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| 1 | Current global trends in the incidence of pediatric-onset inflammatory bowel disease显示文摘AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts. | Josef Sykora Renta Pomahacov Marcela Kreslová Dominika Cvalínová Premysl Stych Jan Schwarz | 2018 | World Journal of Gastroenterology2018，24，25： | 27 |
| 2 | Photochemistry of copper complexes and their environmental aspects显示文摘 | Jan Sykora | 1997 | Coordination Chemistry Review1997，159，： | 1 |
| 3 | Searching for mechanisms that matter in early septic acute kidney injury:an experimental study显示文摘 | Jan Benes1 Jiri Chvojka Roman Sykora | 2011 | Critical Care2011，15，5： | 1 |
| 4 | Effects of a Specially Designed Fermented Milk Product Containing Probiotic Lactobacillus casei DN-114 001 and the Eradication of H. pylori in Children: A Prospective Randomized Double-Blind Study显示文摘 | Josef Sykora Kristyna Vale?ková Jana Amlerová Konrad Siala Petr Dědek Stephen Watkins Jana Varva?ovská Franti?ek Sto?icky Petr Pazdiora Jan Schwarz | 2005 | Journal of Clinical Gastroenterology2005，，8： | 1 |
| 5 | Gastric Emptying of Solids in Children with H. pylori-Positive and H. pylori-Negative Non-Ulcer Dyspepsia显示文摘 | Josef Sykora Alexander Malán Jan Záhlava Jana Varvar&OV0165 ká Franti?ek Stoz?cky Konrad Siala Jan Schwarz | 2004 | Journal of Pediatric Gastroenterology and Nutrition2004，，3： | 1 |
| 6 | Inflammatory bowel disease incidence in Czech children:A regional prospective study,2000-2015显示文摘AIM To examine the incidence and trends in pediatric inflammatory bowel diseases(IBDs) over 2000-2015 and project the incidence to 2018. METHODS A 16-year prospective study of IBD patients < 19 years of age was conducted in the Czech Republic(the Pilsen region). All incident IBD cases within a well-defined geographical area were retrieved from a prospectively collected computerized clinical database. Historical Czech data were used for comparison(1990-2001). Our catchment population was determined from the census data. We calculated the incidence by relating the number of newly diagnosed cases to the size of thepediatric population-at-risk in each calendar year. Age/sex, disease type, place of residence, and race/ethnicity were identified. RESULTS In total, 170 new IBD cases [105 Crohn's disease(CD), 48 ulcerative colitis(UC), and 17 IBD-unclassified(IBD-U)] were identified. The median age at IBD diagnosis was 14.2 years, 59.4% were males, and 97.1% were Caucasians. A male preponderance of IBD(P = 0.026) and CD(P = 0.016) was observed. With 109209 person-years in the catchment area, the average incidence of IBD per 100000 person-years was 10.0(6.2 for CD, 2.8 for UC, and 1.0 for IBD-U) for children aged 0 to 19 years; for those aged 0 to 15 years, the incidence rate was 7.3(4.6 for CD, 2.0 for UC, and 0.7 for IBD-U). An increase in incidence with age was observed(P = 0.0003). Over the 16-year period, the incidence increased for IBD patients(P = 0.01) and CD in particular(P < 0.0001), whereas the incidence for UC(P = 0.09) and IBD-U(P = 0.339) remained unchanged. IBD-projected data from 2016 to 2018 were 12.1, 12.3 and 12.6 per 100000 personyears, respectively.CONCLUSION Pediatric-onset IBD incidence is around its highest point. The increase, which is particularly pronounced for CD, may be challenging to relate to causes of pediatric disease. | Jan Schwarz Josef Sykora Dominika Cvalínová Renáta Pomahacová Jana Klecková Martin Kryl Petr Vcelák | 2017 | World Journal of Gastroenterology2017，23，22： | 0 |
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