|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 《过敏性鼻炎及其对哮喘的影响(ARIA)》指南2019版过敏性鼻炎管理路径(中国版)显示文摘2018年12月3日,慢性疾病管理大会在巴黎召开,经过与会的过敏科学及气道疾病领域的专家和患者组织讨论,针对未来鼻炎和哮喘的管理,推荐采用真实世界综合管理路径评估系统,旨在实现数字化、综合化、以人为本的管理。本文是该文件的摘要版,其中也介绍了中国过敏性鼻炎和哮喘的流行状况以及《过敏性鼻炎及其对哮喘的影响》(ARIA)在中国应用的具体情况。 | Bachert C Fokkens WJ Haahtela T Hellings PH Klimek L Papadopoulos N Pham-Thi N PfaarO Valiulis A Ventura MT Onorato G Czarlewski W Bedbrook A Bousquet J 王向东(编译) 王成硕(编译) 郑铭(编译) 杜崑(编译) 张罗(编译) | 2019 | 中国耳鼻咽喉头颈外科2019，26，12： | 23 |
| 2 | 高血压患者脑小血管病变化对认知功能的影响显示文摘高血压是脑小血管病进展与认知功能障碍的主要危险因素之一。该研究旨在探讨高血压患者脑小血管病损伤变化与认知功能减退及轻度认知功能障碍的关系。该研究的数据从ISSYS队列(探讨高血压无症状性脑卒中:一个磁共振成像研究)中获得,其是一项纵向人群研究,纳入基线无痴呆及脑卒中,年龄50~70岁的高血压患者。 | Jiménez-Balado J Riba-Llena I Abril O Garde E Penalba A Ostos E Maisterra O Montaner J Noviembre M Mundet X Ventura O Pizarro J Delgado P 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，2： | 15 |
| 3 | Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease显示文摘Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in moderate to severe active Crohn’s disease and ulcerative colitis. Despite their extensive therapeutic use and the proven effectiveness, considerable clinical evidence of wide inter-individual differences in GC efficacy among patients has been reported, in particular when these agents are used in inflammatory diseases. In recent years, a detailed knowledge of the GC mechanism of action and of the genetic variants affecting GC activity at the molecular level has arisen from several studies. GCs interact with their cytoplasmic receptor, and are able to repress inflammatory gene expression through several distinct mechanisms. The glucocorticoid receptor (GR) is therefore crucial for the effects of these agents: mutations in the GR gene (NR3C1, nuclear receptor subfamily 3, group C, member 1) are the primary cause of a rare, inherited form of GC resistance; in addition, several polymorphisms of this gene have been described and associated with GC response and toxicity.However, the GR is not self-standing in the cell and the receptor-mediated functions are the result of a complex interplay of GR and many other cellular partners. The latter comprise several chaperonins of the large cooperative hetero-oligomeric complex that binds the hormonefree GR in the cytosol, and several factors involved in the transcriptional machinery and chromatin remodeling, that are critical for the hormonal control of target genes transcription in the nucleus. Furthermore, variants in the principal effectors of GCs (e.g. cytokines and their regulators) have also to be taken into account for a comprehensive evaluation of the variability in GC response. Polymorphisms in genes involved in the transport and/or metabolism of these hormones have also been suggested as other possible candidates of interest that could play a role in the observed inter-individual differences in efficacy and toxicity. The best-characterized example is the drug efflux pump P-glycoprotein, a membrane transporter that extrudes GCs from cells, thereby lowering their intracellular concentration. This protein is encoded by the ABCB1/ MDR1 gene; this gene presents different known polymorphic sites that can influence its expression and function. This editorial reviews the current knowledge on this topic and underlines the role of genetics in predicting GC clinical response. The ambitious goal of pharmacogenomic studies is to adapt therapies to a patient’s specific genetic background, thus improving on efficacy and safety rates. | Sara De Iudicibus Raffaella Franca Stefano Martelossi Alessandro Ventura Giuliana Decorti | 2011 | World Journal of Gastroenterology2011，17，9： | 14 |
| 4 | 特发性脊柱侧凸King、Lenke和PUMC临床分型的应用比较显示文摘目的比较特发性脊柱侧凸King、Lenke和PUMC分型的全面性及其对手术的指导价值。方法回顾性分析在巴塞罗那SantJoanDeDéu医院接受手术治疗的特发性脊柱侧凸患者145例的临床及影像学资料。所有病例均进行King、Lenke和PUMC分型,比较手术原则与三种分型方法的符合率及术后失代偿的发生情况。结果King分型能对全部病例中的122例进行分型,有23例无法应用King分型;而Lenke分型和PUMC分型均能对全部病例进行分型。145例患者中,手术原则符合King分型者99例(68.3%),符合Lenke分型者120例(82.8%),符合PUMC分型者107例(73.8%)。95例患者随访3~96个月,平均29.6个月。其中手术原则符合King分型、Lenke分型和PUMC分型融合范围而于术后与随访时发生冠状面躯干失平衡(失代偿)的发生率分别为26.3%(26/99)和13.2%(9/68)、30.8%(37/120)和12.5%(10/80)、14.0%(15/107)和2.7%(2/74),符合PUMC分型而发生冠状面躯干失平衡的发生率与符合King分型、Lenke分型者比较差异均有统计学意义(P<0.05)。上胸弯和主胸弯的柔韧性与胸腰弯和腰弯比较差异有统计学意义(P<0.05)。结论特发性脊柱侧凸的PUMC分型与Lenke分型比King分型更全面,PUMC分型比King分型和Lenke分型更具手术指导意义。对不同部位的脊柱侧凸采用统一的凸侧Bending位X线片上Cobb角超过25°来定义结构性侧凸并不合适。 | 邱贵兴 于斌 Norbert Ventura 仉建国 王以朋 翁习生 石志才 | 2006 | 中华骨科杂志2006，26，3： | 13 |
| 5 | Plant xylem hydraulics:What we understand,current research,and future challenges显示文摘Herein we review the current state-of-the-art of plant hydraulics in the context of plant physiology,ecology, and evolution, focusing on current and future research opportunities. We explain the physics of water transport in plants and the limits of this transport system,highlighting the relationships between xylem structure and function. We describe the great variety of techniques existing for evaluating xylem resistance to cavitation. We address several methodological issues and their connection with current debates on conduit refilling and exponentially shaped vulnerability curves. We analyze the trade-offs existing between water transport safety and efficiency. We also stress how little information is available on molecular biology of cavitation and the potential role of aquaporins in conduit refilling. Finally,we draw attention to how plant hydraulic traits can be used for modeling stomatal responses to environmental variables and climate change, including drought mortality. | Martin D. Venturas John S. Sperry Uwe G. Hacke | 2017 | Journal of Integrative Plant Biology2017，59，6： | 12 |
| 6 | Fixation of complex proximal humeral fractures in elderly patients with a locking plate: A retrospective analysis of radiographic and clinical outcome and complications显示文摘 | Fabio Rodia Emmanouil Theodorakis Georgios Touloupakis Angelo Ventura | 2016 | Chinese Journal of Traumatology2016，19，3： | 10 |
| 7 | 锦屏深地核天体物理实验(JUNA)的首个结果:^(25)Mg(p,γ)^(26)Al反应92 keV共振的精确测量显示文摘银河系星际介质中的^(26)Al衰变发射的1.809 MeVγ射线是γ天文学的主要观测对象之一,是银河系中正在进行核合成的关键证据,也为核合成理论与天文观测进行比较提供一个重要基准.在大质量恒星氢燃烧中,^(26)Al主要通过^(25)Mg(p,γ)^(26)Al反应产生,因此该反应在1.809 MeVγ射线研究中起着重要的作用.在天体环境温度为0.1 GK左右时,^(25)Mg(p,γ)^(26)Al天体物理反应率主要由92 keV共振俘获过程决定.作为在中国锦屏地下实验室(CJPL)中锦屏核天体物理实验(JUNA)装置上进行的首个实验,本工作对^(25)Mg(p,γ)^(26)Al反应的92 keV共振进行了精确的实验测量,得到了该共振的共振强度为ωγ=(3.80.3)10^(-10) eV,基态分支比为f0=0.660.04.与之前的工作相比,本工作大大提高了92 keV共振数据的精度.基于测量的92 keV共振参数和以前的间接测量结果,得到了精度最高的^(25)Mg(p,γ)^(26)Al天体物理反应率.结果表明,在0.1 GK左右时,新的反应率比REACLIB数据库中采用的反应率大2.4倍,这将导致^(26)Al和宇宙1.809 MeVγ射线的产额提高.同时,新反应率也将对理解太阳系的形成、球状星团的元素丰度反相关等问题提供重要的数据支撑. | 苏俊 张昊 李志宏 Paolo Ventura 李云居 李二涛 陈晨 谌阳平 连钢 郭冰 李鑫悦 张立勇 何建军 盛耀德 陈银吉 王泺欢 张龙 曹富强 南巍 南威克 李歌星 宋娜 崔保群 陈立华 马瑞刚 张智程 焦韬瑜 高丙水 唐晓东 吴启 李家庆 孙良亭 王硕 颜胜权 廖俊辉 王友宝 曾晟 南丁 樊启文 祁宁春 孙文良 郭绪元 张鹏 陈云华 周永 周济芳 何金荣 商长松 李名川 程建平 柳卫平 锦屏深地核天体物理合作组 | 2022 | Science Bulletin2022，67，2： | 8 |
| 8 | 近断层地震动对高层建筑结构抗震性能的影响显示文摘近断层地震地面运动区别于远场地震,具有滑冲效应特性和向前方向性效应特性.其中,具有单方向速度脉冲和阶跃式永久位移的滑冲效应对长周期结构影响较大.取1999年Turkey地震中台站SKR带有滑冲效应的近断层地震记录作为输入获得弹性和弹塑性反应谱,并详细分析具有不同大小线性特征周期的单自由度体系从线性发展到非线性的整个过程中滑冲效应的作用.以某典型的钢筋混凝土剪力墙高层建筑结构为例,具体研究近断层地震滑冲效应对结构抗震性能的影响.结果表明,近断层地震滑冲效应除了对较长周期的高层结构抗震性能具有不利影响之外,对可能产生较大非线性变形的短周期结构的影响同样不可忽视. | 李旭 Carlos Estuardo Ventura 何敏娟 | 2012 | 同济大学学报(自然科学版)2012，40，1： | 7 |
| 9 | Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease:Effect of N-acetyl transferase polymorphisms显示文摘AIM: To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate(5-ASA) interruption and the role of genetic polymorphisms of N-acetyl transferase(NAT) 1 and 2. METHODS: Concentrations of thioguanine nucleotides(TGN) and methymercaptopurine nucleotides(MMPN), metabolites of thiopurines, were measured by high performance liquid chromatography in 12 young patients(3 females and 9 males, median age 16 years) with inflammatory bowel disease(6 Crohn's disease and 6 ulcerative colitis) treated with thiopurines(7 mercaptopurine and 5 azathioprine) and 5-ASA. Blood samples were collected one month before and one month after the interruption of 5-ASA. DNA was extracted and genotyping of NAT1, NAT2, inosine triphosphate pyrophosphatase(ITPA) and thiopurine methyl transferase(TPMT) genes was performed using PCR assays. RESULTS: Median TGN concentration before 5-ASA interruption was 270 pmol/8 x 108 erythrocytes(range: 145-750); after the interruption of the aminosalicylate, a 35% reduction in TGN mean concentrations(absolutemean reduction 109 pmol/8 × 108 erythrocytes) was observed(median 221 pmol/8 × 108 erythrocytes, range: 96-427, P value linear mixed effects model 0.0011). Demographic and clinical covariates were not related to thiopurine metabolites concentrations. All patients were wild-type for the most relevant ITPA and TPMT variants. For NAT1 genotyping, 7 subjects presented an allele combination corresponding to fast enzymatic activity and 5 to slow activity. NAT1 genotypes corresponding to fast enzymatic activity were associated with reduced TGN concentration(P value linear mixed effects model 0.033), putatively because of increased 5-ASA inactivation and consequent reduced inhibition of thiopurine metabolism. The effect of NAT1 status on TGN seems to be persistent even after one month since the interruption of the aminosalicylate. No effect of NAT1 genotypes was shown on MMPN concentrations. NAT2 genotyping revealed that 6 patients presented a genotype corresponding to fast enzymatic activity and 6 to slow activity; NAT2 genotypes were not related to thiopurine metabolites concentration in this study. CONCLUSION: NAT1 genotype affects TGN levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs; however the number of patients evaluated is limited and this has to be considered a pilot study. | Gabriele Stocco Eva Cuzzoni Sara De Iudicibus Diego Favretto Noelia Malusà Stefano Martelossi Elena Pozzi Paolo Lionetti Alessandro Ventura Giuliana Decorti | 2015 | World Journal of Gastroenterology2015，21，12： | 5 |
| 10 | MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases显示文摘In spite of the introduction in therapy of highly effective biological agents,glucocorticoids(GCs)are still employed to induce remission in moderate to severe inflammatory bowel diseases(IBD),but considerable inter-individual differences in their efficacy and side effects have been reported.The effectiveness of these drugs is indeed very variable and side effects,particularly severe in pediatric patients,are common and often unpredictable:the understanding of the complex gene regulation mediated by GCs could shed light on the causes of this variability.In this context,microRNAs(miRNAs)represent a new and promising field of research.miRNAs are small non-coding RNA molecules that suppress gene expression at post-transcriptional level,and are fine-tuning regulators of diverse biological processes,including the development and function of the immune system,apoptosis,metabolism and inflammation.Emerging data have implicated the deregulated expression of certain miRNA networks in the pathogenesis of autoimmune and inflammatory diseases,such as IBD.There is a great interest in the identification of the role of miRNAs in the modulation of pharmacological response;however,the association between miRNA and GC response in patients with IBD has not yet been evaluated in a prospective clinical study.The identification of miRNAs differently expressed as a consequence of GC treatment in comparison to diagnosis,represents an important innovative approach that could be translated into clinical practice.In this review we highlight the altered regulation of proteins involved in GC molecular mechanism by miRNAs,and their potential role as molecular markers useful for predicting in advance GC response. | Sara De Iudicibus Marianna Lucafò Stefano Martelossi Chiara Pierobon Alessandro Ventura Giuliana Decorti | 2013 | World Journal of Gastroenterology2013，19，44： | 4 |
| 11 | A comparative study on the alternating mesophilic and thermophilic two-stage anaerobic digestion of food waste显示文摘An alternating mesophilic and thermophilic two stage anaerobic digestion(AD) process was conducted. The temperature of the acidogenic(A) and methanogenic(M) reactors was controlled as follows: System 1(S1) mesophilic A-mesophilic M;(S2) mesophilic A-thermophilic M; and(S3)thermophilic A-mesophilic M. Initially, the AD reactor was acclimatized and inoculated with digester sludge. Food waste was added with the soluble chemical oxygen demand(SCOD) concentrations of41.4–47.0 g/L and volatile fatty acids of 2.0–3.2 g/L. Based on the results, the highest total chemical oxygen demand removal(86.6%) was recorded in S2 while S3 exhibited the highest SCOD removal(96.6%). Comparing S1 with S2, total solids removal increased by 0.5%; S3 on the other hand decreased by 0.1 % as compared to S1. However, volatile solids(VS) removal in S1, S2, and S3was 78.5%, 81.7%, and 79.2%, respectively. S2 also exhibited the highest CH4 content, yield, and production rate of 70.7%, 0.44 L CH4/g VSadded, and 1.23 L CH4/(L·day), respectively. Bacterial community structure revealed that the richness, diversity, evenness, and dominance of S2 were high except for the archaeal community. The terminal restriction fragments dendrogram also revealed that the microbial community of the acidogenic and methanogenic reactors in S2 was distinct. Therefore,S2 was the best among the systems for the operation of two-stage AD of food waste in terms of CH4production, nutrient removal, and microbial community structure. | Jey-R Sabado Ventura Jehoon Lee Deokjin Jahng | 2014 | Journal of Environmental Sciences2014，26，6： | 4 |
| 12 | 优化船用柴油机的性能以减少氧化硫SO_x排放物的形成显示文摘Optimization procedures are required to minimize the amount of fuel consumption and exhaust emissions from marine engines.This study discusses the procedures to optimize the performance of any marine engine implemented in a 0D/1D numerical model in order to achieve lower values of exhaust emissions.From that point,an extension of previous simulation researches is presented to calculate the amount of SOx emissions from two marine diesel engines along their load diagrams based on the percentage of sulfur in the marine fuel used.The variations of SOx emissions are computed in g/k W·h and in parts per million(ppm)as functions of the optimized parameters:brake specific fuel consumption and the amount of air-fuel ratio respectively.Then,a surrogate model-based response surface methodology is used to generate polynomial equations to estimate the amount of SOx emissions as functions of engine speed and load.These developed non-dimensional equations can be further used directly to assess the value of SOx emissions for different percentages of sulfur of the selected or similar engines to be used in different marine applications. | Mina Tadros Manuel Ventura C.Guedes Soares | 2020 | Journal of Marine Science and Application2020，19，3： | 4 |
| 13 | Meckel's diverticulum masked by a long period of intermittent recurrent subocclusive episodes显示文摘Meckel's diverticulum(MD) is the most frequent congenital abnormality of the small bowel and it is often diff icult to diagnose.It is usually asymptomatic but approximately 4% are symptomatic with complications such as bleeding,intestinal obstruction,and inflammation.The authors report a case of a 7-year-old boy with a one-year history of recurrent periumbilical colicky pain with associated alimentary vomiting,symptoms erroneously related to a cyclic vomiting syndrome but not to MD.The clinical features and the differential diagnostic methods employed for diagnosis of MD are discussed. | Daniela Codrich Andrea Taddio Jurgen Schleef Alessandro Ventura Federico Marchetti | 2009 | World Journal of Gastroenterology2009，15，22： | 3 |
| 14 | Computed tomographic colonography in subjects with positive faecal occult blood test refusing optical colonoscopy显示文摘 | Lapo Sali Grazia Grazzini Leonardo Ventura Massimo Falchini Alessandra Borgheresi Guido Castiglione Michele Grimaldi Nicola Ianniciello Beatrice Mallardi Marco Zappa Mario Mascalchi | 2012 | Digestive and Liver Disease2012，，： | 3 |
| 15 | Obesity and Cardiovascular Disease显示文摘 | Carl J. Lavie Richard V. Milani Hector O. Ventura | 2009 | Journal of the American College of Cardiology2009，，21： | 3 |
| 16 | Two-dimensional near-infrared photonic crystal fabrication by generation of void channels in solid resin显示文摘Two-dimensional (2D) triangular void channel photonic crystals with different lattice constants stacked in two different directions were fabricated by using femtosecond laser micro-explosion in solid polymer material. Fundamental and higher-order stop gaps were observed both in the infrared transmission and reflection spectra. There is an approximately linear relationship between the gap position and the lattice constant. The suppression of the fundamental gap is as high as 70% for 24-layer structures stacked in the Г-M direction. | Michael James Ventura | 2003 | Chinese Optics Letters2003，1，12： | 3 |
| 17 | Crohn's disease and Takayasu's arteritis: An uncommon association显示文摘Takayasu’s arteritis(TA)and Crohn’s disease(CD)are two rare autoimmune disorders;however some reports describe the presence of both diseases in the same patient.This finding has suggested the possibility that both diseases could share some common etiologic origin.We describe a case of a 13-year-old male affected by CD characterized by fever,diarrhea,weight loss,abdominal pain and elevation of inflammatory markers.Clinical and histological features from colonic specimens were consistent with CD.Treatment with steroids and azathioprine was started,however disease flared every time steroids were tapered.One year later,while still on treatment,he came back to our attention for dyspnea at rest and at night,tiredness and weakness.At physical examination a diastolic heart murmur was found as well as a left carotid artery bruit.A transthoracic echocardiography showed mild aortic valve insufficiency,left ventricular hypertrophy and a dilated ascending aorta with same findings at the aortic arch.A computed tomography scan showed abdominal aortathickening,dilated thoracic aorta and the presence of a thoracic aortic aneurysm.TA associated with CD was diagnosed and medical treatment with cyclophosphamide,steroids and aminosalicylic acid was started,with good clinical response at 6 mo follow-up.We discuss the presence of possible common causes for the two diseases and the importance of differential diagnosis in those patients characterized for intractable disease. | Andrea Taddio Massimo Maschio Stefano Martelossi Egidio Barbi Alessandro Ventura | 2013 | World Journal of Gastroenterology2013，19，35： | 3 |
| 18 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)显示文摘暴露于ΣMWPm与任何胎儿大小或胎儿发育结局(见补充材料,表8)及所评估的出生结局(表2及补充材料表S7)都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性(-4.88%;95%CI:-8.36,-1.36),且与EFW增长减低也有显著相关性(-4.32%;95%CI:-8.33,-0.27)(图3及补充材料表S8)。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，9： | 3 |
| 19 | Density functional investigation of atmospheric sulfur chemistry Ⅱ: The heat of formation of the XSO2 radical X=H, CH3 显示文摘 | Denis P A Ventura O N | 2001 | Chem Phys Lett2001，344，： | 2 |
| 20 | Association between orofacial granulomatosis and Crohn's disease in children:Systematic review显示文摘AIM:To review pediatric cases of orofacial granulomatosis(OFG),report disease characteristics,and explore the association between OFG and Crohn’s disease.METHODS:We conducted a systematic review according to the PRISMA guidelines.We searched Medline,LILACS,Virtual Health Library,and Web of Knowledge in September 2013 for cases of OFG in the pediatric age range(<18 years),with no language limitations.All relevant articles were accessed in full text.The manual search included references of retrieved articles.We extracted data on patients’characteristics,disease characteristics,association with other diseases,and treatment.We analyzed the data and reported the results in tables and text.RESULTS:We retrieved 173 reports of OFG in children.Mean age at onset was 11.1±3.8 years(range:2.0-18years).Prevalence in males was significant higher than in females(P<0.001),with a male:female ratio of 2:1.Gastrointestinal signs or symptoms were present in 26.0%of children at the time of OFG diagnosis.Overall,70/173(40.4%)children received a concomitant diagnosis of Crohn’s disease.In about half(51.4%)of the cases the onset of OFG anticipated the diagnosis of Crohn’s disease,with a mean time between the two diagnoses of 13.1±11.6 mo(range:3-36 mo).Overall,21/173(12.1%)of the children with OFG had perianal disease,while 11/173(6.4%)had a family history of Crohn’s disease.Both perianal disease and a family history of Crohn’s disease were significantly associated with a higher risk of Crohn’s disease diagnosis in children with OFG[relative risk(RR)=3.10,95%confidence interval(CI):2.46-3.90;RR=2.74,95%CI:2.24-3.36,P<0.0001 for both).Treatment of OFG included steroids(70.8%of children)and other immunosuppressive drugs(42.7%),such as azathioprine,thalidomide and infliximab.CONCLUSION:High prevalence of Crohn’s disease in children with OFG suggests that OFG may be a subtype of Crohn’s disease. | Marzia Lazzerini Matteo Bramuzzo Alessro Ventura | 2014 | World Journal of Gastroenterology2014，20，23： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员