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| 1 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 2 | Significance of serum and hepatic micro RNA ‐122 levels in patients with non‐alcoholic fatty liver disease显示文摘 | Hisamitsu Miyaaki Tatsuki Ichikawa Yasuhiro Kamo Naota Taura Takuya Honda Hidetaka Shibata Maddalena Milazzo Francesca Fornari Laura Gramantieri Luigi Bolondi Kazuhiko Nakao | 2014 | Liver Int2014，，7： | 4 |
| 3 | Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis显示文摘 | Kojiro Taura Samuele De Minicis Ekihiro Seki Etsuro Hatano Keiko Iwaisako Christoph H. Osterreicher Yuzo Kodama Kouichi Miura Iwao Ikai Shinji Uemoto David A. Brenner | 2008 | Gastroenterology2008，，5： | 3 |
| 4 | Prognostic Index for Patients with Hepatocellular Carcinoma Combined with Tumor Thrombosis in the Major Portal Vein显示文摘 | Iwao Ikai Etsuro Hatano Suguru Hasegawa Hideaki Fujii Kojiro Taura Naoki Uyama Yasuyuki Shimahara | 2006 | Journal of the American College of Surgeons2006，，3： | 2 |
| 5 | Clinical characteristics of hepatocellular carcinoma in elderly patients显示文摘 | Takuya Honda Hisamitsu Miyaaki Tatsuki Ichikawa Naota Taura Satoshi Miuma Hidetaka Shibata Hajime Isomoto Fuminao Takeshima Kazuhiko Nakao | 2011 | Oncology Letters2011，，5： | 2 |
| 6 | An observation of wear process of bi-layered molecular films with acoustic emission-relationship between AE effective value and friction coefficient显示文摘 | Taura Hiroo Kawaguchi Masahiro Kaneko Satoru | 2005 | Toraibarojisuto2005，50，4： | 1 |
| 7 | Activation of the receptor for advanced glycation end products triggers a p21 (ras) -dependent mitogen-activated protein kinase pathway regulated by oxidant stress显示文摘 | Lander HM Tauras JM Ogiste JS | 1997 | J Biol Chem1997，272，17： | 1 |
| 8 | Activation of the receptor for advanced glycation end products triggers a p21 (ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress显示文摘 | Laneler HM Tauras JM Ogiste JS | 1997 | Biol Chem1997，272，17： | 1 |
| 9 | NX-PVKA levels before and after hepatectomy of hepatocellular carcinoma as predictors of patient survival:a preliminary evaluation of an improved assay for PIVKA-Ⅱ显示文摘 | Nanashima A Abo T Taura N | 2013 | Anticancer Res2013，33，6： | 1 |
| 10 | Primary malignant lymphoma of the maxillary sinus: CT and MRI显示文摘 | M. Yasumoto S. Taura H. Shibuya M. Honda | 2000 | Neuroradiology2000，，4： | 1 |
| 11 | Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36,the type B scavenger receptor,through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma显示文摘 | Han J Hajjar DP Tauras JM | 2000 | J Biol Chem2000，275，： | 1 |
| 12 | CHOP deficiency attenuatescholestasis-induced liver fibrosis by reduction of hepatocyteinjury显示文摘 | Tamaki N Hatano E Taura K | 2008 | Am J Physiol Gastrointest Liver Physiol2008，294，2： | 1 |
| 13 | Diffuse liver melastasis of small cell lung eaneer causing marked hepatomegaly and fulmi- nant hepalie failure 显示文摘 | Miyaaki H Iehikawa T Taura N | 2010 | Intern Med2010，49，14： | 1 |
| 14 | Radial-motion assisted command shapers for nonlinear tower crane rotational slewing 显示文摘 | SINGHOSE W KAMOI T TAURA A | 2010 | Control Engineering Practice2010，18，5： | 1 |
| 15 | Severe portopulmonary hypertension after liver transplantation in a patient with preexisting hepatopulmonary syndrome 显示文摘 | Martinez-Palli G Barbera JA Taura P | 1999 | J Hepatol1999，31，6： | 1 |
| 16 | Branched‐chain amino acid deficiency stabilizes insulin‐induced vascular endothelial growth factor mRNA in hepatocellular carcinoma cells显示文摘 | Satoshi Miuma Tatsuki Ichikawa Kazuhiko Arima Shigeyuki Takeshita Toru Muraoka Toshihisa Matsuzaki Masashi Ootani Hidetaka Shibata Motohisa Akiyama Eisuke Ozawa Hisamitsu Miyaaki Naota Taura Fuminao Takeshima Kazuhiko Nakao | 2012 | J Cell Biochem2012，，10： | 1 |
| 17 | Induction and isolation of vascular cells from human induced pluripotent stem cells: brief report显示文摘 | Taura D Sone M Homma K | 2009 | Arterioscl Throm Vas2009，29，7： | 1 |
| 18 | Prevalence of type 2 diabetes mellitus in Japanese patients with hepatocellularcarcinoma显示文摘 | Naota Taura Tatsuki Ichikawa Hisamitsu Miyaaki Hiroshi Yatsuhashi Hiromi Ishibashi Kazuhiko Nakao | 2011 | Experimental and Therapeutic Medicine2011，，1： | 1 |
| 19 | Heterogeneity of hepatic parenchyma enhancement on computed tomography during arterial portography:quantitative analysis of correlation with severity of hepatic fibrosis显示文摘 | Taura T Nakamura K Takashina S | 2001 | J Hepatoi Res2001，20，2： | 1 |
| 20 | Angiotensinconverting-enzyme 2 inhibits liver fibrosis in mice显示文摘 | Osterreicher CH Taura K De Minicis S | 2009 | Hepatology2009，50，3： | 1 |
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