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| 1 | 周期素A过表达诱导S期细胞凋亡的研究显示文摘目的 探讨细胞周期 S期滞留细胞凋亡的分子基础。方法 用 Westernblot法测定 L- 2和 Br1-3pr- 1两细胞株细胞周期 S期进程相关分子 Rb、周期素 A、E、CDK2、CDC2及与细胞凋亡直接相关分子 Bcl- 2和Bax的表达 ,并用组蛋白磷酸化法测定周期素 A、E、CDK2和 CDC2相关激酶的活性。结果 经 PAL A处理后 ,发生 S期细胞凋亡的 L- 2细胞与不发生 S期细胞凋亡的 Br1- 3pr- 1细胞比较 ,其周期素 A的表达明显增加 ,Bcl- 2的表达下降。但经 PAL A处理后 ,其他分子的表达和激酶活性在上述两种细胞之间无明显差异。结论 周期素 A可能是 S期检查点基因的重要候选者 ,并可能通过调节 Bcl- 2的表达来控制 S期滞留细胞凋亡的发生。 | 尹海林 Subrata Sen 杨文 杨光武 刘学旭 | 2001 | 华西医科大学学报2001，32，2： | 7 |
| 2 | Amplification /Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer显示文摘 | Sen Subrata Zhou Hongyi Zhang Ruodan | 2002 | National Cancer Institute2002，94，： | 1 |
| 3 | Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions显示文摘 | Jin Wang Pamela L. Paris Jinyun Chen Vy Ngo Hui Yao Marsha L. Frazier Ann M. Killary Chang-Gong Liu Han Liang Christian Mathy Sandhya Bondada Kimberly Kirkwood Subrata Sen | 2014 | Cancer Letters2014，，： | 1 |
| 4 | Market segments and stochastic brand choice models 显示文摘 | Blattberg Robert C Sen Subrata K | 1976 | Journal of Marketing Research1976，13，1： | 1 |
| 5 | Market segments and stochastic brand choice models 显示文摘 | Blattberg Robert C Sen Subrata K | 1976 | Journal of Marketing Research1976，，1： | 1 |
| 6 | Aurora kinase inhibitors as anticancer molecules显示文摘 | Hiroshi Katayama Subrata Sen | 2010 | BBA - Gene Regulatory Mechanisms2010，，10： | 1 |
| 7 | MicroRNA functional network in pancreatic cancer: From biology to biomarkers of disease显示文摘 | Jin Wang Subrata Sen | 2011 | Journal of Biosciences2011，，3： | 1 |
| 8 | The Firm's Management of Social Interactions显示文摘 | David Godes Dina Mayzlin Yubo Chen Sanjiv Das Chrysanthos Dellarocas Bruce Pfeiffer Barak Libai Subrata Sen Mengze Shi Peeter Ver- legh | 2005 | Marketing Letters2005，16，34： | 1 |
| 9 | American ginseng ( Panax quinquefolius ) prevents glucose-induced oxidative stress and associated endothelial abnormalities显示文摘 | Subhrojit Sen Shali Chen Biao Feng Yuexiu Wu Edmund Lui Subrata Chakrabarti | 2011 | Phytomedicine2011，，13： | 1 |
| 10 | Polymorphisms of p16, p27, p73, and MDM2 Modulate Response and Survival of Pancreatic Cancer Patients Treated with Preoperative Chemoradiation显示文摘 | Jinyun Chen MD Donghui Li PhD Ann M. Killary PhD Subrata Sen PhD Christopher I. Amos PhD Douglas B. Evans MD James L. Abbruzzese MD Marsha L. Frazier PhD | 2009 | Annals of Surgical Oncology2009，，2： | 1 |
| 11 | Social capital, knowledge acquisition, and knowledge exploitation in young technology-based finns显示文摘 | Jayati Sarkar Subrata Sarkar and Kaustay Sen | 2001 | Strategic Managemem Journal2001，22，1： | 1 |
| 12 | Recent advances in alginate based gastroretentive technologies for drug delivery applications显示文摘The efficacy of orally delivered medicines can be maximized through enhancing the gastric residence period and modifying the drug release pattern according to therapeutic need.Several technologies were investigated through recent years for increasing gastric retention of medicines.Biopolymers are one of the widely studied materials for increasing the retention of drug delivery systems in the stomach region.The biodegradability,biocompatibility and non-toxic behavior in combination with the easy fabrication technologies has made biopolymers an interesting option to pharmaceutical scientists for developing gastroretentive drug delivery systems(GRDDS).Several gastroretentive approaches are reported to be efficacious to localize the drug delivery system in the gastric region.Alginates are commonly employed polysaccharide for developing various GRDDS including low density systems,mucoadhesive systems,swellable systems,hydrogel forming systems,in situ gelling systems,raft forming systems,magnetic systems.The abundant availability from marine and bacterial sources in combination with its attractive physicochemical nature has encouraged pharmaceutical researchers to investigate its suitability in developing various drug delivery system.The mucoadhesive,hydrogel forming and raft forming behavior of alginates makes alginate suitable for GRDDS.The attractive properties of alginate makes it a useful biopolymer in the biomedical field.This review focuses on the source and chemistry of alginates and describes the applications of alginates in developing novel gastroretentive drug delivery systems. | Olivia Sen Sreejan Manna Gouranga Nandi Subrata Jana Sougata Jana | 2023 | Medicine in Novel Technology and Devices2023，，2： | 0 |
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