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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Periampullary diverticula and pancreaticobilliary disease显示文摘 | Lobo DN Balfour TW Iftikhar SY | 1999 | Brit J Sugr1999，86，： | 1 |
| 3 | Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells显示文摘 | Khan N Afaq F Syed DN | 2008 | Carcinogenesis2008，29，5： | 1 |
| 4 | Health-seeking behaviour among adults with prolonged cough in Vietnam显示文摘 | HOA NB TIEMERSMA EW SY DN | 2011 | Trop Med Int Health2011，16，10： | 1 |
| 5 | Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polypheno! extract POMx 显示文摘 | Zaid MA Afaq F Syed DN | 2007 | Photochem Photohiol2007，83，： | 1 |
| 6 | Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappa B activation in normal human bronchial epithelial cells显示文摘 | Afaq F Kweon MH | 2007 | Oncogene2007，26，： | 1 |
| 7 | Periampullary diverticula and pancreatieobiliary disease 显示文摘 | Lobo DN Balfour TW Iftikhar SY | 1999 | Br J Surg1999，86，5： | 1 |
| 8 | Chemoprevention of prostate cancer through dietary agents: progress and promise 显示文摘 | Syed DN Khan N Afaq F | 2007 | Cancer Epidemiol Biomarkers Prev2007，16，11： | 1 |
| 9 | Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation显示文摘 | Syed DN Afaq F Sarfaraz S | | 0，，01： | 1 |
| 10 | Beijing genotyPe of Mycobacterium tuberculosis is significantly associated with-level ftuoroquinolone resistante in Vietnam显示文摘 | An DD Duyen NTH Lan NTN Hoa DV Ha DTM Sy DN Farrar J Caws M | 2009 | Antimicrob Agents Chemother2009，53，11： | 1 |
| 11 | Periampullary diverticula:consequences of failed ERCP显示文摘 | Balfour TW Iftikhar SY | 1998 | Ann R Coll Surg Engl1998，80，5： | 1 |
| 12 | Supplemental oxygen improves diabetic macular edema: a pilot study 显示文摘 | Quan DN Syed MS Elizabeth VA | 2004 | Invest Ophthal Vis Sci2004，45，2： | 1 |
| 13 | MicroRNAs in skin response to UV radiation显示文摘 | Syed DN Khan MI Shabbir M | 2013 | Curr Drug Targets2013，14，10： | 1 |
| 14 | Periampullary diverticula and pancreaticobiliary disease 显示文摘 | Lobo DN Balfour TW Iftikhar SY | 1999 | Br J Surg1999，86，5： | 1 |
| 15 | Periampullary diverticula and pancreaticobillary disease 显示文摘 | LOBO DN BAIFOUR TW IFTIKHAR SY | 1999 | Br J Surg1999，86，： | 1 |
| 16 | Periampullary diverticula and pancreaticobiliary disease 显示文摘 | LOBO DN ALFOUR TW LFIKHAR SY | 1999 | British Journal of Surgery1999，86，： | 1 |
| 17 | Delphinidin,an anthocyanidin in pig- mented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis 显示文摘 | Afag F Syed dn Malik A | 2007 | Invest Dermatol2007，127，1： | 1 |
| 18 | Tuberculous granulomas are hypoxic in Guinea pigs, rabbits, and nonhuman primates 显示文摘 | Via LE Lin PL Ray SM Carrillo J Allen SS Eum SY Taylor K Klein E Manjunatha U Gonzales J Lee EG Park SK Raleigh JA Cho SN Mcmurray DN Flynn JL Barry CE | 2008 | Infect Immun2008，76，6： | 1 |
| 19 | Delphinidin inhibits cell prolifera- tion and invasion via modulation of Met receptor phosphorylation 显示文摘 | Syed DN Afaq F Sarfaraz S | 2008 | Toxicol Appl Pharmacol2008，231，1： | 1 |
| 20 | Delphinidin,an antho- cyanidin in pigmented fruits and vegetables,protects human Ha- CaT keratinocytes and mouse skin against UVB-mediated oxida- tive stress and apoptosis显示文摘 | AFAQ F SYED DN MALIK A | 2007 | Invest Deraiatol2007，127，1： | 1 |
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