojima H Katsura E Takeuchi S | 2004 | Environ Health Perspect2004，112，5： | 1 |
| 14 | Pyrolytic carbon nanotubes from vapor-grown carbon fibers 显示文摘 | ENDO M TAKEUCHI K KROTO H | 1995 | Carbon1995，33，7： | 1 |
| 15 | Piezoelectricity of c-axis orented PbTiO3 Thin-films显示文摘 | Kushida K Takeuchi H | 1987 | Appl Phys Lett1987，50，25： | 1 |
| 16 | Phenolic compounds from Coix lachryrrtal-jobi var Ma-yuen 显示文摘 | Otsuka H Takeuchi M Inoshiri S | 1989 | Phytochemistry1989，28，： | 1 |
| 17 | A Toll like receptor recognizes bacterial DNA显示文摘 | HEMMI H TAKEUCHI 0 KAWAI T | 2000 | Nature2000，408，： | 1 |
| 18 | Carcinoma of the esophagus: CT vs MR imaging in determining respectability显示文摘 | Takashima S Takeuchi N Shiozaki H | 1991 | A JR Am J Roentgenol1991，156，2： | 1 |
| 19 | Laparoscopy-assisted proximal gastrectomy with sentinel node mapping for early gastric cancer显示文摘 | Takeuchi H | 2011 | World J Surg2011，35，11： | 1 |
| 20 | Design and evaluation ofnovel pH-sensitive chitosan nanoparticles for oral insulin delivery显示文摘 | Makhlof A Tozuka YC Takeuchi H | 2011 | European Journal of Pharmaceutical Sciences2011，42，5： | 1 |
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