|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis显示文摘AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice.CONCLUSION: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future. | Junmi Tanaka Hideo Tanaka Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura Masayuki Yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 5 |
| 2 | Defect control for large remnant polarization in bismuth titanate ferroelectrics-doping effect of higher-valent cations 显示文摘 | NOGUCHI Y MIWA I GOSHIMA Y | 2000 | Jpn J Appl Phys2000，39，： | 2 |
| 3 | M phase specific kinetochore proteins in fission yeast: microtubuleassociating Dis1 and Mtc1 display rapid seperation and segregation during anaphase显示文摘 | Nakaseko Y Goshima G Morishita J | 2001 | Curr Biol2001，11，8： | 2 |
| 4 | Xanthogranulomatous cholecystitis: Diagnostic performance of CT to differentiate from gallbladder cancer显示文摘 | Satoshi Goshima Samuel Chang Jin Hong Wang Masayuki Kanematsu Kyongtae T. Bae Michael P. Federle | 2009 | European Journal of Radiology2009，，3： | 2 |
| 5 | The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells 显示文摘 | Goldberg VM Caplan AI | 1991 | Clin Orthop1991，269，： | 1 |
| 6 | The Osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks显示文摘 | Goldberg VM Caplan AI | 1991 | Clin Orthop1991，262，： | 1 |
| 7 | Diffusion kurtosis imaging to assess response to treatment in hypervascular hepatocelIular carcinoma显示文摘 | Goshima S Kanematsu M Noda Y | 2015 | AJR Am J Roentgenol2015，204，5： | 1 |
| 8 | MDCT of the liver and hypervascular hepatocellular carcinomas :optimizing scan delays for bolus-tracking techniques of hepatic arterial and portal venous phases显示文摘 | Goshima S Kanematsu M Kondo H | 2006 | A JR Am J Roentgenol2006，187，1： | 1 |
| 9 | Oncolytic virotherapy for malignant melanoma with herpes simplex virus type 1 mutant HF10显示文摘 | Daisuke Watanabe Fumi Goshima Isamu Mori Yasuhiko Tamada Yoshinari Matsumoto Yukihiro Nishiyama | 2007 | Journal of Dermatological Science2007，，3： | 1 |
| 10 | MRI of the thyroid for dif-ferential diagnosis of benign thyroid nodules and papillary carcino-mas显示文摘 | Noda Y Kanematsu M Goshima S | 2015 | AJR2015，204，： | 1 |
| 11 | Evaluation of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C 57 black mouse model for parkinsonism 显示文摘 | Arai N Misugi K Goshima Y | 1990 | Brain Res1990，515，12： | 1 |
| 12 | Pilot Study of Oncolytic Viral Therapy Using Mutant Herpes Simplex Virus (HF10) Against Recurrent Metastatic Breast Cancer显示文摘 | Hideto Kimata MD PhD Tsuneo Imai MD PhD Toyone Kikumori MD PhD Osamu Teshigahara MD PhD Tetsuro Nagasaka MD PhD Fumi Goshima MD PhD Yukihiro Nishiyama MD PhD Akimasa Nakao MD PhD | 2006 | Annals of Surgical Oncology2006，，8： | 1 |
| 13 | Herpes simplex vires US3 protein kinase regulates vires-induced apoptosis in olfactory and vomemnasal chemosensory neurons in vivo 显示文摘 | Mori I Goshima F Watanabe D | 2006 | Microbes Infect2006，8，7： | 1 |
| 14 | High Voltage In- sulation Performance of Cryogenic Liquids for Supercon- ducting Power Apparatus 显示文摘 | Okubo H Hikita M Goshima H | 1996 | IEEE Transactions on Power Delivery1996，11，3： | 1 |
| 15 | Reproductive cycle and shell growth of transplanted Manila clam Ruclitapes philippinarum in Saroma Lagoon显示文摘 | Goshima S Ide N Fujiyoshi Y | 1996 | Nippon Suisan Gakkaishi1996，62，： | 1 |
| 16 | Effect of microstructure on fatigue behavior of AZ31 magnesium alloy显示文摘 | Sotomi Ishihara Zhenyu Nan Takahito Goshima | 2007 | Materials Science and Engineering A2007，，： | 1 |
| 17 | The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells显示文摘 | Goshima J Goldberg VM Caplan AI | 1991 | Clin Orthop1991，，269： | 1 |
| 18 | Characterization of cells with osteogenic potential from human marrow显示文摘 | Haynesworth SE Goshima J Goldberg VM | 1992 | Bone1992，，13： | 1 |
| 19 | Evaluation of a 1-methyl-4-phenyl-1, 2,3, 6-tetrahydropyridine ( MPTP )treated C57 black mouse model for parkinsonism 显示文摘 | Arai N Misugi K Goshima Y | 1990 | Brain Res1990，515，12： | 1 |
| 20 | The UL14 protein of herpes simplex virus type 2 translocates the minor capsid protein VP26 and the DNA cleavage and packaging UL33 protein into the nucleus of coexpressing cells显示文摘 | Yamauchi Y Wada K Goshima F | 2001 | J Gen Virol2001，82，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员