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| 1 | Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas显示文摘BACKGROUND: Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, and angiogenesis and induce apoptosis. We examined maspin expression immunohistochemically and assessed its significance in intraductal papillary mucinous neoplasm (IPMN) of the pancreas. METHODS: We examined 39 surgically resected specimens of IPMN that included 17 adenomas (IPMAs), 5 borderline tumors (IPMBs), 4 non-invasive carcinomas (non-invasive IPMCs), and 13 invasive carcinomas (invasive IPMCs). Immunostaining was performed according to the EnVision ChemMate method. The degree of maspin expression was scored and assessed according to the percentage and staining intensity of positive cells. RESULTS: Maspin expression was minimal in normal pancreatic duct epithelium, whereas in IPMNs, maspin was expressed in neoplasms of all stages. Maspin expression increased with increasing grade from IPMAs, IPMBs, to non-invasive IPMCs but decreased significantly in invasive IPMCs. No specific association between maspin expression and mucin type was found. Analysis of maspin expression with respect to clinicopathologic factors in cases of invasive IPMC revealed a greater extent of invasion in cases of low maspin expression and significantly fewer apoptotic cells in the tumor.CONCLUSIONS: Maspin was expressed at high levels in IPMNs at various stages from adenoma to invasive carcinoma, and our results suggest that maspin may be involved in the occurrence and progression of IPMN. In addition, our data suggest that the apoptosis-inducing action of maspin suppresses invasion and progression of IPMN. | Kyoko Kashima Nobuyuki Ohike Seishiro Mukai Masashi Sato Manabu Takahashi Toshio Morohoshi | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 9 |
| 2 | SSJD14101300023292显示文摘 | Shinya Sugimoto Hidetaka Yamada Masazumi Takahashi Yuichi Morohoshi Naotaka Yamaguchi Yuya Tsunoda Hiroyuki Hayashi Haruhiko Sugimura Hirokazu Komatsu | 2014 | Gastric Cancer2014，，4： | 4 |
| 3 | Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization显示文摘 | Kei Morohoshi Nishal Patel Masaharu Ohbayashi Victor Chong Hans E. Grossniklaus Alan C. Bird Santa J. Ono | 2011 | Experimental and Molecular Pathology2011，，1： | 1 |
| 4 | Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in pressure ulcer infection in rats显示文摘 | Nakagami G Morohoshi T Ikeda T | 2011 | Wound Repair Régen2011，，02： | 1 |
| 5 | Critical role of IgE-dependent mast cell activation in a murine model of allergic conjunctivitis显示文摘 | Fukuda K Ohbayashi M Morohoshi K | 2009 | J Allergy Clin Immunol2009，124，4： | 1 |
| 6 | Prognostic significance of the maspin tumor suppressor gene in pulmonary adenocarcinoma显示文摘 | Masanao Nakashima Nobuyuki Ohike Koichi Nagasaki Mitsuru Adachi Toshio Morohoshi | 2004 | Journal of Cancer Research and Clinical Oncology2004，，8： | 1 |
| 7 | Inhibition of quorum sensing in Serratia marcescens AS-1 by synthetic analogs of N-acylhomoserine lactone显示文摘 | MOROHOSHI T SHIONO T TAKIDOUCHI K | 2007 | Appl Environ Microbiol2007，73，： | 1 |
| 8 | Influences of 4-meta/ MMA-TBB adhesive resin on osteodentiangenesis of transsplanted rabbit dental pulp in vivo: and electronmicroscopic studies显示文摘 | Morohoshi Y Inoue T Shimono M | 1999 | Bull Tokyo Dent Coil1999，40，3： | 1 |
| 9 | Exocrine pancreatic tumors andtheir histological classification: a study based on 167 autopsy and 97 surgical cases显示文摘 | Morohoshi T Held G Kloppel G | 1983 | Histopathology1983，7，： | 1 |
| 10 | Fundamental study of adhesion of ice to cooling solid surface (Discussion on influence of copper oxide layer on ice adhesion force) 显示文摘 | MATSUMOTO K MOROHOSHI M TERAOKA Y | 2009 | International Journal of Refrigeration2009，32，6： | 1 |
| 11 | Application of average flow model to thin film gas lubrication 显示文摘 | Makino T Morohoshi S Taniguchi S | 1993 | ASME Journal of Tribology1993，115，1： | 1 |
| 12 | A germ cell-specific gene of the ARGONAUTE family is essential for theprogression of premeiotic mitosis and meiosis during sporogenesisin rice显示文摘 | Nonomura K Morohoshi A Nakano M | 2007 | Plant Cell2007，19，8： | 1 |
| 13 | Control of gramnegative bacterial quorum sensing with cyclodextrin immobilized cellulose ether gel显示文摘 | Kato N Morohoshi T Nozawa T | 2006 | J Inclu Pheno Macro Chem2006，56，： | 1 |
| 14 | Lipopolysaccharide-inducible gene expression profile in human monocytes显示文摘 | Hashimoto S Morohoshi K Suzuki K | 2003 | Scand J Infect Dis2003，35，9： | 1 |
| 15 | A germ cell spe- cific gene of the Argonaute family is essential for the progression of premeiotic mitosis and meiosis during sporogenesis in rice显示文摘 | Nonomura K Morohoshi A Nakano M | 2007 | Plant Cell2007，19，： | 1 |
| 16 | Treatment of hyperlipid- emia with probucol suppresses the development of focal and segmengal glomerulosclersis in chronic aminonucleo side nephrosis显示文摘 | HIRANO T MOROHOSHI T | 1992 | Nephron1992，6，4： | 1 |
| 17 | Multiple endocrine neoplasia type 1 associated with spinal ependymoma显示文摘 | Uchimura I Morohoshi M | 2000 | Intern Med2000，35，： | 1 |
| 18 | Immunocytochemiacal markers of uncommon pancreatic tumor:acinar cell carcinoma,pancreatoblastoma,and solid cystic tumor显示文摘 | Morohoshi T Kanda M Horie A | 1987 | Cancer1987，58，： | 1 |
| 19 | Contribution of quorum sensing to the virulence of Pseudomeonas aeruginosa in pressure ulcer in- fection in rats显示文摘 | Nakagami G Morohoshi T Ikeda T | 2011 | Wound Repair Regen2011，19，2： | 1 |
| 20 | AiiM, a novel class of N-acylhomoserine lactonase from the leaf-associated bacterium Microbacterium testaceum 显示文摘 | Wang W Z Morohoshi T Ikenoya M | 2010 | Applied and Environmental Microbiology2010，76，： | 1 |
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