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| 1 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 2 | Antibiotics and probiotics in chronic pouchitis:A comparative proteomic approach显示文摘AIM:To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment,using a comparative proteomic approach. METHODS:Two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ ionization-time of flight mass spectrometry were used to characterize the changes related to antibiotic therapy in the protein expression profiles of biopsy samples from patients with chronic refractory pouchitis.The same proteomic approach was applied to identify differentially expressed proteins in the non-inflamed pouch before and after probiotic administration. RESULTS:In the first set of 2D gels,26 different proteins with at least 2-fold changes in their expression levels between the pouchitis condition and antibiotic-induced remission were identified.In the second set of analysis,the comparison between mucosal biopsy proteomes in the normal and probiotic-treated pouch resulted in 17 significantly differently expressed proteins.Of these,8 exhibited the same pattern of deregulation as in the pouchitis/pouch remission group. CONCLUSION:For the first time,2D protein maps of mucosal biopsies from patients with ileal pouch-anal anastomosis were provided,and differentially expressed proteins following antibiotic/probiotic treatment were identified. | Silvia Turroni Beatrice Vitali Marco Candela Paolo Gionchetti Fernando Rizzello Massimo Campieri Patrizia Brigidi | 2010 | World Journal of Gastroenterology2010，16，1： | 3 |
| 3 | Ageing and gut microbes: Perspectives for health maintenance and longevity显示文摘 | Elena Biagi Marco Candela Silvia Turroni Paolo Garagnani Claudio Franceschi Patrizia Brigidi | 2012 | Pharmacological Research2012，，： | 2 |
| 4 | Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for hostderived glycan foraging显示文摘 | TURRONI F BOTTACINI F FORONI E | | 0，，： | 1 |
| 5 | Oxalate con- sumption by laetobacilli: evaluation of oxalyl - CoA deearboxylase and formyl - CoA transferase activity in Lactobacillus acidophilus 显示文摘 | TURRONI S VITALI B BENDAZZOLI C | 2007 | J Appl Mierobiol2007，103，5： | 1 |
| 6 | Evaluation of bifidobacterial community composition in the human gut by means of a targeted amplicon sequencing (ITS) protocol 显示文摘 | Milani C Lugli GA Turroni F | 2014 | FEMS Microbial Ecol2014，90，2： | 1 |
| 7 | Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics显示文摘 | Lugli GA Milani C Turroni F | 2014 | Applied and Environmental Microbiology2014，80，20： | 1 |
| 8 | Oxalate -de- grading activity in Bifidobaeterium animalis subsp, lactis: impact of acidic conditions on the transcriptional levels of the oxalyl coenzyme A (CoA) decarboxylase and formyl -CoA transferase genes 显示文摘 | TURRONI S BENDAZZOLI C DIPALO S C | 2010 | Appl Environ Mierobiol2010，76，16： | 1 |
| 9 | Host–microbe interactions that facilitate gut colonization by commensal bifidobacteria显示文摘 | Marco Ventura Francesca Turroni Mary O’Connell Motherway John MacSharry Douwe van Sinderen | 2012 | Trends in Microbiology2012，，10： | 1 |
| 10 | Microbial diveity in the human intestine and novel insights from metagenomics显示文摘 | Ventura M Turroni F Canchaya C | | 0，，： | 1 |
| 11 | Intestinal microbiota is a plastic factor responding to environmental changes显示文摘 | Marco Candela Elena Biagi Simone Maccaferri Silvia Turroni Patrizia Brigidi | 2012 | Trends in Microbiology2012，，8： | 1 |
| 12 | Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia显示文摘Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural hibernators, highlighting an unexpected importance of the gut microbial ecosystem in hibernation and torpor. In natural hibernators, intestinal microbes adaptively reorganize their structural configuration during torpor, and maintain a mutualistic configuration regardless of long periods of fasting and cold temperatures. This allows the gut microbiome to provide the host with metabolites, which are essential to keep the host immunological and metabolic homeostasis during hibernation. The emerging role of the gut microbiota in the hibernation process suggests the importance of maintaining a mutualistic gut microbiota configuration in the application of therapeutic hypothermia as well as in the development of new strategy such as the use of synthetic torpor in humans. The possible utilization of tailored probiotics to mold the gut ecosystem during therapeutic hypothermia can also be taken into consideration as new therapeutic strategy. | Claudia Sisa Silvia Turroni Roberto Amici Patrizia Brigidi Marco Candela Matteo Cerri | 2017 | World Journal of Gastroenterology2017，23，3： | 1 |
| 13 | Teaching evidencebased practice:developing a curriculum model to foster evidence-based practice in undergraduate student nurses显示文摘 | Finotto S Carpanoni M Turroni EC | 2013 | Nurse Educ Pract2013，13，5： | 1 |
| 14 | Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective显示文摘 | Francesca Turroni Marco Ventura Ludovica F. Buttó Sabrina Duranti Paul W. O’Toole Mary O’Connell Motherway Douwe Sinderen | 2014 | Cellular and Molecular Life Sciences2014，，2： | 1 |
| 15 | Analysis of Predicted Carbohydrate Transport Systems Encoded by Bifidobacterium Bifidum PRL2010显示文摘 | TURRONI F STRATI F FORONI E | 2012 | Applied and Environmental Microbiology2012，78，14： | 1 |
| 16 | Exploring the diversity of the bifidobacterial population in the human intestinal tract显示文摘 | Turroni F Foroni E Pizzetti P | 2009 | Applied and Environmental Microbiology2009，75，6： | 1 |
| 17 | Improving fingerprint orienta- tion extraction显示文摘 | Turroni F Maltoni D Cappelli R | 2011 | IEEE Trans on Information Forensics and Se- curity2011，6，3： | 1 |
| 18 | Microbial diversity in the human intestine and novel insights from metagenomics显示文摘 | VENTURA M TURRONI F CANCHAYA C | | 0，，01： | 1 |
| 19 | Exploring the diversity of the bifidobacterial population in the human in- testinal tract显示文摘 | Turroni F Foroni E Pizzetti P | 2009 | Appl Environ Microbiol2009，75，6： | 1 |
| 20 | Effect of a new synbiotic supplement on symptoms, stool consistency, intestinal transit time and gut microbiota in patients with severe functional constipation: a pilot randomized double-blind, controlled trial显示文摘 | G. Bazzocchi T. Giovannini C. Giussani P. Brigidi S. Turroni | 2014 | Techniques in Coloproctology2014，，10： | 1 |
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