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| 1 | Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo显示文摘Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully understood.Here we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner.The inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of ovary.Gene expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen deficiency.Estrogen replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four weeks.Our data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in vivo.Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling. | Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann Drummond Evan R.Simpson Jun-Ping Liu | 2011 | Protein & Cell2011，2，4： | 8 |
| 2 | Characterization of the genetic locus responsible for the production of ABP-118,a novel bacteriocin produced by the probiotics bacterium lactobacillus salivarius subspsalivarius UCC118显示文摘 | Flynn S Van Sinderen D Thorn GM | 2002 | Microbiology2002，148，4： | 1 |
| 3 | Risk assessment of genetically modified lactic acid bacteria using the concept of substantial equivalence 显示文摘 | LEBLANC J G van SINDEREN D HUGENHOLTZ J | 2010 | Curr Microbiol2010，61，6： | 1 |
| 4 | Architecture and specification style in formal descriptions of distributed systems显示文摘 | Vissers C A Scollo G van Sinderen M | 1988 | North-Holland:Protocol Specification Testing and Verification Ⅷ1988，，6： | 1 |
| 5 | Characterization of bacterioein-like inhibitory substances (BLIS) from sour- dough lactic acid l~aeteria and evaluation of their in vitro and in situ activity显示文摘 | Corsetti A Settanni L Van Sinderen D | 2004 | Journal of Applied Microbiolo- gy2004，96，3： | 1 |
| 6 | Characterizationof the genetic locus responsible for the production of ABP - 118,a novel bacteriocin produced by the probiotic bacteriumlactobacillus salivarius subsp salivarius UCCll8 显示文摘 | Van Sinderen D Thornton GM | 2002 | Microbiology2002，148，4： | 1 |
| 7 | Bifidobacterium breve UCC 2003 surface exopolysaccharide production is a beneficial trait mediating commensal-host interaction through immune modulation and pathogen protection显示文摘 | Fanning S Hall LJ van Sinderen D | 2012 | Gut Microbes2012，3，5： | 1 |
| 8 | Host–microbe interactions that facilitate gut colonization by commensal bifidobacteria显示文摘 | Marco Ventura Francesca Turroni Mary O’Connell Motherway John MacSharry Douwe van Sinderen | 2012 | Trends in Microbiology2012，，10： | 1 |
| 9 | Characterization of the genetic locus responsible for the production of ABP-118, a novel bacteriocin produced by the probiotic bacterium Lactobacillus salivarius subsp, salivarius UCCI18 显示文摘 | Flynn S van Sinderen D Thomton GM | 2002 | Microbiology2002，148，4： | 1 |
| 10 | Isolation and characterisation of a novel bacteriocin produced by Bacillus thuringiensis strain B439显示文摘 | AHERN M VERSCHUEREN S van SINDEREN D | 2003 | FEMS Microbiology Letters2003，220，： | 1 |
| 11 | The chrondroitin sulfate proteoglycan (CSPG4) regulates human trophoblast function 显示文摘 | Van Sinderen M Cuman C Winship A | 2013 | Placenta2013，34，10： | 1 |
| 12 | Lactobacillus phylogenomies-towards a reclassification of the genus显示文摘 | Claesson MJ van Sinderen D O'Toole PW | 2008 | International Journal of Systematic and Evolutionary Microbiology2008，58，12： | 1 |
| 13 | Six Putative Two-component Regulatory Systems Isolated from Lactococcus lactis subsp, cremoris MG1363 显示文摘 | O'CONNELL-MOTHERWAY M VAN SINDEREN D MOP _EL-DEVILLE F | 2000 | Genetics and Molecular Biology2000，146，： | 1 |
| 14 | Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective显示文摘 | Francesca Turroni Marco Ventura Ludovica F. Buttó Sabrina Duranti Paul W. O’Toole Mary O’Connell Motherway Douwe Sinderen | 2014 | Cellular and Molecular Life Sciences2014，，2： | 1 |
| 15 | Fermented func-tional foods based on probiotics and their biogenic metabolites显示文摘 | van SINDEREN D STANTON C ROSS R P | 2005 | CurrOpin Biotech2005，16，2： | 1 |
| 16 | Application of biological acidification to improve the quality and processability of wort produced from 50% raw barley显示文摘 | LOWE DP ULMER HM SINDEREN DV | 2004 | J Ind Brewing2004，110，2： | 1 |
| 17 | Identification and characterization of phage-resistance genes in temperate lactococcal bacteriophages显示文摘 | MCGRATH S FITZGERALD G F SINDEREN D | 2002 | Mol Microbiol2002，43，2： | 1 |
| 18 | Investigation of protein export in Bifidobacterium breve UCC2003显示文摘 | MACCONAILL L E FITZGERALD G F VAN SINDEREN D | 2003 | Applied and environmental microbiology2003，69，12： | 1 |
| 19 | I-dentification and characterization of lactococcal-proph- age-carried superinfection exclusion genes 显示文摘 | Mahony J McGrath S Fitagerald G F Sinderen D | 2008 | Appl Environ Microbiol2008，74，20： | 1 |
| 20 | Carbohydrate metabolism in Bifidobacteria显示文摘 | POKUSAEVA K FITZGERALD G F VAN SINDEREN D | 2011 | Genes&nutrition2011，6，3： | 1 |
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