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| 1 | Gα_s signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling显示文摘How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases. | Ruoshi Xu Sanjoy Kumar Khan Taifeng Zhou Bo Gao Yaxing Zhou Xuedong Zhou Yingzi Yang | 2018 | Bone Research2018，6，4： | 7 |
| 2 | Rapid Detection of Wheat Blast Pathogen Magnaporthe oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Technology显示文摘Wheat blast,caused by the fungus Magnaporthe oryzae Triticum(MoT)pathotype,is a devastating disease persistent in South America and Bangladesh.Since MoT generally fails to cause visual symptoms in wheat until the heading stage when the infection would have advanced,disease control by fungicide application solely based on the detection of visual symptoms is ineffective.To develop an accurate and sensitive method to detect MoT at the seedling and vegetative stages for disease control,we sequenced the genomes of two MoT isolates from Brazil and identified two DNA fragments,MoT-6098 and MoT-6099,that are present in the MoT genome but not in the genome of the rice-infecting Magnaporthe oryzae Oryzae(MoO)pathotype.Using polymerase chain reaction(PCR),we confirmed the specificity of the two markers in 53 MoT and MoO isolates from South America and Bangladesh.To test the efficiency of the two markers,we first established a loop-mediated isothermal amplification(LAMP)method to detect MoT at isothermal conditions,without the use of a PCR machine.Following this,we used the Cas12a protein and guide RNAs(gRNAs)to target the MoT-6098 and MoT-6099 sequences.The activated Cas12a showed indiscriminate single-stranded deoxyribonuclease(ssDNase)activity.We then combined targetdependent Cas12a ssDNase activation with recombinase polymerase amplification(RPA)and nucleic acid lateral flow immunoassay(NALFIA)to develop a method that accurately,sensitively,and cost-effectively detects MoT-specific DNA sequences in infected wheat plants.This novel technique can be easily adapted for the rapid detection of wheat blast and other important plant diseases in the field. | Houxiang Kang Ye Peng Kangyu Hua Yufei Deng Maria Bellizzi Dipali Rani Gupta Nur Uddin Mahmud Alfredo S.Urashima Sanjoy Kumar Paul Gary Peterson Yilin Zhou Xueping Zhou Md Tofazzal Islam Guo-Liang Wang | 2021 | Engineering2021，7，9： | 4 |
| 3 | Adaptive integral higher order sliding mode controller for uncertain systems显示文摘This paper proposes an adaptive integral higher order sliding mode (HOSM) controller for uncertain systems. Instead of a regular control input, the derivative of the control input is used in the proposed control law. The discontinuous sign function in the controller is made to act on the time derivative of the control input. The actual control signal obtained by integrating the derivative control signal is smooth and chattering free. The adaptive tuning law used in the proposed controller eliminates the need of prior knowledge about the upper bound of the system uncertainties. Stability and robustness of the proposed controller are proved by using the classical Lyapunov criterion. Simulation results demonstrate the advantages of the proposed control scheme. | Sanjoy MONDAL Chitralekha MAHANTA | 2013 | 控制理论与应用(英文版)2013，11，1： | 3 |
| 4 | A simple,efficient and green procedure for Michael addition catalyzed by [C_4dabco]OH ionic liquid显示文摘A dabco-based basic ionic liquid,1-butyl-4-aza-1-azaniabicyclo[2.2.2]octane hydroxide,has been developed as a catalyst for a convenient and rapid method for the Michael addition of active methylene compounds to a b-unsaturated carboxylic esters and nitriles.The method is very simple,and the yields are very high.The catalyst can be recycled several times without much loss of activity. | Sanjoy Keithellakpam Warjeet S.Laitonjam | 2014 | Chinese Chemical Letters2014，25，5： | 3 |
| 5 | Review of application of mass spectrometry for analyses of anterior eye proteome显示文摘Proteins have important functional roles in the body, which can be altered in disease states. The eye is a complex organ rich in proteins; in particular, the anterior eye is very sophisticated in function and is most commonly involved in ophthalmic diseases. Proteomics, the large scale study of proteins, has greatly impacted our knowledge and understanding of gene function in the post-genomic period. The most significant breakthrough in proteomics has been mass spectrometric identification of proteins, which extends analysis far beyond the mere display of proteins that classical techniques provide. Mass spectrometry functions as a 'mass analyzer' which simplifies the identification and quantification of proteins extracted from biological tissue. Mass spectrometric analysis of the anterior eye proteome provides a differential display for protein comparison of normal and diseased tissue. In this article wepresent the key proteomic findings in the recent literature related to the cornea, aqueous humor, trabecular meshwork, iris, ciliary body and lens. Through this we identified unique proteins specific to diseases related to the anterior eye. | Sherif Elsobky Ashley M Crane Michael Margolis Teresia A Carreon Sanjoy K Bhattacharya | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 6 | WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation显示文摘 | James X. Gray Lyle McMillen Peter Mollee Sanjoy Paul Steven Lane Robert Bird Devinder Gill Russell Saal Paula Marlton | 2011 | Leukemia Research2011，，4： | 2 |
| 7 | mLBOA:A Modified Butterfly Optimization Algorithm with Lagrange Interpolation for Global Optimization显示文摘Though the Butterfly Bptimization Algorithm(BOA)has already proved its effectiveness as a robust optimization algorithm,it has certain disadvantages.So,a new variant of BOA,namely mLBOA,is proposed here to improve its performance.The proposed algorithm employs a self-adaptive parameter setting,Lagrange interpolation formula,and a new local search strategy embedded with Levy flight search to enhance its searching ability to make a better trade-off between exploration and exploitation.Also,the fragrance generation scheme of BOA is modified,which leads for exploring the domain effectively for better searching.To evaluate the performance,it has been applied to solve the IEEE CEC 2017 benchmark suite.The results have been compared to that of six state-of-the-art algorithms and five BOA variants.Moreover,various statistical tests,such as the Friedman rank test,Wilcoxon rank test,convergence analysis,and complexity analysis,have been conducted to justify the rank,significance,and complexity of the proposed mLBOA.Finally,the mLBOA has been applied to solve three real-world engineering design problems.From all the analyses,it has been found that the proposed mLBOA is a competitive algorithm compared to other popular state-of-the-art algorithms and BOA variants. | Sushmita Sharma Sanjoy Chakraborty Apu Kumar Saha Sukanta Nama Saroj Kumar Sahoo | 2022 | Journal of Bionic Engineering2022，19，4： | 2 |
| 8 | Dynamic risk factors associated with non‐severe hypoglycemia in patients treated with insulin glargine or exenatide once weekly 与每日一次使用甘精胰岛素或者每周一次使用艾塞那肽治疗的患者出现非严重低血糖相关的动态危险因素显示文摘 | Sanjoy K. Paul David Maggs Kerenaftali Klein Jennie H. Best | 2015 | Journal of Diabetes2015，，： | 2 |
| 9 | Safety and immunogenicity of human papillomavirus-16/18 AS04-adjuvanted vaccine in healthy Chinese females aged 15 to 45 years:a phase Ⅰ trial显示文摘Globally,about 70% of cervical cancers are associated with human papillomavirus (HPV)-16 or HPV-18 infection.A meta-analysis of epidemiologic studies in China showed that HPV was present in 98% of cervical cancer samples.The HPV-16/18 AS04-adjuvanted vaccine Cervarix has shown a high level of protection against HPV-16/18 infections and associated cervical lesions.This phase Ⅰ trial (NCT00549900) assessed the safety,tolerability,and immunogenicity of the vaccine in Chinese.Thirty healthy Chinese females,aged 15 to 45 years with a median age of 29.5 years,received three doses of Cervarix in Months 0,1,and 6.Safety was assessed via recording solicited local and systemic symptoms within 7 days and unsolicited symptoms within 30 days after each vaccination.Serious adverse events,new onset of chronic diseases,and other medically significant conditions were recorded throughout this trial.As an exploratory objective,HPV-16/18 antibody titers were determined by enzyme-linked immunosorbent assay in serum samples collected in Months 0 and 7.Pain at the injection site was the most frequently reported local symptom.Two subjects reported medically significant adverse events.Both cases were assessed as unrelated to vaccination by the investigator.In Month 7,100% seroconversion was observed for both anti-HPV-16 and anti-HPV-18 with high geometric mean antibody titers.HPV-16/18 AS04-adjuvanted vaccine,evaluated for the first time in Chinese females,was generally well tolerated and immunogenic,as previously shown in global studies. | Feng-Cai Zhu Chang-Gui Li Hong-Xing Pan Yi-Ju Zhang Dan Bi Hai-Wen Tang Sanjoy Datta | 2011 | Chinese Journal of Cancer2011，30，8： | 2 |
| 10 | Reporting Standards for Endovascular Treatment of Lower Extremity Deep Vein Thrombosis显示文摘 | Suresh Vedantham Clement J. Grassi Hector Ferral Nilesh H. Patel Patricia E. Thorpe Vittorio P. Antonacci Bertrand M. Janne d’Othée Lawrence V. Hofmann John F. Cardella Sanjoy Kundu Curtis A. Lewis Marc S. Schwartzberg Robert J. Min David Sacks | 2009 | Journal of Vascular and Interventional Radiology2009，，7： | 1 |
| 11 | Effects of nitrophenols on acetate utilizing methanogenic systems显示文摘 | Mohammad R Haghighi Podeh Sanjoy K Bhattacharya Mingbo Qu | 1995 | Wat Res1995，29，2： | 1 |
| 12 | Kinetics of formation and dissociation of the ternary complex ion (pentane-2,4-dionato)(nitrilotriacetato)chromate(Ⅲ) in aqueous media显示文摘 | Sanjoy K B Rupendranath B | | Inorg Chem0，16，24： | 1 |
| 13 | Toxicity and degradability of nitrophenols in anaerobic systems 显示文摘 | Vikas Uberoi Sanjoy K Bhattacharya | 1997 | Water Environ Res1997，69，2： | 1 |
| 14 | 10-year follow-up of intensive glucose control in type 2 diabetes显示文摘 | Rury RH Sanjoy KP David RM | 2008 | N Engl J Med2008，359，15： | 1 |
| 15 | Dysregulation of EGF family of growth fact-ors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocystwith the luminal epithelium correlates with implantation failure in LIF-deficient mice 显示文摘 | Haengseok S Hyunjung L Sanjoy KD | 2000 | Mol Endoerinol2000，14，8： | 1 |
| 16 | central venous disease in hemodialysis patients: prevalence, etiology and treatment显示文摘 | Sanjoy Kundu | 2010 | The Journal of Vascular Access2010，11，1： | 1 |
| 17 | Scheduling for overload in real time system显示文摘 | Sanjoy K B Jayant R H | 1997 | IEEE Transaction1997，46，9： | 1 |
| 18 | Toxic Effects Of Cadmiun On Methanogenie Systems 显示文摘 | Sanjoy K Bhattaeharya Richard L | 1995 | Water Resrch1995，29，10： | 1 |
| 19 | Optimal control of effort of a stage structured prey-predator fishery model with harvesting显示文摘 | Chakraborty Kunal Das Sanjoy Kar T K | 2011 | Nonlinear Analysis:Real World Applications2011，12，6： | 1 |
| 20 | Use of response surface methodology for optimizing process parameters for the production ofα-amylase by Aspergillus oryzae显示文摘 | Febe Francis Abdulhameed Sabu K Madhavan Nampoothiri Sumitra Ramachandran Sanjoy Ghosh George Szakacs Ashok Pandey | 2002 | Biochemical Engineering Journal2002，15，2： | 1 |
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