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| 1 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 2 | Outcomes of bowel program in spinal cord injury patients with neurogenic bowel dysfunction显示文摘In this study, we aimed to determine gastrointestinal problems associated with neurogenic bowel dysfunction in spinal cord injury patients and to assess the efficacy of bowel program on gastrointestinal problems and the severity of neurogenic bowel dysfunction. Fifty-five spinal cord injury patients were included in this study. A bowel program according to the characteristics of neurogenic bowel dysfunction was performed for each patient. Before and after bowel program, gastrointestinal problems(constipation, difficult intestinal evacuation, incontinence, abdominal pain, abdominal distension, loss of appetite, hemorrhoids, rectal bleeding and gastrointestinal induced autonomic dysreflexia) and bowel evacuation methods(digital stimulation, oral medication, suppositories, abdominal massage, Valsalva maneuver and manual evacuation) were determined. Neurogenic bowel dysfunction score was used to assess the severity of neurogenic bowel dysfunction. At least one gastrointestinal problem was identified in 44(80%) of the 55 patients before bowel program. Constipation(56%, 31/55) and incontinence(42%, 23/55) were the most common gastrointestinal problems. Digital rectal stimulation was the most common method for bowel evacuation, both before(76%, 42/55) and after(73%, 40/55) bowel program. Oral medication, enema and manual evacuation application rates were significantly decreased and constipation, difficult intestinal evacuation, abdominal distention, and abdominal pain rates were significantly reduced after bowel program. In addition, mean neurogenic bowel dysfunction score was decreased after bowel program. An effective bowel program decreases the severity of neurogenic bowel dysfunction and reduces associated gastrointestinal problems in patients with spinal cord injury. | Zuhal Ozisler Kurtulus Koklu Sumru Ozel Sibel Unsal-Delialioglu | 2015 | Neural Regeneration Research2015，10，7： | 9 |
| 3 | Glioblastoma stem cells:Molecular characteristics and therapeutic implications显示文摘Glioblastoma Multiforme(GBM)is a grade IV astrocytoma,with a median survival of 14.6 mo.Within GBM,stem-like cells,namely glioblastoma stem cells(GSCs),have the ability to self-renew,differentiate into distinct lineages within the tumor and initiate tumor xenografts in immunocompromised animal models.More importantly,GSCs utilize cell-autonomous and tumor microenvironment-mediated mechanisms to overcome current therapeutic approaches.They are,therefore,very important therapeutic targets.Although the functional criteria defining GSCs are well defined,their molecular characteristics,the mechanisms whereby they establish the cellular hierarchy within tumors,and their contribution to tumor heterogeneity are not well understood.This review is aimed at summarizing current findings about GSCs and their therapeutic importance from a molecular and cellular point of view.A better characterization of GSCs is crucial for designing effective GSCtargeted therapies. | Nermin Sumru Bayin Aram Sandaldjian Modrek Dimitris George Placantonakis | 2014 | World Journal of Stem Cells2014，6，2： | 3 |
| 4 | A comparison of tow methods used for measuring antagonistic activity of lactic acid bacteria显示文摘 | Bilge H C Sumru C | 2006 | Pakistan Journal of Nutrition2006，4，4： | 1 |
| 5 | Contrast-enhanced MR angiography of benign regenerative nodules following TIPS shunt procedure in Budd-Chiari syndrome 显示文摘 | Sumru T Ayse E Koray C | 2004 | Turk J Gastroenterol2004，15，： | 1 |
| 6 | Long-Term Results of Bare Sclera, Limbal-Conjunctival Autograft and Amniotic Membrane Graft Techniques in Primary Pterygium Excisions显示文摘 | ?zer Ahmet Yildirim Nilgün Erol Nazmiye Yurdakul Sumru | 2009 | Ophthalmologica2009，，4： | 1 |
| 7 | The isolation of Pseudomonas and other Gram (-) psychrotrophic bacteria in raw milks显示文摘 | Guven U Sumru C | 1998 | J Basic Microbiol1998，38，2： | 1 |
| 8 | FACT contrast sensitivity as a diagnostic tool in glaucoma显示文摘 | Sumru Onal Ozlem Yenice Sezen Cakir Ahmet Temel | 2008 | International Ophthalmology2008，，6： | 1 |
| 9 | Visual results and complications of posterior chamber intraoeular lens implatation after capsular tear during phaeoemulsification, oph- thalmic surgery显示文摘 | Sumru Onal MD Nilufer Gozum MD | 2004 | Lasers & Imaging2004，35，： | 1 |
| 10 | Refractive errors of medical students in Turkey:one year follow-up of refraction and biometry显示文摘 | Sumru O Toker E Akingol Z | | 0，，03： | 1 |
| 11 | Musculo-skeletal pain, quality of life and depression in mothers of children with cerebral palsy显示文摘 | Kurtulus Kaya Sibel Unsal-Delialioglu N. Kutay Ordu-Gokkaya Zuhal Ozisler Nilgun Ergun Sumru Ozel Halil Ucan | 2010 | Disability & Rehabilitation2010，，20： | 1 |
| 12 | Complete and incomplete market models 显示文摘 | Sumru G Altug | 2006 | Koc University and CEPR2006，，3： | 1 |
| 13 | Effects of phototherapy using different light sources on oxidant and antioxidant status of neonates with jaundice显示文摘 | Yusuf Kale Ozge Aydemir ülker Celik Sumru Kavurt Semra Isikoglu Ahmet Yagmur Bas Nihal Demirel | 2013 | Early Human Development2013，，： | 1 |
| 14 | Postoperative Pulmonary Embolism in a Young Female Accompanying with Factor V Leiden Mutation and Hereditary Sypherocytosis显示文摘 | Demet Karnak Sumru Beder Oya Kayacan ?zlem Berk | 2004 | Journal of Thrombosis and Thrombolysis2004，，3： | 1 |
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