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| 1 | Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma:An intricate pathway显示文摘The histo-pathologic and molecular mechanisms leading to initiation and progression of hepatocellular carcinoma(HCC)are still ill-defined;however,there is increasing evidence that the gradual accumulation of mutations,genetic and epigenetic changes which occur in preneoplastic hepatocytes results in the development of dysplastic foci,nodules,and finally,overt HCC.As well as many other neoplasias,liver cancer is considered an'inflammatory cancer',arising from a context of inflammation,and characterized by inflammation-related mechanisms that favor tumor cell survival,proliferation,and invasion.Molecular mechanisms that link inflammation and neoplasia have been widely investigated,and it has been well established that inflammatory cells recruited at these sites with ongoing inflammatory activity release chemokines that enhance the production of reactive oxygen species.The latter,in turn,probably have a major pathogenic role in the continuum starting from hepatitis followed by chronic inflammation,and ultimately leading to cancer.The relationship amongst chronic liver injury,free radical production,and development of HCC is explored in the present review,particularly in the light of the complex network that involves oxidative DNA damage,cytokine synthesis,telomere dysfunction,and microRNA regulation. | Romilda Cardin Marika Piciocchi Marina Bortolami Andromachi Kotsafti Luisa Barzon Enrico Lavezzo Alessandro Sinigaglia Kryssia Isabel Rodriguez-Castro Massimo Rugge Fabio Farinati | 2014 | World Journal of Gastroenterology2014，20，12： | 14 |
| 2 | 多模聚合物波导在光电印制板中的应用显示文摘主要介绍了一种含多模聚合物波导的印制电路板制作方法及其测试结果。实验表明,这种多模聚合物波导印制电路板可以经受完整的印制电路板制程及可靠性测试,传输损耗约为0.03 d B/cm,波导之间的串扰<30 d B,10 Gbps下的眼图质量好。经过共平面及90°转向的耦合封装后,可以进行实际的高速信号传输。 | 吴金华 Marika Immonen 严惠娟 朱龙秀 彭增 时睿智 韩春华 | 2015 | 电子工艺技术2015，36，5： | 7 |
| 3 | 大流行的盘点:西班牙流感大流行和新型冠状病毒肺炎大流行的对比显示文摘人类历史上有明确记载的瘟疫或大流行至少有20多次。历史的经验教训值得借鉴,社会、科学和医学都在长足的进步,但人类仍在不断重复以前犯过的错误,漠视曾经有过的经历。本文是医学专家与历史学家合作,将本次新型冠状病毒肺炎大流行与100年前的西班牙流感大流行进行比较,以澳大利亚作为比较的落脚点,目的是从比较分析中发现和强调我们仍需要不断反思的政策和作为。研究者认为,相隔百年的两次大流行所处的人类社会背景已经发生巨大变化,最明显的是以信息时代为标志的社会经济和科学技术的全面进步,然而面对病毒病原体的来袭,人类社会采取的防疫策略和所犯错误竟也非常相似。研究者特别指出的是在传染病大流行期间,当医学系统在处理急性的威胁生命的危险时,往往忽视对心理健康造成的巨大影响,具体表现为焦虑、抑郁和物质使用障碍,特别是创伤后应激障碍,以及对家庭、医护人员、失业者、年轻人等社会弱势群体心理健康的影响。研究者分析了大流行三个阶段对心理健康影响的特点,并认为应该对新型冠状病毒肺炎大流行对全球社区的社会心理方面的急性和亚急性影响,以及即将到来的经济衰退对当代和后代人的身体和心理健康的长期影响,开展进一步研究。 | Leon Piterman Marika Vicziany 林楚玲(译) 黄文静(译) 杨辉(译) | 2021 | 中国全科医学2021，24，13： | 4 |
| 4 | Use of sequential extraction to assess metal partitioning in soils显示文摘 | Marika Kaasalainen Markku Yli-Halla | 2003 | Environmental Pollution2003，，2： | 2 |
| 5 | 优化磁性粒子为基础的系统的DNA纯化方案的重要性显示文摘从复杂生物基质中快速、高效地分离核酸是在获取各种实验的最佳起始原料的重要一步。磁性粒子为基础的操作流程提供了一个快速简单的解决方案,它特别适合用于自动化,在获得纯净和完整的DNA或RNA时以最少的动手时间获得良好的重现性结果。因此,必须优化基于磁珠的纯化流程来达到最高质量与数量的核酸提取。本文介绍了一个自动化、高速、以磁性粒子为基础的纯化系统来实现理想的DNA纯化方案,并考察了不同搅拌速度组合,以及在洗脱步骤的加热效应对DNA纯化数量和质量的影响。 | Marika SUOMALAINEN Sini SUOMALAINEN Virpi PURO Vuokko KYTNIEMI Arja LAMBERG | 2010 | 生命科学仪器2010，8，6： | 2 |
| 6 | Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard显示文摘 | Thierry Poynard Mona Munteanu Elena Luckina Hugo Perazzo Yen Ngo Luca Royer Larysa Fedchuk Florence Sattonnet Raluca Pais Pascal Lebray Marika Rudler Dominique Thabut Vlad Ratziu | 2013 | Journal of Hepatology2013，，5： | 2 |
| 7 | 利用环烷基油生产更为环保的轮胎显示文摘 | Marika Joona 薛小栋 | 2005 | 中国橡胶2005，21，24： | 2 |
| 8 | Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest?) and transient elastography (FibroScan?)显示文摘 | Thierry Poynard Julien Vergniol Yen Ngo Juliette Foucher Mona Munteanu Wassil Merrouche Massimo Colombo Vincent Thibault Eugene Schiff Clifford A. Brass Janice K. Albrecht Marika Rudler Olivier Deckmyn Pascal Lebray Dominique Thabut Vlad Ratziu Victor de | 2013 | Journal of Hepatology2013，，： | 2 |
| 9 | The effect of substrate on mycotoxin production of selected Penicillium strains显示文摘 | Kokkonen Meri Jestoi Marika Rizzo Aldo | 2005 | International Journal of Food Microbiology2005，99，： | 1 |
| 10 | Factors affecting the initial stiffness of cohesive soils显示文摘 | Marika Santagata John T Germaine Charies Ladd | 2005 | Journal of Geotechnical and Geoenvironmental Engineering2005，131，4： | 1 |
| 11 | The effect of vaccination against Porcine reproductive and respiratory syndrome virus (PRRSV) on the Porcine circo- virus-2 (PCV-2) load in porcine circovirus associated disease (PCVAD) affected pigs显示文摘 | Genzow Marika/M Schwartz Kent/K Gonzalez Glenda/G | 2009 | Can J Vet Res2009，3，2： | 1 |
| 12 | Risk of conversion to clinically definite multiple sclerosis in acute partial transverse myelitis and normal brain MRI显示文摘 | Ciofani A Marika J | 2006 | Neurology2006，66，5： | 1 |
| 13 | Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus,and parainfluenza viruses among young children 显示文摘 | MARIKA I KATTLRYN E PETER S | 2004 | Pediatrics2004，113，6： | 1 |
| 14 | Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis显示文摘 | Marika J Tatiana V | 2000 | Onco gene2000，19，3： | 1 |
| 15 | Analysis of the Fusarium mycotoxins fusaproliferin and trichothecenes in grains using gas chromatography-mass spectrometry显示文摘 | MARIKA J ALBERTO R AND A | 2004 | J Agric Food Chem2004，52，： | 1 |
| 16 | The Arctic’s rapidly shrinking sea ice cover: a research synthesis显示文摘 | Julienne C. Stroeve Mark C. Serreze Marika M. Holland Jennifer E. Kay James Malanik Andrew P. Barrett | 2012 | Climatic Change2012，，3： | 1 |
| 17 | Hyperbaric oxygen therapy with short duration intratympanic steroid ther- apy for sudden hearing loss 显示文摘 | Roberto F Giuseppe A Marika V | 2012 | Acta Oto - laryngologi- ca2012，，5： | 1 |
| 18 | Parainfluenza Virus Infection of Young Children: Estimates of the Population-Based Burden of Hospitalization显示文摘 | Geoffrey A. Weinberg Caroline B. Hall Marika K. Iwane Katherine A. Poehling Kathryn M. Edwards Marie R. Griffin Mary Allen Staat Aaron T. Curns Dean D. Erdman Peter G. Szilagyi | 2009 | The Journal of Pediatrics2009，，5： | 1 |
| 19 | Diagnostics of pulmonary embolism with emphasis on ventilation/perfusion scintigraphy and dead-space analysis显示文摘 | Bjorn J Marika B | 2006 | J Organ Dysfunction2006，17，： | 1 |
| 20 | D- LysAsnProTyr tetrapeptide:a novel B-cell stimp Lant and stabilized bursin mimetic 显示文摘 | Lyne Gagnon Marika DiMarco Robert Kirby et a2 | 2000 | Vaccine2000，18，18： | 1 |
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