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| 1 | Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge显示文摘While the incidence of gastric cancer has decreased worldwide in recent decades,the incidence of signetring cell carcinoma(SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer,which can be resected endoscopically in some cases and which has a better outcome than non-SRCC,and advanced gastric cancer,which is generally thought to have a worse prognosis and lower chemosensitivity than non-SRCC. However,the prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more advanced stage. It therefore remains unclear if a specific therapeutic strategy is justified,as the benefit of perioperative chemotherapy and the value of taxanebased chemotherapy are unclear. In this review we analyze recent data on the epidemiology,oncogenesis,prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer. | Simon Pernot Thibault Voron Geraldine Perkins Christine Lagorce-Pages Anne Berger Julien Taieb | 2015 | World Journal of Gastroenterology2015，21，40： | 30 |
| 2 | Colorectal cancer and immunity:what we know and perspectives显示文摘Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer.In particular,the density of T CD8+and CD45+lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor.Other immune subsets,as macrophages,natural killer cells or unconventionnal lymphocytes,seem to play an important role.Induction of regulatory T cells(Tregs)or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response.The development of these mechanisms is a major obstacle to the establishment of an effective immune response,but also to the use of immunotherapy.Although im-munotherapy is not yet routinely used in colorectal cancer,we now know that most treatments used(chemotherapy and biotherapy)have immunomodulatory effects,such as induction of immunogenic cell death by chemotherapy,inhibition of immunosuppression by antiangiogenic agents,and antibody-dependent cytotoxicity induced by cetuximab.Finally,many immunotherapy strategies are being developed and tested in phaseⅠtoⅢclinical trials.The most promising strategies are boosting the immune system with cytokines,inhibition of immunoregulatory checkpoints,vaccination with vectorized antigens,and adoptive cell therapy.Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future. | Simon Pernot Magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb | 2014 | World Journal of Gastroenterology2014，20，14： | 19 |
| 3 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Patrice Cacoub David Saadoun Marc Bourlière Hacene Khiri Agnes Martineau Yves Benhamou Marina Varastet Stanislas Pol Vincent Thibault Michel Rotily Philippe Halfon | 2005 | Journal of Hepatology2005，，5： | 5 |
| 4 | Dairy manure as a potential source of crop nutrients and environmental contaminants显示文摘Although animal manure is applied to agricultural fields for its nutrient value,it may also contain potential contaminants.To determine the variability in such contaminants as well as in valuable nutrients,nine uncomposted manure samples from Idaho dairies collected during 2.5 years were analyzed for macro-and micro-nutrients,hormones,phytoestrogens,antibiotics,veterinary drugs,antibiotic resistance genes,and genetic elements involved in the spread of antibiotic resistance.Total N ranged from 6.8 to 30.7(C:N of 10 to 21),P from 2.4 to 9.0,and K from 10.2 to 47.7 g/kg manure.Zn(103-348 mg/kg)was more abundant than Cu(56-127 mg/kg)in all samples.Phytoestrogens were the most prevalent contaminants detected,with concentrations fluctuating over time,reflecting animal diets.This is the first study to document the presence of flunixin,a non-steroidal anti-inflammatory drug,in solid stacked manure from regular dairy operations.Monensin was the most frequently detected antibiotic.Progesterones and sulfonamides were regularly detected.We also investigated the relative abundance of several types of plasmids involved in the spread of antibiotic resistance in clinical settings.Plasmids belonging to the Inc I,Inc P,and Inc Q1 incompatibility groups were found in almost all manure samples.Inc Q1 plasmids,class 1 integrons,and sulfonamide resistance genes were the most widespread and abundant genetic element surveyed,emphasizing their potential role in the spread of antibiotic resistance.The benefits associated with amending agricultural soils with dairy manure must be carefully weighed against the potential negative consequences of any manure contaminants. | Danika Hill Matthew J.Morra Thibault Stalder Sven Jechalke Eva Top Anne T.Pollard Inna Popova | 2021 | Journal of Environmental Sciences2021，33，2： | 4 |
| 5 | 区块链与智能合约形成的共谋显示文摘一、引言区块链可能会像互联网改变信息的传播与性质一样改变交易。2如果设想成真,那么公司之间的所有关系都会改变,包括被法律禁止的关系。因此,区块链引发的权益问题十分值得关注,3但致力于该问题的学术研究却严重缺乏,这一状况必须得到改变。对该问题的相关研究必须尽快得到补充,因为随着技术的不断发展,法律在区块链中的适用也变得日趋复杂。因此,反托拉斯法与竞争法保持与时俱进是至关重要的,这些法律在规制技术所产生的力量及公司之间的互动方式上发挥了重要作用。本文旨在通过对区块链和共谋协议之间的相互作用进行研究,为反托拉斯法和竞争法的现代化作出贡献。 | Thibault Schrepel 时建中(译) 童肖安图(译) | 2021 | 竞争政策研究2021，，1： | 4 |
| 6 | 由两倍汽球 enteroscopy 的小肠 polypectomy : 与优先的囊内视镜检查法的关联显示文摘 AIM:To investigate the feasibility of small bowel polypectomy using double balloon enteroscopy and to evaluate the correlation with capsule endoscopy(CE).METHODS:This is a retrospective review of a single tertiary hospital.Twenty-five patients treated by enteroscopy for small bowel polyps diagnosed by CE or other imaging techniques were included.The correlation between CE and enteroscopy(correlation coefficient of Kendall for the number of polyps,intra-class coefficient for the size and coefficient of correlation kappa for the location) was evaluated.RESULTS:There were 31 polypectomies and 12 endoscopic mucosal resections with limited morbidity and no mortality.Histological analysis revealed 27 hamartomas,6 adenomas and 3 lipomas.Strong agreement between CE and optical enteroscopy was observed for both location(Kappa value:0.90) and polyp size(Kappa value:0.76),but only moderate agreement was found for the number of polyps(Kendall value:0.47).CONCLUSION:Double balloon enteroscopy is safe for performing polypectomy.Previous CE is useful in selecting the endoscopic approach and to predicting the difficulty of the procedure. | Gabriel Rahmi Elia Samaha Camille Lorenceau-Savale Bruno Landi Joёl Edery Thibault Manière Jean-Marc Canard Georgia Malamut Gilles Chatellier Christophe Cellier | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 7 | Association Between Diabetes and Stroke Subtype on Survival and Functional Outcome 3 Months After Stroke: Data From the European BIOMED Stroke Project显示文摘 | Salah-Eddine Megherbi Chantal Milan Dominique Minier Grégory Couvreur Guy-Victor Osseby Kate Tilling Antonio Di Carlo Domenico Inzitari Charles D.A. Wolfe Thibault Moreau Maurice Giroud | 2003 | Stroke: Journal of the American Heart Association2003，，3： | 3 |
| 8 | A Concept of Dynamically Reconfigurable Real-time Vision System for Autonomous Mobile Robotics显示文摘这篇论文描述被奉献在移动式机器人被嵌入的视觉系统的特定的限制。如果因为它的通用性,灵活性,性能,和费用,基于 PC 的硬件体系结构在这域里是方便的,当前的实时操作系统完全没被改编渴望与改变持续时间处理,并且它对经常必要太大保证设有自动保险装置的工作的系统。另外,和有更多的优先级的另外的机器的任务的相互作用是困难的处理。回答这个问题,我们发展了一动态地交换子可计算的视觉处理系统,基于有关安排和容错的 Cl é opatre 即时可适用的层的创新特征。这个框架允许定义紧急情况和可选的任务为机器人的另外的分系统保证最小的服务质量,当允许动态地改编处理链到的视觉时一在持续视觉过程或处理器超载上非凡。因此,它在单个硬件允许几个分系统的更好的同居,并且他们将为常规盒子并且不被设计开发不太昂贵却安全的系统,,稀罕的非凡的。最后,认为并且发展视觉系统带一个新方法,与一些求反运算符。 | Aymeric De Cabrol Thibault Garcia Patrick Bonnin Maryline Chetto | 2008 | International Journal of Automation and computing2008，5，2： | 3 |
| 9 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 10 | 化粪池内部流态数值模拟与结构优化探讨显示文摘针对既有建筑的化粪池技术改造和性能提升问题,应用FLUENT软件对传统化粪池三维流场进行了数值模拟计算,并深入分析了传统化粪池内部流态特征,在此基础上,对传统化粪池的结构提出了改进建议。软件数值模拟的结果显示,改进后的化粪池内部流态得到一定程度的优化,有利于化粪池处理效果的提升。 | 吴珊 唐世文 赵锂 赵昕 Simon Thibault | 2013 | 给水排水2013，39，5： | 2 |
| 11 | 极简鞋与坡度对跑步时垂直刚度和下肢刚度的影响(英文)显示文摘目的:采用运动学数据描述和比较传统跑鞋和极简鞋在下坡、平坡和上坡跑步时对垂直刚度和下肢刚度的影响。方法:受试者为14名男性业余跑步者(年龄23.4±4.4岁,身高177.5±5.2 cm,体重69.5±5.3 kg)。要求一周内完成2次测试,每次测试时,受试者以10 km/h的速度在跑步机上进行7组(每组5 min)跑步,组间有5 min坐式休息。每组试验在-8%(下坡)到+8%(上坡)的范围内随机选择不同的坡度跑步。在每组试验中,要求所有受试者穿极简鞋跑步(5 min),随后再穿传统跑鞋跑步(5 min),以确保每个坡度各有一次随机平衡条件下的两种鞋对比试验。采用光电测试系统和高速摄像机采集运动学数据,计算出垂直刚度和下肢刚度。结果:在不同坡度跑时,极简鞋组的下肢压缩、触地时间和质心垂直位移均明显小于传统跑鞋组。随着倾斜角度增加,两组鞋的步频均显著增大。运动学分析显示,在相似的坡度跑时,极简鞋组的下肢刚度高于传统鞋组,在垂直刚度上两组鞋并无差异,但均会随着坡度的增加而增加。结论:不同的鞋和(或)坡度能对跑步时垂直刚度和下肢刚度产生不同影响。本研究采用两种刚度的测量方法,为理解不同条件下跑步的生物力学适应提供了独特视角。同时,通过量化各种刚度能进一步加深理解跑步者的训练、运动表现和损伤。 | Thibault Lussiana Kim Hbert-Losier Laurent Mourot | 2015 | Journal of Sport and Health Science2015，4，2： | 2 |
| 12 | Laparoscopic versus open distal pancreatectomy: a single-institution case-control study显示文摘 | Sanket Sharad Mehta Ghalia Doumane Thibault Mura David Nocca Jean-Michel Fabre | 2012 | Surgical Endoscopy2012，，2： | 2 |
| 13 | Cell wall polysaccharide interactions in maize bran显示文摘 | Saulnier L Marot C Chanliaud E Thibault JF | 1995 | Carbohydr Polymers1995，26，： | 2 |
| 14 | 3D numerical simulation of seagrass movement under waves and currents with GPUSPH显示文摘The current study tries a new approach to simulating interactions between waves and seagrass through Smoothed Particle Hydrodynamics(SPH).In this model,the plants are defined as a solid that respects Hooke's law,and are assumed to have direct interaction with the fluid.Given the characteristics of the SPH method,especially in terms of computational time,the dimensions of the simulations were limited.The first goal of the current study was to optimize the approach to avoid reaching certain limits such as the rupture of the simulated plant.Plant movements under waves and/or currents have been studied by several authors in various in-situ,physical,and numerical experiments concerning various vegetation species,thus proving that plant movements can be successfully reproduced by SPH 2D/3D.Manning's roughness coefficient,n,was calculated to confirm that the results were in accordance with what had been measured in flume studies.Even though there is still room for improvement,it is shown that this method can be used to estimate Manning's coefficient for coastal vegetation(seagrass and saltmarsh vegetation)and to greatly improve the modeling and forecasting of coastal erosion and storm surge risks by including the effects of vegetation in integrated models. | Anne-Eleonore Paquier Thibault Oudart Caroline Le Bouteiller Samuel Meule Philippe Larroude Robert A.Dalrymple | 2021 | International Journal of Sediment Research2021，36，6： | 2 |
| 15 | Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest?) and transient elastography (FibroScan?)显示文摘 | Thierry Poynard Julien Vergniol Yen Ngo Juliette Foucher Mona Munteanu Wassil Merrouche Massimo Colombo Vincent Thibault Eugene Schiff Clifford A. Brass Janice K. Albrecht Marika Rudler Olivier Deckmyn Pascal Lebray Dominique Thabut Vlad Ratziu Victor de | 2013 | Journal of Hepatology2013，，： | 2 |
| 16 | Pilot study and protocol of the Canadian trial of atrial fibrillation (CTAF)显示文摘 | TALAJIC M THIBAULT B | 1997 | Am J Cardiol1997，80，4： | 1 |
| 17 | Enhancement of the current efficiency for sodium hydroxide production from sodium sulphate in a two-compartment bipolar membrane electrodialysis system显示文摘 | Paleogou M Thibault A Wong P Y | 1997 | Sep Purif Technol1997，11，1： | 1 |
| 18 | Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes显示文摘 | Rodius S Indra G Thibault C | 2007 | J Cell Physiol2007，212，2： | 1 |
| 19 | A 3D fictitious domain method for incompressible fluid flow problems 显示文摘 | Bertrand F Tanguy P A Thibault F | 1997 | International Journal of Numerical Methods Fluids1997，，25： | 1 |
| 20 | Carbon source requirements for exopolysaccharide production by LactobaciUus casei CGI 1 and partial structure analysis of the polymer显示文摘 | CERNING J RENARD C M G THIBAULT J E | 1994 | Applied and Environmental Microbiology1994，60，11： | 1 |
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