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| 1 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 2 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 3 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 4 | Correlation between bovine milksomatic cell count and polymorphonuclear leukocyte level for samples of bulkmilk and milk from individual cows显示文摘 | Kelly A L Tiernan D O'Sullivan C | 2000 | Journal of Dairy Science2000，83，2： | 1 |
| 5 | SV40- encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells 显示文摘 | Sullivan C S Grundhoff A T Tevethia S | 2005 | Nature2005，435，7042： | 1 |
| 6 | Commercial quartz crystal microbalances - theory and applications显示文摘 | O'Sullivan C K Guilbault G G | 1999 | Biosens Bioelectron1999，14，： | 1 |
| 7 | Disparity mapping applied to sonography of the breast 显示文摘 | Steinberg B D Sullivan D C Carlson D L | 1998 | Radiology1998，207，2： | 1 |
| 8 | Predictive performance of three multivariate difficult tracheal intubation models:a double-blind,case-controlled study显示文摘 | Naguib M Scamman FL O'Sullivan C | 2006 | Anesth Analg2006，102，3： | 1 |
| 9 | The Fas counterattack : a molecular mechenism of tumor immune privilege 显示文摘 | O'Connell J Bennett M W O'Sullivan G C et aL | 1997 | Mol Med1997，3，： | 1 |
| 10 | Micrometastases in esophagogastric cancer:high detection rate in resected rib segments显示文摘 | O'SULLIVAN G C SHEEHAN D CLARKE A | 1999 | Gastroenterology1999，116，3： | 1 |
| 11 | The morphology and the mechanism of formation of porous anodic films on aluminium显示文摘 | O'Sullivan T Wood G C | 1970 | Proceed Royal Soc London Series A1970，317，： | 1 |
| 12 | The Formation of a Neptunium ( V )-Rhodium ( Ⅲ ) Complex: Kinetics and Equilibriums in Acidic Solutions显示文摘 | Murmann R K Sullivan J C | 1967 | Inorg Chem1967，6，5： | 1 |
| 13 | Coincident inactiva- tion of 14 3 3sigma and pl6INK4a is an early event in vulval squamous neop|asia显示文摘 | Gasco M Sullivan A Repellin C | 2002 | Oncogene2002，21，： | 1 |
| 14 | Patientswith head and neck cancer prefer individualized cognitivebehavioral therapy显示文摘 | Semple C J Dunwoody L Sullivan K | 2006 | Eur J Cancer Care (Engl)2006，15，3： | 1 |
| 15 | Effect of early breast milk expression on milk volume and timing of lac- togenesis stage II among mothers of very low birth weight infants: a pilot study 显示文摘 | Parker LA Sullivan S Krueger C | 2012 | J Perinatol2012，32，3： | 1 |
| 16 | Measurement o{ sleep in critically ill patients显示文摘 | Richards K C O'Sullivan P S Phillips R L | 2001 | J Nuts Meas2001，8，2： | 1 |
| 17 | The natural history of surgi- cally treated but radiotherapy-naive nonfunctioning pituitary adeno- mas显示文摘 | O'Sullivan EP Woods C Glynn N | 2009 | Clin Endocrinol (Oxf)2009，71，5： | 1 |
| 18 | Apparent digestibility of selected feedstuffs in diets for hybrid striped bass ( Morone saxatilis ♀ xMorone chrysops ♂ ) 显示文摘 | SULLIVAN J A REIGH R C | 1995 | Aquaculture1995，138，1234： | 1 |
| 19 | Zebrafish as a model for infectious disease and immune function显示文摘 | Sullivan C Kim CH | 2008 | Fish Shellfish Immunol2008，25，4： | 1 |
| 20 | Survival with congenital heart disease and need for follow up in adult life显示文摘 | Wren C O'Sullivan JJ | 2001 | Heart2001，85，4： | 1 |
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