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| 1 | Endoscopic diagnosis of extrahepatic bile duct carcinoma:Advances and current limitations显示文摘The accurate diagnosis of extrahepatic bile duct carcinoma is difficult,even now.When ultrasonography(US)shows dilatation of the bile duct,magnetic resonance cholangiopancreatography followed by endoscopic US(EUS)is the next step.When US or EUS shows localized bile duct wall thickening,endoscopic retrograde cholangiopancreatography should be conducted with intraductal US(IDUS)and forceps biopsy.Fluorescence in situ hybridization increases the sensitivity of brush cytology with similar specificity.In patients with papillary type bile duct carcinoma,three biopsies are sufficient.In patients with nodular or infiltrating-type bile duct carcinoma,multiple biopsies are warranted,and IDUS can compensate for the limitations of biopsies.In preoperative staging,the combination of dynamic multidetector low computed tomography(MDCT)and IDUS is useful for evaluating vascular invasion and cancer depth infiltration.However,assessment of lymph nodes metastases is difficult.In resectable cases,assessment of longitudinal cancer spread is important.The combination of IDUS and MDCT is useful for revealing submucosal cancer extension,which is common in hilar cholangiocarcinoma.To estimate the mucosal extenextension,which is common in extrahepatic bile duct carcinoma,the combination of IDUS and cholangioscopy is required.The utility of current peroral cholangioscopy is limited by the maneuverability of the“baby scope”.A new baby scope(10 Fr),called“SpyGlass”has potential,if the image quality can be improved.Since extrahepatic bile duct carcinoma is common in the Far East,many researchers in Japan and Korea contributed these studies,especially,in the evaluation of longitudinal cancer extension. | Kiichi Tamada Jun Ushio Kentaro Sugano | 2011 | World Journal of Clinical Oncology2011，2，5： | 26 |
| 2 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 3 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 4 | Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?显示文摘 | Susumu Hijioka Mohamed A. Mekky Vikram Bhatia Akira Sawaki Nobumasa Mizuno Kazuo Hara Waki Hosoda Yasuhiro Shimizu Kiichi Tamada Yasumasa Niwa Kenji Yamao | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 5 | Aminoguanidine attenuates endo toxin ind uced acute lung injury in rabbits显示文摘 | Mikawa K Nishina K Tamada M | | 0，，： | 2 |
| 6 | CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc ? and Thereby Promotes Tumor Growth显示文摘 | Takatsugu Ishimoto Osamu Nagano Toshifumi Yae Mayumi Tamada Takeshi Motohara Hiroko Oshima Masanobu Oshima Tatsuya Ikeda Rika Asaba Hideki Yagi Takashi Masuko Takatsune Shimizu Tomoki Ishikawa Kazuharu Kai Eri Takahashi Yu Imamura Yoshifumi Baba Mitsuyo O | 2011 | Cancer Cell2011，，3： | 2 |
| 7 | Human cerebellar activi ty reflecting an acquired internal model of a new tool显示文摘 | Imamizu H Miyauchi S Tamada T | 2000 | Nature2000，403，： | 1 |
| 8 | Apparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade显示文摘 | Tamada T Sone T Jo Y | 2008 | J Magn Reson Imaging2008，28，3： | 1 |
| 9 | B7-H1, athird member of the B7family, co-stimulates T-cell proliferation and interleukin-10 secretion 显示文摘 | Dong H D Zhu G F Tamada K | 1999 | Nat Med1999，5，12： | 1 |
| 10 | B7-H1 determines accumulation and deletion of intrahepatic CD8^+ T lymphocytes 显示文摘 | Dong H Zhu G Tamada K | 2004 | Immunity2004，20，3： | 1 |
| 11 | Expression of insulin-like growth factor-Ⅰ (IGF-Ⅰ) and its receptor in the peri-implantation mouse uterus, and cell-specific regulation of IGF-Ⅰ gene expression by estradiol and progesterone显示文摘 | Kapur S Tamada H Dey SK | 1992 | Biol Reprod1992，46，2： | 1 |
| 12 | Bile du-ct wall thickness measured by intraductal US in patients who have not undergone previous biliary drainage显示文摘 | TAMADA K TOMIYAMA T OOHASHI A | | 0，，02： | 1 |
| 13 | A quantification of goldfish behavior by an image processing system显示文摘 | Kato S Tamada K Shimada Y | 1996 | Behavioural Brain Research1996，80，12： | 1 |
| 14 | Efficacy of endoscopic retrogradecholecystoendoprosthesis ( ERCCE ) for chole- cystitis 显示文摘 | Tamada K Seki H Sato K | 1991 | Endoscopy1991，23，1： | 1 |
| 15 | A novel peculiar mutation in the sodium/iodide symporter gene in Spanish siblings with iodide transport defect显示文摘 | Koangi S Okamoto H Tamada A | 2002 | J Clin Endocrinol Metab2002，87，8： | 1 |
| 16 | Increasing gonadotropinreleasing hormone release by perifused hypothatamus from early to late anestrus in the Beagle bitch显示文摘 | Tani H Inaba T Tamada H | 1996 | Neurosci Lett1996，207，： | 1 |
| 17 | Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues显示文摘 | Tamada T Sone T Toshimitsu S | 2008 | J Magn Reson Imaging2008，27，3： | 1 |
| 18 | B7-H1,a third member of the B7 family,costimulates T-cell proliferation and interleukin-10 secretion显示文摘 | Dong H Zhu G Tamada K | 1999 | Nature Med1999，5，12： | 1 |
| 19 | Oncolytic virotherapy for malignant melanoma with herpes simplex virus type 1 mutant HF10显示文摘 | Daisuke Watanabe Fumi Goshima Isamu Mori Yasuhiko Tamada Yoshinari Matsumoto Yukihiro Nishiyama | 2007 | Journal of Dermatological Science2007，，3： | 1 |
| 20 | Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th - 2 priming 显示文摘 | Vassallo R Tamada K Lau JS | 2005 | J Immunol2005，175，4： | 1 |
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