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| 1 | Current understanding of the molecular mechanisms in Parkinson's disease:Targets for potential treatments显示文摘Gradual degeneration and loss of dopaminergic neurons in the substantia nigra,pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson’s disease(PD).In addition,half of the PD patients also exhibit frontostriatal-mediated executive dysfunction,including deficits in attention,short-term working memory,speed of mental processing,and impulsivity.The most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of patients.Because,these therapies neither restore the lost or degenerated dopaminergic neurons,nor prevent or delay the disease progression,the need for more effective therapeutics is critical.In this review,we provide a comprehensive overview of the current understanding of the molecular signaling pathways involved in PD,particularly within the context of how genetic and environmental factors contribute to the initiation and progression of this disease.The involvement of molecular chaperones,autophagy-lysosomal pathways,and proteasome systems in PD are also highlighted.In addition,emerging therapies,including pharmacological manipulations,surgical procedures,stem cell transplantation,gene therapy,as well as complementary,supportive and rehabilitation therapies to prevent or delay the progression of this complex disease are reviewed. | Panchanan Maiti Jayeeta Manna Gary L.Dunbar | 2017 | Translational Neurodegeneration2017，6，1： | 27 |
| 2 | High-speed colour-converting photodetector with all-inorganic CsPbBr_(3) perovskite nanocrystals for ultraviolet light communication显示文摘Optical wireless communication(OWC)using the ultra-broad spectrum of the visible-to-ultraviolet(UV)wavelength region remains a vital field of research for mitigating the saturated bandwidth of radio-frequency(RF)communication.However,the lack of an efficient UV photodetection methodology hinders the development of UV-based communication.The key technological impediment is related to the low UV-photon absorption in existing silicon photodetectors,which offer low-cost and mature platforms.To address this technology gap,we report a hybrid Sibased photodetection scheme by incorporating CsPbBr_(3) perovskite nanocrystals(NCs)with a high photoluminescence quantum yield(PLQY)and a fast photoluminescence(PL)decay time as a UV-to-visible colourconverting layer for high-speed solar-blind UV communication.The facile formation of drop-cast CsPbBr_(3) perovskite NCs leads to a high PLQY of up to ~73% and strong absorption in the UV region.With the addition of the NC layer,a nearly threefold improvement in the responsivity and an increase of ~25% in the external quantum efficiency(EQE)of the solar-blind region compared to a commercial silicon-based photodetector were observed.Moreover,timeresolved photoluminescence measurements demonstrated a decay time of 4.5 ns under a 372-nm UV excitation source,thus elucidating the potential of this layer as a fast colour-converting layer.A high data rate of up to 34 Mbps in solar-blind communication was achieved using the hybrid CsPbBr_(3)-silicon photodetection scheme in conjunction with a 278-nm UVC light-emitting diode(LED).These findings demonstrate the feasibility of an integrated high-speed photoreceiver design of a composition-tuneable perovskite-based phosphor and a low-cost silicon-based photodetector for UV communication. | Chun Hong Kang Ibrahim Dursun Guangyu Liu Lutfan Sinatra Xiaobin Sun Meiwei Kong Jun Pan Partha Maity Ee-Ning Ooi Tien Khee Ng Omar F.Mohammed Osman M.Bakr Boon S.Ooi | 2019 | Light(Science & Applications)2019，8，1： | 14 |
| 3 | Evaluation of remediation process with soapberry derived saponin for removal of heavy metals from contaminated soils in Hai-Pu, Taiwan显示文摘The use of a biodegradable natural plant-based surfactant extracted from soapberry is proposed for the remediation of Ni,Cr and Mn from industrial soil site in Hai-Pu,Taiwan.Batch experiments were performed under variation of fundamental factors(saponin concentration,pH,and incubation time) for metal remediation.Removal of Ni and Mn were increased with increasing saponin concentration(0.015-0.150 g/L),whereas the removal of Cr was increased upto 0.075 g/L saponin.The Ni,Cr and Mn were removed significantly(p ≤ 0.05) at near to the neutral and slightly acidic(pH 5 to 8) conditions.Removal efficiency of Ni(99%) from the soil was found to be greater than that of Cr(73%) or Mn(25%) in the presence of saponin at a concentration of 0.150 g/L at pH 5.The removal percentage increased with incubation time where the removal of Ni was faster than that of Cr and Mn.The result indicates the feasibility of eco-friendly removal of heavy metal(Ni,Cr and Mn) from industrial soil by soil washing process in presence of plant derived saponin. | Jyoti Prakash Maity Yuh Ming Huang Cheng-Wei Fan Chien-Cheng Chen Chun-Yi Li Chun-Mei Hsu Young-Fo Chang Ching-I Wu Chen-Yen Chen Jiin-Shuh Jean | 2013 | Journal of Environmental Sciences2013，25，6： | 11 |
| 4 | Controlled drug delivery vehicles for cancer treatment andtheir performance显示文摘Although conventional chemotherapy has been successful to some extent,the main drawbacks of chemotherapy are its poor bioavailability,high-dose requirements,adverse side effects,low therapeutic indices,development of multiple drug resistance,and non-specific targeting.The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects.In this review,we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy,emphasizing challenges in cancer treatments. | Sudipta Senapati Arun Kumar Mahanta Sunil Kumar Pralay Maiti | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 9 |
| 5 | Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles显示文摘The application of nanomedicines is increasing rapidly with the promise of targeted and efficient drug delivery.Nanomedicines address the shortcomings of conventional therapy,as evidenced by several preclinical and clinical investigations indicating site-specific drug delivery,reduced side effects,and better treatment outcome.The development of suitable and biocompatible drug delivery vehicles is a prerequisite that has been successfully achieved by using simple and functionalized liposomes,nanoparticles,hydrogels,micelles,dendrimers,and mesoporous particles.A variety of drug delivery vehicles have been established for the targeted and controlled delivery of therapeutic agents in a wide range of chronic diseases,such as diabetes,cancer,atherosclerosis,myocardial ischemia,asthma,pulmonary tuberculosis,Parkinson’s disease,and Alzheimer’s disease.After successful outcomes in preclinical and clinical trials,many of these drugs have been marketed for human use,such as Abraxane®,Caelyx®,Mepact®,Myocet®,Emend®,and Rapamune®.Apart from drugs/compounds,novel therapeutic agents,such as peptides,nucleic acids(DNA and RNA),and genes have also shown potential to be used as nanomedicines for the treatment of several chronic ailments.However,a large number of extensive clinical trials are still needed to ensure the short-term and long-term effects of nanomedicines in humans.This review discusses the advantages of various drug delivery vehicles for better understanding of their utility in terms of current medical needs.Furthermore,the application of a wide range of nanomedicines is also described in the context of major chronic diseases. | Akhand Pratap Singh Arpan Biswas Aparna Shukla Pralay Maiti | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 6 | Abrus agglutinin suppresses human hepatocellular carcinoma in vitro and in vivo by inducing caspase- mediated cell death显示文摘 | Subhadip MUKHOPADHYAY Prashanta Kumar PANDA Durgesh Nandini DAS Niharika SINHA Birendra BEHERA Tapas Kumar MAITI Sujit Kumar BHUTIA | 2014 | Acta Pharmacologica Sinica2014，35，6： | 5 |
| 7 | Isothermal Grain Growth of Austenite in Hypoeutectoid and Hypereutectoid Plain Carbon Steels显示文摘Grain growth kinetics of austenite in a hypoeutectoid steel(containing carbon of 0.35%)at 920 ℃ and in a hypereutectoid steel(containing carbon of 1%)at 980 ℃ for holding time ranging from 1 h to 6 h was investigated.The hypoeutectoid steel exhibited normal grain growth without solute drag hindrance with a time exponent(0.51)close to the theoretical value(0.5).However,the grain growth of austenite in the hypereutectoid steel held up to 3 h was extremely slow,characterizing by a low value of time exponent(0.08).Thereafter,a breakaway occurred and the grain growth in the hypereutectoid steel held from 3 h to 6 h progressed normally with a time exponent(0.52)close to the theoretical value(0.5). | Joydeep Maity Dipak Kumar Mondal | 2010 | Journal of Iron and Steel Research(International)2010，17，7： | 5 |
| 8 | Hypobaric-hypoxia Induces Alteration in Microbes and Microbes-associated Enzyme Profile in Rat Colonic Samples显示文摘Present study deals with the straight impact of hypobaric hypoxia on the quantity and composition of some predominant fecal microflora and its functional aspects.For that,isolated fecal contents of rat were exposed to two different simulated | Chiranjit MAITY Atanu ADAK Kuntal GHOSH Bikas R PATI Keshab C MONDAL | 2013 | Biomedical and Environmental Sciences2013，26，10： | 4 |
| 9 | Leads from Indian medicinal plants with hypoglycemic potentials显示文摘 | Pulok K. Mukherjee Kuntal Maiti Kakali Mukherjee Peter J. Houghton | 2006 | Journal of Ethnopharmacology2006，，1： | 4 |
| 10 | Multi-item fuzzy inventory model for deteriorating items in multi-outlet under single management显示文摘Multi-item inventory model with stock-dependent demand is developed in fuzzy environment.Items are deteriorated in constant rate and are sold from different outlets in the city under single management.Due to the impreciseness of different parameters,objectives as well as constraints are imprecise in nature.As optimization of fuzzy objectives as well as fuzzy constraints are not well defined,the model is formulated as a multi-objective chance constrained programming problem where optimistic/pessimistic return of the objectives with some degree of possibility/necessity are optimized and constraints are satisfied with some degree of necessity.The model is solved via Multi-Objective Genetic Algorithm(MOGA)when crisp equivalent of the problem is available.In other cases,fuzzy simulation process is proposed to check the constraints as well as to determine the optimistic/pessimistic return of the objectives.The model is illustrated with some numerical examples. | Ajoy Kumar Maiti | 2020 | Journal of Management Analytics2020，7，1： | 4 |
| 11 | Analysis of some critical aspects in hot machining of Ti-5553 superalloy: Experimental and FE analysis显示文摘In this study, a newly developed titanium superalloy, i.e., the Ti-5553 alloy has used for hot machining. This material replaced Ti-grade-5 alloy in the application of aerospace, automobile, and biomedical sector. However, similar to Ti-grade-5 alloy, the Ti-5553 alloy has a low thermal conductivity which makes it difficult-to-cut material categories hence, high tool wear, cutting force and bad surface finish. Hot machining of Ti-5553 has been studied at different machining condition (room and hot) using Deform-2D finite element analysis. The result from the simulation test was compared with the experimental value and reduction of cutting and thrust forces was observed. The experiment was carried out with the same input parameters as simulation, and good coherence between them observed. Additionally, cutting zone temperature, effective stress, etc. for both room and elevated the temperature are also discussed. | Asit Kumar Parida Kalipada Maity | 2019 | Defence Technology(防务技术)2019，15，3： | 3 |
| 12 | 三轴矢量无人飞行器的创新设计与研究显示文摘为探索三轴及以上矢量动力无人飞行器的研究,基于多轴旋翼和二轴矢量飞行器的飞行原理基础,创新出一种不完全矢量动力驱动模式的三轴矢量无人飞行器。根据设计的尾部矢量动力系统,构建了机体三维模型,并实现了起降、俯仰、横滚、偏航等四种飞行姿态的平稳变换。通过对飞行器机臂连接管件的承载应力与变形分析:该部件正常工况下的最大承受应力为2.338e-1 MPa,小于使用材料的屈服应力;该部件最大形变量为3.714e-3 mm,材料变形远小于最大变形许可范围值。此外,又对飞行器PID控制策略及其稳定功能进行了可视化处理,依据图像调整飞行参数使得Strength数值保持在1.00附近且波动可控。外场飞行航测表明,三轴矢量飞行器能达到稳定飞行及摄像等预期目的。文中对三轴矢量无人飞行器的设计分析有助于矢量无人飞行器的结构创新及其工程应用研究。 | 胡瑞 许春霞 熊乐 盛敬 胡月 Roger Lewis Raman Maiti | 2020 | 机械设计与研究2020，36，5： | 3 |
| 13 | Development of a mass model in estimating weight-wise particle size distribution using digital image processing显示文摘Particle size distribution of coarse aggregates through mechanical sieving gives results in terms of cumulative mass percent. But digital image processing generated size distribution of particles, while being fast and accurate, is often expressed in terms of area function or number of particles. In this paper, a mass model is developed which converts the image obtained size distribution to mass-wise distribution, making it readily comparable to mechanical sieving data. The concept of weight/particle ratio is introduced for mass reconstruction from 2D images of particle aggregates. Using this mass model, the effects of several particle shape parameters(such as major axis, minor axis, and equivalent diameter) on sieve-size of the particles is studied. It is shown that the sieve-size of a particle strongly depend upon the shape parameters, 91% of its variation being explained by major axis, minor axis, bounding box length and equivalent diameter. Furthermore, minor axis gives an overall accurate estimate of particle sieve-size, error in mean size(D-50) being just 0.4%. However, sieve-size of smaller particles(<20 mm) strongly depends upon the length of the smaller arm of the bounding box enclosing them and sieve-sizes of larger particles(>20 mm) are highly correlated to their equivalent diameters. Multiple linear regression analysis has been used to generate overall mass-wise particle size distribution, considering the influences of all these shape parameters on particle sieve-size. Multiple linear regression generated overall mass-wise particle size distribution shows a strong correlation with sieve generated data. The adjusted R-square value of the regression analysis is found to be 99 percent(w.r.t cumulative frequency). The method proposed in this paper provides a time-efficient way of producing accurate(up to 99%) mass-wise PSD using digital image processing and it can be used effectively to replace the mechanical sieving. | Maiti Abhik Chakravarty Debashish Biswas Kousik Halder Arpan | 2017 | International Journal of Mining Science and Technology2017，27，3： | 3 |
| 14 | Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin显示文摘 | K.Indira Priyadarsini Dilip K. Maity G.H. Naik M.Sudheer Kumar M.K. Unnikrishnan J.G. Satav Hari Mohan | 2003 | Free Radical Biology and Medicine2003，，： | 2 |
| 15 | Kernel fuzzy c-means clustering on energy detection based cooperative spectrum sensing显示文摘 | Anal Paul Santi P. Maity | 2016 | Digital Communications and Networks2016，2，4： | 2 |
| 16 | 细菌产生的纤维素酶(综述)(续2)显示文摘本期主要介绍纤维素酶在细菌体系中的作用方式、细菌共培养以及纤维素酶基因在异源宿主中的克隆与表达。 | 严鸿林 唐彩琰 Sangrila Sadhu1 Tushar Kanti Maiti | 2018 | 国外畜牧学(猪与禽)2018，38，12： | 2 |
| 17 | Estimation of carbon sequestration in reclaimed coalmine degraded land dominated by Albizia lebbeck, Dalbergia sissoo and Bambusa arundinacea plantation: a case study from Jharia Coalfields, India显示文摘 | Rimi Das Subodh Kumar Maiti | 2016 | International Journal of Coal Science & Technology2016，3，2： | 2 |
| 18 | Stability analysis of combined project of fish, broiler and ducks: Dynamical system in imprecise environment显示文摘 | A. De K. Maity M. Maiti | 2015 | International Journal of Biomathematics2015，8，5： | 2 |
| 19 | Removal of Cu, Pb and Zn by foam fractionation and a soil washing process from contaminated industrial soils using soapberry-derived saponin: A comparative effectiveness assessment显示文摘 | Jyoti Prakash Maity Yuh Ming Huang Chun-Mei Hsu Ching-I Wu Chien-Cheng Chen Chun-Yi Li Jiin-Shuh Jean Young-Fo Chang Chen-Yen Chen | 2013 | Chemosphere2013，，10： | 2 |
| 20 | 信号调制系统实现角位移测量(英文)显示文摘采用基于定时器LM555的非稳态多谐振荡器和通用频数转换设计了一种变面积式电容传感器信号调制系统用于角位移测量。变面积式电容器连接在基于定时器的非稳态电路内,其角位移的变化引起电容的变化,进而引起定时器电路输出时间周期的变化。定时器电路输出波形的时间周期与电容呈线性关系,因而与角位移也是线性关系。定时器输出经通用频数转换器进一步处理后可用于测量。实验结果显示,时间周期与角位移在0-180°范围内呈线性关系,将不确定度与平均时间周期相关联,即为平均标准差,亦称为标准误差,其值为±0.023μs。该测量系统使用简单,可用于电子和工业仪器中。 | Sumitesh Majumder T K Maiti | 2019 | Journal of Measurement Science and Instrumentation2019，10，1： | 2 |
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