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| 1 | In Vivo Phosphorylation Site Mapping and Functional Characterization of Arabidopsis Phototropin 1显示文摘Phototropins (phot1 和 phot2 ) 是控制优化植物的光合的效率的回答的一个范围的蓝光的受体 kinases。察觉到的光被二个黄素绑定主题调停,作为 LOV1 和 LOV2 知道,在蛋白质的 N 终端区域以内定位了。经由 LOV2 的 Photoexcitation 导致 C 终端 kinase 领域并且因而的激活受体 autophosphorylation。然而,为 Arabidopsis phototropins 的 in-vivo phosphorylation 地点的知识在阐明正在缺乏并且阻碍了进步受体 phosphorylation 的功能的意义。我们从 Arabidopsis 净化了 phot1 并且由液体层析双人脚踏车团 spectrometry 识别了受体 phosphorylation 的 in-vivo 地点。导出 Arabidopsis 的 phot1 作为色基绑黄素 mononucleotide 并且是在 LOV2 (Ser58, Ser85, Ser350,和 Ser410 ) 在上游的定位的四个主要地点的 phosphorylated。不过,结构功能分析显示 phot1 的生物活动能被归因于包括蛋白质的 LOV2-kinase 区域的一个模块化的单位。因此,包括这里识别的受体 phosphorylation 的地点, LOV2 在上游的肽区域不看起来为受体发信号重要。由对比,这些区域可能为最大化是必要的有气孔的性能和 phot1 的可能导致光的本地化。 | Stuart Sullivan Catriona E. Thomson Douglas J. Lamont Matthew A. Jones John M. Christie | 2008 | Molecular Plant2008，1，1： | 11 |
| 2 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 3 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 3 |
| 4 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 5 | Structure of tumor necrosis factor显示文摘 | Jones E Y Stuart D I Walker N P C | 1989 | Nature1989，338，： | 1 |
| 6 | Electrophysiology and pathology evaluation of the Yucatan pig as a non-rodent animal model for regulatory and mechanistic toxicology studies 显示文摘 | Jones RD Stuart BP Greufe NP | 1999 | Lab Anim1999，4，： | 1 |
| 7 | Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer 显示文摘 | Robinson RC Radziejewski C Stuart DI Jones EY | 1995 | Biochemistry1995，34，13： | 1 |
| 8 | Stracture of tumor necrosis factor显示文摘 | Jones EY Stuart DI Walker NPC | 1989 | Nature1989，338，： | 1 |
| 9 | A Global Profile of Germline Gene Expression in C. elegans显示文摘 | Valerie Reinke Harold E. Smith Jeremy Nance John Wang Carrie Van Doren Rebecca Begley Steven J.M. Jones Elizabeth B. Davis Stewart Scherer Samuel Ward Stuart K. Kim | 2000 | Molecular Cell2000，，3： | 1 |
| 10 | Stracture of tumor necrosis factor显示文摘 | Jones EY Stuart DI Waiker NPC | 1989 | Nature1989，338，： | 1 |
| 11 | Does prophylactic administration of corticosteroid reduce the risk and severity of post-ERCP pancreatitis: A randomized, prospective, multicenter study显示文摘 | Stuart Sherman Urszula Blaut James L. Watkins Jeffrey Barnett Martin Freeman Joseph Geenen Michael Ryan Harrison Parker James T. Frakes Evan L. Fogel William B. Silverman Kulwinder S. Dua Giuseppe Aliperti Paul Yakshe Michael Uzer Whitney Jones John Goff | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
| 12 | Environmental management practices and engineering science: A review and typology for future research显示文摘 | Evangelinos Konstantinos I Allan Stuart Jones Keith Nikolaou Ioannis E | 2014 | Integrated Environmental Assessment and Managemen2014，，2： | 1 |
| 13 | Cell elongation and cell division in elongating lettuce hypocotyl sections显示文摘 | STUART D A DUMAM D J JONES R L | 1977 | Plant1977，135，： | 1 |
| 14 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 1 |
| 15 | Structure of tumor necrosis factor显示文摘 | Jones E Y Stuart D I Walker N P | 1989 | Nature1989，338，3： | 1 |
| 16 | Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial显示文摘 | Philip D Home Stuart J Pocock Henning Beck-Nielsen Paula S Curtis Ramon Gomis Markolf Hanefeld Nigel P Jones Michel Komajda John JV McMurray | 2009 | The Lancet2009，，9681： | 1 |
| 17 | Structure of tumor factor显示文摘 | Jones E Y Stuart D I Walker N P | 1989 | Nature1989，338，： | 1 |
| 18 | Exposure of cottonwood plants to ozone alters subsequent leaf decomposition显示文摘 | Stuart Findlay Clive G. Jones | 1990 | Oecologia1990，，2： | 1 |
| 19 | CorIJrate Brmuling in Market spaee 显示文摘 | STUART H JONES C | 2004 | Corporate Reputation Review2004，7，1： | 1 |
| 20 | Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis显示文摘 | Stuart F. W. Kendrick Graeme O’Boyle Jelena Mann Mujdat Zeybel Jeremy Palmer David E. J. Jones Chris P. Day | 2010 | Hepatology2010，，6： | 1 |
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