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| 1 | Aralia elata inhibits neurodegeneration by downregulating O-GlcNAcylation of NF-κB in diabetic mice显示文摘AIM:To investigate the role of O-GlcNAcylation of nuclear factor-kappa B(NF-κB) in retinal ganglion cell(RGC) death and analysedthe effect of Aralia elata(AE) on neurodegeneration in diabetic mice.METHODS: C57BL/6mice with streptozotocin-induced diabetes were fed daily with AE extract or control(CTL) diet at the onset of diabetes mellitus(DM). Two months after injection of streptozotocin or saline,the degree of cell death and the expression of O-GlcN Ac transferase(OGT),N-acetyl-b-D-glucosaminidase(OGA),O-GlcN Acylated proteins,and O-GlcNAcylation of NF-κB were examined.RESULTS: AE did not affect the metabolic status of diabetic mice. The decrease in the inner retinal thickness(P<0.001 vs CTL,P<0.01 vs DM) and increases in RGCs with terminal deoxynucleotidyl transferase-mediated d UTP nick end labelling(P<0.001 vs CTL,P<0.0001 vs DM),glial activation,and active caspase-3(P<0.0001 vs CTL,P<0.0001 vs DM) were blocked in diabetic retinas of AE extract-fed mice. Expression levels of protein O-Glc NAcylation and OGT were increased in diabetic retinas(P<0.0001 vs CTL),and the level of O-GlcNAcylation of the NF-κB p65 subunit was higher in diabetic retinas than in controls(P<0.0001 vs CTL). AE extract downregulated O-GlcNAcylation of NF-κB and prevented neurodegeneration induced by hyperglycemia(P<0.0001 vs DM).CONCLUSION: O-GlcNAcylation of NF-κB is concerned in neuronal degeneration and that AE prevents diabetes-induced RGC apoptosis via downregulation of NF-κB O-GlcNAcylation. Hence,O-GlcNAcylation may be a new object for the treatment of DR,and AE may have therapeutic possibility to prevent diabetes-induced neurodegeneration. | Seong-Jae Kim Min-Jun Kim Mee- Young Ckoi Yoon-Sook Kim Ji-Myong Yoo Eun-Kyung Hong Sunmi Ju Wan-Sung Choi | 2017 | International Journal of Ophthalmology(English edition)2017，10，8： | 3 |
| 2 | 用化学热解沉积法制备硫化镉薄膜的微结构(英文)显示文摘在载玻片或ITO涂覆的玻璃上采用化学热解法沉积CdS固体薄膜 ,沉积温度在 35 0~ 5 4 0℃之间 .部分制备的CdS薄膜进行 2 0 0~ 6 0 0℃的退火热处理 .由SEM ,AFM和XRD分析测量退火热处理前后的CdS薄膜的微观结构 .结果表明 ,沉积温度低于 5 4 0℃以下制备的CdS薄膜具有类六方结构相 ,当高于 5 4 0℃沉积的CdS薄膜则显示纤锌矿相 .在 4 0 0℃化学热解沉积的CdS薄膜经高于 5 0 0℃的后热处理也可获得纤锌矿相 . | Cha DeoKjoon Kim Sunmi 黄宁康 刘金蓉 陈剑 | 2004 | 红外与毫米波学报2004，23，1： | 2 |
| 3 | Enhanced neutraceutical serotonin derivatives of rice seed by hydroxycirmamoyl-coA: serotonin N-( hydroxycinnamoyl) transferase显示文摘 | Kiyoon Kang Sunmi Jang Sei Kang | 2005 | Plant Science2005，168，： | 1 |
| 4 | Major perfluoroalkyl acid (PFAA) concentrations and influence of food consumption among the general population of Daegu, Korea显示文摘 | Kyunghee Ji Sunmi Kim Younglim Kho Joon Sakong Domyung Paek Kyungho Choi | 2012 | Science of the Total Environment2012，，： | 1 |
| 5 | MIMO Partial Parallel Interference Cancellation for Space Time Block Coded MIMO-CDMA System 显示文摘 | SUNMI K JAEWON P YONGWAN P | 2006 | Advanced Communication Technology2006，，2022： | 1 |
| 6 | Ash-free coal as fuel for direct carbon fuel cell显示文摘This work describes the performance of the direct carbon fuel cell(DCFC)fuelled by ash-free coal.Employing coal in the DCFC might be problematic,mainly because of the ash deposition after the cell reactions.In the study,the carbonaceous ash-free component of coal is obtained,which is then evaluated as the DCFC fuel and compared with raw coal,active carbon,carbon black,and graphite.The electrolyte-supported SOFC structure is adapted to build the DCFC.The DCFC based on the ash-free coal fuel exhibits good performance with regard to the maximum power density,day-by-day measurements,and durability at continuous run.When the carbon fuels are internally gasified to H2 and CO,the power density is generally much improved,compared to N2 pyrolysis environment.The power generation is most likely related to the concentration of pyrolyzed gases as well as the electrochemical reactivity of the solid carbon. | LEE Injae JIN Sunmi CHUN Donghyuk CHOI Hokyung LEE Sihyun LEE Kibong YOO Jiho | 2014 | Science China Chemistry2014，57，7： | 1 |
| 7 | Elevated micro RNA ‐34a in obesity reduces NAD <sup>+</sup> levels and SIRT 1 activity by directly targeting NAMPT显示文摘 | Sung‐E Choi Ting Fu Sunmi Seok Dong‐Hyun Kim Eunkyung Yu Kwan‐Woo Lee Yup Kang Xiaoling Li Byron Kemper Jongsook K. Kemper | 2013 | Aging Cell2013，，6： | 1 |
| 8 | Study of Substance Changes in Flowers of Pueraria Thunbergiana 显示文摘 | CHUNG SOOK K SUNMI S HYEKYUNG H | 2003 | Arch Pharm Res2003，26，： | 1 |
| 9 | Syntheses and antitumor activities of medium molecular weight polymers containing α-ethoxy-exo-3,6-epoxy-1,2,3,6-tetrahydroph-thaloyl-5-fluorouracil 显示文摘 | Lee Sunmi Chol Wonmoon Ha Changsik | 1999 | J Polym Sci Part A: Polym Chem1999，37，14： | 1 |
| 10 | Study of substance changes in flowers of Pueraria thunbergiana 显示文摘 | CHUNGSOOK K SUNMI S HVEKVUNG H | 2003 | Arch Pharm Res2003，，26： | 1 |
| 11 | Fermentation Properties of Low-Salted DoenjangSupplemented with Licorice,Mustard,and Chitosan显示文摘 | Lim SeongIl Song Sunmi | 2010 | Korea Food Research Institute2010，42，3： | 1 |
| 12 | A study of diffusional behavior of n-paraffin in urea/n-paraffin adduct by high field-gradient HNMR spectroscopy显示文摘 | KIM Sunmi KIMURA Hideaki KUROKI Shigeki | 2003 | Chemical Physics Letters2003，367，56： | 1 |
| 13 | Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans显示文摘 | Eun Young Choi Eal Hwan Park Yoo Seock Cheong Insoo Rheem Seouk Gun Park Sunmi Yoo | 2006 | Metabolism2006，，3： | 1 |
| 14 | A novel fiber nolytic enzyme (nattokinase) in the vegetable cheese natto, a typical and popular soybean food in the Japanese diet显示文摘 | Sunmi H Hamada K Tsushima H | 1987 | Experientia1987，43，： | 1 |
| 15 | 芝麻灌浆规律研究初报显示文摘 | SUNMY(孙梅英) BAOJB(鲍敬保) WANGZT(王震庭) | | 河南农业科学0，，： | 1 |
| 16 | New Adaptive Clutter Rejection Based on Spectral Analysis for Ultrasound Color Doppler Imaging: Phantom and In Vivo Abdominal Study显示文摘 | Geunyong Park Sunmi Yeo Jae Jin Lee | 2014 | IEEE Transactions on Biomedical Engineering2014，61，1： | 1 |
| 17 | Differential expression of heat shock protein mRNAs under in vivo glutathione depletion in the mouse retina显示文摘 | Joo Wan Park Cheil Moon Sunmi Yun So Yeun Kim Yong Chul Bae Myung-Hoon Chun Jung-Il Moon | 2006 | Neuroscience Letters2006，，3： | 1 |
| 18 | Syntheses and antitumor activities of medium molecular weight polymers containing ct-ethoxy-exo-3,6-epoxy-1,2,3,6-tetra-hydroph-thaloyl-5-fluorouracil显示文摘 | Sunmi L Wonmoon C Changsik H | 1999 | J Polym Sci Part A : Polym Chem1999，37，14： | 1 |
| 19 | Effects of Urea on Hydrogen Peroxide Bleaching of Cotton Fabrics显示文摘 | Sunmi Yang Tahara Mitsuru Maekawa Masako | 2010 | Journal of the Society of Fiber Science & Technology2010，66，2： | 1 |
| 20 | Effeets of Urea on Hydrogen Peroxide Bleaching of Cotton Fabries显示文摘 | Sunmi Yang Tahara Mitsuru Maekawa Masako | 2010 | Jnurnal of the Society of Fiber Science & Technology2010，66，2： | 1 |
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