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| 1 | Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy显示文摘There is an increasing interest in development of novel anticancer agents that target oncogenes.We have recently discovered that nuclear factor of activated T cells 1(NFAT1) is a novel regulator of the Mouse Double Minute 2(MDM2) oncogene and the NFAT1-MDM2 pathway has been implicated in human cancer development and progression,justifying that targeting the NFAT1-MDM2 pathway could be a novel strategy for discovery and development of novel cancer therapeutics.The present study was designed to examine the anticancer activity and underlying mechanisms of action of lineariifolianoid A(LinA),a novel natural product inhibitor of the NFAT1-MDM2 pathway.The cytotoxicity of LinA was first tested in various human cancer cell lines in comparison with normal cell lines.The results showed that the breast cancer cells were highly sensitive to LinA treatment.We next demonstrated the effects of LinA on cell proliferation,colony formation,cell cycle progression,and apoptosis in breast cancer MCF7 and MDA-MB-231 cells,in dose-dependent and p53-independent manners.LinA also inhibited the migration and invasion of these cancer cells.Our mechanistic studies further indicated that its anticancer activities were attributed to its inhibitory effects on the NFAT1-MDM2 pathway and modulatory effects on the expression of key proteins involved in cell cycle progression,apoptosis,and DNA damage.In summary,LinA is a novel NFAT1-MDM2 inhibitor and may be developed as a preventive and therapeutic agent against human cancer. | Jiang-Jiang Qin Sushanta Sarkar Sukesh Voruganti Rajesh Agarwal Wei Wang Ruiwen Zhang | 2016 | The Journal of Biomedical Research2016，30，4： | 5 |
| 2 | Synthesis of 4-acylpyrazolone Schiff base ligand grafted silica and selectivity in adsorption of lanthanides from aqueous solutions显示文摘The Schiff base form of the 4-acylpyrazolone ligand was immobilized on the silica surface by reaction of 3-aminopropyl silica with 4-acetyl-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one in 97% yield, producing grafted silica with 0.77 mmol/g ligand loading. This surface modified silica was shown to be selective in the adsorption of Yb3+ ions from dilute aqueous solutions, for which 98% adsorption was observed from a 1.0×10-5 mol/L aq. solution at pH 6.7, after 24 h at room temperature. Six other lanthanides studied Eu3+, Gd3+, Nd3+, Tb3+, Sm3+ and La3+ showed moderate to weaker adsorptions of 39%, 28%, 16%, 12%, 11% and 5% respectively under similar conditions. | Ananda S.Amarasekara Onome S.Owereh Sukesh K.Aghara | 2009 | Journal of Rare Earths2009，27，5： | 2 |
| 3 | Risk factors of thrombosis in abdominal veins显示文摘AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT). METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factorsare significantly more common in SVT patients while hereditary factors are similar in both groups. | Amit Kumar Dutta Ashok Chacko Biju George Joseph Anjilivelil Joseph Sukesh Chandran Nair Vikram Mathews | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 4 | Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ,a novel anticancer makaluvamine analog,and application in a pharmacokinetic study in rats显示文摘We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers.Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog,TCBA-TPQ,and conducted a pharmacokinetic study in laboratory rats.Our results indicated that the HPLC-MS/MS method was precise,accurate,and specific.Using this method,we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats.Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog. | YU Jun-Xian Sukesh Voruganti LI Dan-Dan Jiang-Jiang Qin Subhasree Nag Su Xu Sadanandan E.Velu Wei Wang Ruiwen ZHANG | 2015 | Chinese Journal of Natural Medicines2015，13，7： | 2 |
| 5 | A Novel Method For Pesticide Analysis in Re- fined Sugar Samples Using a Gas Chromatography- Mass Spectrometer (GC-MS/MS) and Simple Solvent Extraction Method 显示文摘 | SUKESH N S BHATNAGAR V K TOTEJA G S | 2011 | Food Chemistry2011，126，1： | 1 |
| 6 | A Novel Method For Pesticide Analysis in Refined Sugar Samples Using a Gas Chromatography-Mass Spectrometer (GC-MS/MS) and Simple Solvent Extraction Method显示文摘 | SUKESH N S BHATNAGAR V K TOTEJA G S | 2011 | Food Chemistry2011，126，1： | 1 |
| 7 | Effect of dissocia- tion energy on ion formation and sensitivity o{ an analyti- cal method for determination of ehlorpyrifos in human blood, using gas chromatography-mass spectrometer (GC- MS in MS/MS)显示文摘 | Sukesh N S Ramavati P Aruna D | 2006 | International Journal of Mass Spec- trometry2006，253，12： | 1 |
| 8 | A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study显示文摘 | Dhurat R Sukesh M Avhad G | 2013 | Int J Trichology2013，5，1： | 1 |
| 9 | Outside Directors and Board Advising and Monitoring Performance显示文摘 | Kyonghee Kim Elaine Mauldin Sukesh Patro | 2014 | Journal of Accounting and Economics2014，，57： | 1 |
| 10 | Outside directors and board advising and monitoring performance显示文摘 | Kyonghee Kim Elaine Mauldin Sukesh Patro | 2014 | 2014 (2-3)2014，，2： | 1 |
| 11 | Role of selenium supplementation and heat stress on trehalose and glutathione content in Saccharomyces cerevisiae显示文摘 | Sukesh Chander Sharma Maninder Singh Anand | 2006 | Applied Biochemistry and Biotechnology2006，，1： | 1 |
| 12 | A heteropolysaccharide from aqueous extract of an edible mushroom, Pleurotus ostreatus cultivar: structural and biological studies显示文摘 | Kankan K. Maity Sukesh Patra Biswajit Dey Sanjoy K. Bhunia Soumitra Mandal Debsankar Das Dibyendu K. Majumdar Swatilekha Maiti Tapas K. Maiti Syed S. Islam | 2010 | Carbohydrate Research2010，，2： | 1 |
| 13 | Determinants of the Size and Composition of US Corporate Boards:1935-2000显示文摘 | Kenneth M.Lehn Sukesh Petro Mengxin Zhao | | 0，，04： | 1 |
| 14 | An Analysis of Managerial Use and Market Con- sequences of Earnings Management and Expecta- tion Management 显示文摘 | Somnath Das Kyonghee Kim and Sukesh Patro | 2011 | The Accounting Review2011，，6： | 1 |
| 15 | Investigation on space charge and charge trap characteristics of gamma-irradiated epoxy micro–nano composites显示文摘Epoxy nano–micro composite specimen prepared with micro silica and ion trapping nanoparticle,by shear mixing process,was exposed to gamma radiation and its performance for space charge and charge trap characteristics were analysed.The threshold for space charge accumulation of epoxy nanocomposites reduces and rate of space charge accumulation increases with an increase in dosage of gamma irradiation.The average growth of space charge density during poling and charge decay rate during depoling are relatively higher for gamma-irradiated specimens than the virgin specimen.The initial surface potential has a marginal reduction with increase in the dosage of gamma radiation,but the surface potential decay rate has increased significantly.Trap distribution characteristics indicate more number of shallow traps and increase in charge mobility after irradiation.The relative permittivity and loss tangent of the specimens have high impact due to gamma irradiation.The activation energy calculated from DC conductivity by Arrhenius law reduces with increment in radiation dose.Laser-induced breakdown spectroscopy reflected no change in elemental composition with gamma-irradiated specimen.The variation in plasma temperature and ion line to atomic line intensity ratio with dosage of gamma radiation have direct correlation to the Vickers hardness number of the specimens. | Myneni Sukesh Babu Ramanujam Sarathi Nilesh Jayantilal Vasa Takahiro Imai | 2020 | High Voltage2020，5，2： | 1 |
| 16 | A possible role of trehalose in osmotolerance and ethanol tolerance in Saccharomyces cerevisiae显示文摘 | Sukesh Chander Sharma | 1997 | FEMS Microbiology1997，152，： | 1 |
| 17 | Thermal decomposition of viscose rayon in the presence of inorganic additives: a kinetic study显示文摘 | Venkateswaran R Babu S Sukesh Kumar S | 1990 | Journal of Applied Polymer Science1990，41，1112： | 1 |
| 18 | Outside direc- tors and board advising and monitoring performance 显示文摘 | Kyonghee Kim Elaine Mauldin Sukesh Patro | 2014 | Journal of Accounting and Economics2014，57，： | 1 |
| 19 | A possible role of trehalose in osmotolerance and ethanol tolerance in Saccharomyces cerevisiae 显示文摘 | Sukesh CS | 1997 | FEMS Microbiology Letters1997，152，： | 1 |
| 20 | Analysis and implementation of a single-stage flyback PV microinverter with Soft switching显示文摘 | Sukesh N Pahlevaninezhad M Jain P K | 2014 | IEEE Transactions on Industrial Electronics2014，61，4： | 1 |
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