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| 1 | 利用生态痕迹评价自然资本的利用在瑞典及亚区的应用显示文摘利用生态痕迹(ecological pootprint)评价人类对自然资本的利用,就是将资源消耗和废弃物产生与地球的再生能力进行比较。以前基于联合国统计资料的研究已经表明,人类对自然资本的利用已经超过了全球的生物承载力(biocapacity),同时还表明人类的生态痕迹有着很大的分布尺度。本研究主要针对瑞典,我们改进了生态痕迹与生物承裁力的计算方法,并且说明了如何才能将一个国家的生态痕迹应用于区域甚至流域。本研究还首次包含了农田淋溶的植物养分吸收区和家庭用水供应区。本文描述了生态痕迹这一评价方法,与别人和我们自己以前所使用的方法进行了对比,并讨论了这一方法应用的可能性和局限性。 | Mathis Wackernagel Lillemor Lewan Carina Borgstrom Hansson 闵庆文 | 1999 | AMBIO-人类环境杂志1999，28，7： | 160 |
| 2 | 【特刊综述】肥胖男性低睾酮的发生机制、发病率及其处理显示文摘随着亚洲现代化和城市化的日益进展,肥胖流行病的未来焦点多在亚洲地区。肥胖男性常会出现低睾酮水平,但他们并不一定有可识别的下丘脑.垂体.睾丸轴(HPT)病理变化。中度肥胖主要降低总睾酮水平,这是由胰岛素抵抗相关的性激素结合球蛋白减少所致。比较严重的肥胖与游离睾酮水平降低有关,这是由下丘脑-垂体-睾丸轴的抑制所致。低睾酮本身可导致肥胖的高风险增加,产生一个恶性循环的代谢综合征。肥胖相关的低睾酮血症是一个功能状态,而非恒定状态。这种状态是可以被逆转的,但这需要持续的减肥。虽然睾酮治疗可以引起中度的脂肪减少,但肥胖本身,在没有雄激素缺乏症状的情况下,不是既定的睾酮治疗的适应症。睾酮治疗可能会导致未经治疗的睡眠呼吸暂停恶化,损害生育能力等。睾酮治疗是否增加饮食或者运动诱导的体重降低需要在充分设计的随机对照临床试验中评估。 | Mark Ng Tang Fui | 2014 | Asian Journal of Andrology2014，16，2： | 28 |
| 3 | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients显示文摘The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense debate.The start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body.This variability seems to be correlated with the presence of genetic polymorphisms.Genotyping is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given gene.However,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that medication.At present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of tacrolimus.However,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and toxicity.For these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing. | Alessio Provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 4 | Role of the endothelium in inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease.At the core of these alterations are endothelial cells,whose continual adjustments in structure and function coordinate vascular supply,immune cell emigration,and regulation of the tissue environment.Expansion of the endothelium in IBD(angiogenesis),mediated by inflammatory growth factors,cytokines and chemokines,is a hallmark of active gut disease and is closely related to disease severity.The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines,growth factors,and adhesion molecules,altering coagulant capacity,barrier function and blood cell recruitment in injury.This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions. | Walter E Cromer J Michael Mathis Daniel N Granger Ganta V Chaitanya J Steven Alexander | 2011 | World Journal of Gastroenterology2011，17，5： | 10 |
| 5 | Hematological changes during androgen deprivation therapy显示文摘雄激素剥夺治疗(ADT ) 与不利效果的过多被联系了,与多重繁殖、体的纸巾的雄激素相关性一致。一如此的纸巾是 hemopoietic 系统,并且 ADT 的最可预言的后果之一是贫血症的开发。尽管 ADT 引起的贫血症是很少严重, ADT 经常与增加的危险性被给脆弱的、老人到贫血症由于多重另外的原因。联系 ADT 的贫血症可以贡献疲劳并且减少在如此的人的生活(QoL ) 的质量,尽管这要求进一步的学习。当贫血症是在有前列腺癌症的人的死亡的一个独立风险因素时,联系 ADT 的贫血症的治疗是否改变临床上重要的结果,或治疗是否影响死亡,不被知道。导致 ADT 的贫血症的现象的了解应该在正常红血球的 normochromic 贫血症的温和情况中避免不必要的病情的检查。然而,对更多的严重贫血症的评价和治疗可以被要求。这应该在一个单个基础上被决定。与红血球生成上的 ADT 的描述得好的行动相对照,它另外的 hemopoietic 系上的效果是更少很好阐明。当现出症状之前的潜的研究在成熟为雄激素发现了角色并且区分了 neutrophils,淋巴细胞和血小板的功能时,为有收到 ADT 的前列腺癌症的人的这些调查结果的含意要求进一步的研究。 | Mathis Grossmann Jeffrey D Zajac | 2012 | Asian Journal of Andrology2012，14，2： | 9 |
| 6 | Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases显示文摘Dear Editor, Sequence-specific nucleases,including zinc-finger nucleases,meganucleases,TAL effector nucleases (TALENs),and CRISPR/ Cas systems,have been used to introduce targeted mutations in a wide range of plant species (Voytas,2013;Baltes and Voytas,2015).However,delivery of these nucleases using traditional transformation methods (e.g.,particle bombardment,Agrobacterium or protoplast transformation) may result in undesired genetic alterations due to random insertion of nucleaseencoding DNA intothe host genome. | Song Luo Jin Li Thomas J. Stoddard Nicholas J. Baltes Zachary L. Demorest Benjamin M. Clasen Andrew Coffman Adam Retterath Luc Mathis Daniel F. Voytas Feng Zhang | 2015 | Molecular Plant2015，8，9： | 7 |
| 7 | 激光诱导击穿光谱法连续测定高炉流道中的组分和温度显示文摘介绍了用于炼铁和炼钢领域过程控制的传感器。用激光诱导击穿光谱法(LIBS)连续测定高炉(BF)流道中的组分和温度,此传感器主要用于高炉流道的在线测量,监测了两次浇铸过程中元素硅、锰和碳的浓度,结果满意。 | Mathy Monfort G Vanderheyden B Tusset V | 2011 | 冶金分析2011，31，10： | 6 |
| 8 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 5 |
| 9 | Calcineurin inhibitor sparing strategies in renal transplantation, part one: Late sparing strategies显示文摘Kidney transplantation improves quality of life and reduces the risk of mortality. A majority of the success of kidney transplantation is attributable to the calcineurin inhibitors(CNIs), cyclosporine and tacrolimus, and their ability to reduce acute rejection rates. However, longterm graft survival rates have not improved over time, and although controversial, evidence does suggest a role of chronic CNI toxicity in this failure to improve outcomes. Consequently, there is interest in reducing or removing CNIs from immunosuppressive regimens in an attempt to improve outcomes. Several strategies exist to spare calcineurin inhibitors, including use of agents such as mycophenolate mofetil(MMF), mycophenolate sodium(MPS), sirolimus, everolimus or belatacept to facilitate late calcineurin inhibitor withdrawal, beyond 6 mo post-transplant; or using these agents to plan early withdrawal within 6 mo; or to avoid the CNIs all together using CNI-free regimens. Although numerous reviews have been written on this topic, practice varies significantly between centers. This review organizes thedata based on patient characteristics(i.e., the baseline immunosuppressive regimen) as a means to aid the practicing clinician in caring for their patients, by matching up their situation with the relevant literature. The current review, the first in a series of two, examines the potential of immunosuppressive agents to facilitate late CNI withdrawal beyond 6 mo post-transplant, and has demonstrated that the strongest evidence resides with MMF/MPS. MMF or MPS can be successfully introduced/maintained to facilitate late CNI withdrawal and improve renal function in the setting of graft deterioration, albeit with an increased risk of acute rejection and infection. Additional benefits may include improved blood pressure, lipid profile and serum glucose.Sirolimus has less data directly comparing CNI withdrawal to an active CNI-containing regimen, but modest improvement in short-term renal function is possible, with an increased risk of proteinuria, especially in the setting of baseline renal dysfunction and/or proteinuria. Renal outcomes may be improved when sirolimus is used in combination with MMF. Although data with everolimus is less robust, results appear similar to those observed with sirolimus. | Andrew Scott Mathis Gwen Egloff Hoytin Lee Ghin | 2014 | World Journal of Transplantation2014，4，2： | 5 |
| 10 | Diagnosis and treatment of hypogonadism in older men: proceed with caution显示文摘 | Mathis Grossmann | 2010 | Asian Journal of Andrology2010，12，6： | 4 |
| 11 | Sectoral agglomeration economies in a panel of European regions显示文摘 | Marius Brülhart Nicole A. Mathys | 2008 | Regional Science and Urban Economics2008，，4： | 4 |
| 12 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 3 |
| 13 | Maintaining biodiversity will define our long-term success显示文摘Human beings are not only a part of our planet's ecosystems,but also,they are massively overusing them.This makes ecosystem protection,including biodiversity preservation,vital for humanity's future.The speed and scale of the threat are unprecedented in human history.The long arch of evolution has been confronted with such a high level of human impact,that we are now facing the sixth mass extinction event,66 million years after the last one.This threat heightens the imperative for bold human intervention.Our paper identifies three strategies for such an intervention.First,and possibly most challenging,human demand needs to be curbed so it fits within the bounds of what Earth's ecosystems can renew.Without meeting this quantitative goal,biodiversity preservation efforts will not be able to get scaled.Second,in the transition time,we must focus on those locations and areas where most biodiversity is concentrated.Such a focus on‘hotspots’will help safeguard the largest portion of biodiversity with least effort.Third,to direct biodiversity preservation strategies,we need to much better document the existence and distribution of biodiversity around the globe.New information technologies could help with this critical effort.In conclusion,biodiversity preservation is no longer just a concern for specialized biologist but is becoming a societal necessity if humanity wants to have a stable future. | Peter Raven Mathis Wackernagel | 2020 | Plant Diversity2020，42，4： | 3 |
| 14 | Current view and perspectives in amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis(ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors such as clinical phenotype, age at onset, gender, early presence of respiratory failure, weight loss and treatment with Riluzole(the only disease-modifying drug approved for this disease). Nowadays, there is still no curative treatment for ALS: palliative care and symptomatic treatment are therefore essential components in the management of these patients. Nevertheless, the scientific knowledge in the field of ALS motor neuron degeneration is growing, with the prospect of new treatments. Based on this physiopathological knowledge, several new therapeutic targets are being studied, involving various mechanisms such as excitotoxicity, neuroinflammation, mitochondrial dysfunction, oxidative stress, RNA metabolism and other attractive concepts. Moreover, it is also important to identify reliable biomarkers that will be essential components for future therapeutic development and study design in ALS. In this review, we present the main recent advances and promising therapeutics and biomarkers in the field of ALS. | Stéphane Mathis Philippe Couratier Adrien Julian Philippe Corcia Gwendal Le Masson | 2017 | Neural Regeneration Research2017，12，2： | 3 |
| 15 | An Ex Vivo Biomechanical Evaluation of an Inflatable Bone Tamp Used in the Treatment of Compression Fracture显示文摘 | Stephen M. Belkoff John M. Mathis David C. Fenton Robert M. Scribner Mark E. Reiley Karen Talmadge | 2001 | Spine2001，，2： | 3 |
| 16 | TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients显示文摘 | Juan Carlos Garcia–Pagán Mathis Heydtmann Sebastian Raffa Aurélie Plessier Sarwa Murad Federica Fabris Giovanni Vizzini Juan Gonzales Abraldes Simon Olliff Antonio Nicolini Angelo Luca Massimo Primignani Harry L.A. Janssen Dominique Valla Elwyn Elias Jaum | 2008 | Gastroenterology2008，，3： | 3 |
| 17 | Percutaneous polymethylmethacrylate vertebroplasty in the treament of osteoporotic vertebral body compression fractures:technical aspects显示文摘 | Jense ME Evans AJ Mathis JM | 1997 | AJNR1997，18，10： | 2 |
| 18 | Allocating ecological footprints to final consumption categories with input–output analysis显示文摘 | Thomas Wiedmann Jan Minx John Barrett Mathis Wackernagel | 2005 | Ecological Economics2005，，1： | 2 |
| 19 | Biomechanical Evaluation of a New Bone Cement for Use in Vertebroplasty显示文摘 | Stephen M. Belkoff John M. Mathis Erik M. Erbe David C. Fenton | 2000 | Spine2000，，9： | 2 |
| 20 | Thermal characterization of bio-based phase changing materials in decorative wood-based panels for thermal energy storage显示文摘Decorative wood panels containing pouches of bio-based phase changing materials(PCMs) were prepared. Three different PCM mixtures were used: a blend of capric and lauric acids as well as two commercial products, Puretemp?20 and Puretemp?23(Puretemp). The panels consist of engraved Medium Density Fiberboard(MDF) filled with a plastic pouch filled with PCM. High density fiberboard(HDF) was used on top of the panels to enclose the PCM pouches. PCM mixtures were first tested by differential scanning calorimetry(DSC). Phase change temperature and total heat storage of the panels were measured for both fusion and solidification with a Dynamic Heat-Flow Meter Apparatus(DHFMA). DSC and DHFMA results were compared, allowing a better understanding of results gathered from these two techniques. DSC calibration has been revealed important when assessing PCMs. The panels present a phase change temperature and a latent heat storage suitable for buildings applications. The panel made with Puretemp?23 presented the highest energy, with 57.1 J g^(-1). Thermal cycling was conducted on the panels to investigate thermal reliability, which revealed small modifications of thermal properties for two products. For all cases, latent heat was found stable. Hygro-mechanical behavior of the panels was also evaluated as these where designed to be esthetic decorative panels. This study exposes the potential of a new type of wood-based panels loaded with PCM for thermal energy storage and brings overall knowledge about PCM products thermal characterization. | Damien Mathis Pierre Blanchet Véronic Landry Philippe Lagière | 2019 | Green Energy & Environment2019，4，1： | 2 |
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