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| 1 | 市区软土地层地下工程施工新技术显示文摘为了使现代城市更有效率,具有更多功能,全球各大城市愈发关注地下空间的利用问题。然而,由于在大城市很多地下建筑物(如重要市政管线)已经开发,要开发新的地下空间,就要求更好更有效地利用浅层和深层的地下空间。因此,在尽量不影响地下水自然环境及邻近的地下或地上建筑物的前提下,开发适用于深埋和/或大断面建筑物的施工技术显得尤为重要。此外,由于多数亚洲国家大城市的地层由软弱沉积物构成,如黏土、淤泥、砂、砾石层等,且地下水位高;所以,有关现场勘察、设计、安全管理和环境保护监控、地下水处理、土体改良等的新技术都是必需的。根据这些需求,总结了在日本开发的新技术,包括现场勘察与监控技术、隧道及地下工程施工技术、土体改良技术、地下水处理技术与地下径流保持技术等。希望这些技术能够满足各大城市经济高效、环保地开发地下空间的需求。这些新技术不仅对发达国家大城市的地下空开发有用,而且对发展中城市的地下空间开发同样有用。 | Tadashi Hashimoto Yujian LIU | 2012 | 隧道建设2012，32，3： | 6 |
| 2 | Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasome Inhibition In Vitro显示文摘 | Yan Yan Minao Furumura Takako Gouya Atsufumi Iwanaga Kwesi Teye Sanae Numata Tadashi Karashima Xiao-Guang Li Takashi Hashimoto | 2015 | Chinese Medical Journal2015，，16： | 6 |
| 3 | New Method for Specifying Color-Rendering Properties of Light Sources Based on Feeling of Contrast显示文摘 | KENJIRO Hashimoto TADASHI Yano | 2006 | Color Research and Application2006，，11： | 1 |
| 4 | Etiology of community - acquired pneumonia in hospitalized patients 显示文摘 | Torn Hashimoto Machiko Arita | 1998 | Chest1998，114，6： | 1 |
| 5 | Annular pancreas detected in adults, diagnosed by endoscopic retrograde cholangiopancreatography: Report of four cases显示文摘 | Yoshikuni Yogi Tadashi Shibue Shuji Hashimoto | 1987 | Gastroenterologia Japonica1987，，1： | 1 |
| 6 | Annular pancreas detected in adults, diagnosed by endoscopic retrograde cholangiopancreatography: Report of four cases显示文摘 | Yoshikuni Yogi M.D. Tadashi Shibue M.D. Shuji Hashimoto M.D | 1987 | Gastroenterologia Japonica1987，，1： | 1 |
| 7 | New method for specifying color-rendering properties of light sources based on feeling of contrast 显示文摘 | Hashimoto Kenjiro Tadashi Yano Masanori Shimizu | 2007 | Color Research & Application2007，32，5： | 1 |
| 8 | Preference index for Japanese complexion color under illumination 显示文摘 | Yano Tadashi Hashimoto Kenjiro | 1998 | Journal of light and visual environment1998，22，2： | 1 |
| 9 | Expressions of Insulin-Like Growth Factor Receptor-1 and Insulin-Like Growth Factor Binding Protein 3 in Advanced Non–Small-Cell Lung Cancer显示文摘 | Young Hak Kim Shinji Sumiyoshi Seiji Hashimoto Katsuhiro Masago Yosuke Togashi Yuichi Sakamori Chiyuki Okuda Tadashi Mio Michiaki Mishima | 2012 | Clinical Lung Cancer2012，，： | 1 |
| 10 | Phagocytosis of bacterial magnetite by leucocytes显示文摘 | Tadashi Matsunaga Kohji Hashimoto Noriyuki Nakamura Kayoko Nakamura Shozo Hashimoto | 1989 | Applied Microbiology and Biotechnology1989，，4： | 1 |
| 11 | Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system显示文摘 | Hongyan Dong Nobuaki Toyoda Hiroyuki Yoneyama Makoto Kurachi Tadashi Kasahara Yoshiro Kobayashi Hidekuni Inadera Shin-ichi Hashimoto Kouji Matsushima | 2002 | Biochemical and Biophysical Research Communications2002，，5： | 1 |
| 12 | Synthesis and characterization of Linde A zeolite coated with a layered double hydroxide 显示文摘 | Hirohisa Yamada Yujiro Watanabe Tadashi Hashimoto | 2014 | Journal of the European Ceramic Society2014，26，： | 1 |
| 13 | A practical method for epoxidation of terminal olefins with 30%hydrogen peroxide under halide-free conditions显示文摘 | Kazuhiko Sato M A Masami Ogawa Tadashi Hashimoto | 1996 | J Org Chem1996，61，23： | 1 |
| 14 | Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival显示文摘BACKGROUND Despite the popularity of immune checkpoint inhibitors(ICIs)in the treatment of advanced cancer,patients often develop gastrointestinal(GI)and non-GI immune-related adverse events(irAEs).The clinical characteristics and survival outcomes of GI-irAEs have not been fully elucidated in previous reports.This necessitates the evaluation of the impact of GI-irAEs on patients receiving ICI treatment.AIM To evaluate the clinical characteristics of GI-irAEs and their impact on survival in patients treated with ICIs.METHODS In this single-center,retrospective,observational study,we reviewed the records of 661 patients who received ICIs for various cancers at Nagoya University Hospital from September 2014 to August 2020.We analyzed the clinical characteristics of patients who received ICI treatment.We also evaluated the correlation between GI-irAE development and prognosis in non-small cell lung cancer(LC)and malignant melanoma(MM).Kaplan-Meier analysis was used to compare the median overall survival(OS).Multivariate Cox proportional hazards models were used to identify prognostic factors.A P value<0.05 was considered statistically significant.RESULTS GI-irAEs occurred in 34 of 605 patients(5.6%)treated with an anti-programmed cell death-1/programmed death-ligand 1(anti-PD-1/PD-L1)antibody alone and in nine of 56 patients(16.1%)treated with an anti-cytotoxic T-lymphocyte antigen 4(CTLA-4)antibody alone or a combination of anti-PD-1 and anti-CTLA-4 antibodies.The cumulative incidence and median daily diarrhea frequency were significantly higher in patients receiving anti-CTLA-4 antibodies(P<0.05).In 130 patients with MM,OS was significantly prolonged in the group that continued ICI treatment despite the development of GI-irAEs compared to the group that did not experience GI-irAEs(P=0.035).In contrast,in 209 patients with non-small cell LC,there was no significant difference in OS between the groups.The multivariate analyses showed that a performance status of 2-3(hazard ratio:2.406;95%confidence interval:1.125–5.147;P=0.024)was an independent predictive factor for OS in patients with MM.CONCLUSION Patients receiving anti-CTLA-4 antibodies develop GI-irAEs more frequently and with higher severity than those receiving anti-PD-1/PD-L1 antibodies.Continuing ICI treatment in patients with MM with GI-irAEs have better OS. | Kentaro Yamada Tsunaki Sawada Masanao Nakamura Takeshi Yamamura Keiko Maeda Eri Ishikawa Tadashi Iida Yasuyuki Mizutani Naomi Kakushima Takuya Ishikawa Kazuhiro Furukawa Eizaburo Ohno Takashi Honda Hiroki Kawashima Masatoshi Ishigami Satoshi Furune Tetsunari Hase Kenji Yokota Osamu Maeda Naozumi Hashimoto Masashi Akiyama Yuichi Ando Mitsuhiro Fujishiro | 2021 | World Journal of Gastroenterology2021，27，41： | 0 |
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