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| 1 | HSV-1 H129-Derived Anterograde Neural Circuit Tracers:Improvements, Production, and Applications显示文摘Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1(HSV-1) strain H129(H129), and have been successfully applied to map diverse neural circuits.Initially, the anterograde polysynaptic tracer H129-G4 was used by many groups. We then developed the first monosynaptic tracer, H129-dTK-tdT, which was highly successful, yet improvements are needed. Now, by inserting another tdTomato expression cassette into the H129-dTK-tdT genome, we have created H129-dTK-T2, an updated version of H129-dTK-tdT that has improved labeling intensity. To help scientists produce and apply our H129-derived viral tracers, here we provide the protocol describing our detailed and standardized procedures. Commonly-encountered technical problems and their solutions are also discussed in detail. Broadly, the dissemination of this protocol will greatly support scientists to apply these viral tracers on a large scale. | Hong Yang Feng Xiong Yi-Ge Song Hai-Fei Jiang Hai-Bin Qin Jing Zhou Sha Lu Steven FGrieco Xiangmin Xu Wen-Bo Zeng Fei Zhao Min-Hua Luo | 2021 | Neuroscience Bulletin2021，37，5： | 4 |
| 2 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 3 | Microstructural characterization of Ni3Al processed by reactive atomization and deposition显示文摘 | Xiaolu Zeng Steven R. Nutt Enrique J. Lavernia | 1995 | Metallurgical and Materials Transactions A1995，，4： | 1 |
| 4 | Effective optical constants n and k and extinction coefficient of silica aerogel显示文摘 | Zeng S Q Greif R Stevens P | | 0，，03： | 1 |
| 5 | Evaluation of the antigenic relatedness and cross-protective immunity of the neuraminidase between human influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus显示文摘 | Xiuhua Lu Feng Liu Hui Zeng Tiffany Sheu Jenna E. Achenbach Vic Veguilla Larisa V. Gubareva Rebecca Garten Catherine Smith Hua Yang James Stevens Xiyan Xu Jacqueline M. Katz Terrence M. Tumpey | 2014 | Virology2014，，： | 1 |
| 6 | Thermal characterization of carbon - opacified silica aerogels 显示文摘 | LEE D STEVENS P C ZENG S Q | 1995 | J of Non - Crystalline Solids1995，186，： | 1 |
| 7 | Ionizing radiation greatly improves gene transfer efficiency in mammalian cells显示文摘 | Stevens CW Zeng M Cerniglia GJ | 1996 | Hum Gene Ther1996，7，14： | 1 |
| 8 | Thermal characteriza- tion of carbon-opacified silica aerogels 显示文摘 | Lee D Stevens P C Zeng S Q | 1995 | J Non-Cryst So-lids1995，186，： | 1 |
| 9 | Effec-tive Optical Constants n and k and Extinction Coefficientof Silica Aerogel 显示文摘 | Zeng J S Q Greif R Stevens P Ayers M Hunt A | 1996 | Journal of Material Research1996，11，3： | 1 |
| 10 | Ionizing radiation greatly improves gene transfer efficiency in mammalian cells显示文摘 | Stevens CW Zeng M Cerniglia CJ | 1996 | Hum Gene Ther1996，7，： | 1 |
| 11 | Ionizing radiation greatly improves gene transfer efficiency in mammalian cells using ionizing radiation显示文摘 | Stevens CW Zeng M Cerniglia G J | 1996 | Human Gene Therapy1996，7，14： | 1 |
| 12 | Ionizing radiation greatly improves gene transfer efficiency in mammalian cells using ionizing radiation显示文摘 | Stevens CW Zeng M Cemiglia GJ | 1996 | Human Gene Therapy1996，，7： | 1 |
| 13 | Ionizing radiation greatly improves gene transfer efficiency in mammalian cells显示文摘 | Stevens CW Zeng M Cerniglia GJ | 1996 | Hum Gene Ther1996，7，14： | 1 |
| 14 | Effective optical constants n and k and extinction coefficient of silica aerogel显示文摘 | ZENG S Q GREIF R STEVENS P | 1996 | Journal of Materials Research1996，11，3： | 1 |
| 15 | Cutaneous Structural and Biochemical Correlates of Foot Complications in High-Risk Diabetes显示文摘 | Abd A. Tahrani Wei Zeng Jayadave Shakher Milan K. Piya Sharon Hughes Kiran Dubb Martin J. Stevens | 2012 | Diabetes Care2012，，9： | 1 |
| 16 | Thin-film-heater thermal conductivity apparatus and measurement of thermal conductivity of silica aerogel 显示文摘 | ZENG S Q STEVENS P C HUNT A J | 1996 | Int J Heat Mass Transfer1996，39，11： | 1 |
| 17 | Thermal characterization of carbon-opacified silica aerogels显示文摘 | Lee D Stevens P C Zeng S Q | 1995 | J of Non-Crystalline Solids1995，186，： | 1 |
| 18 | Ther- mal characterization of carbon-opacified silica aerogels 显示文摘 | Lee Daehee Stevens Peter C Zeng Shouquan | 1995 | J Non-Cryst Solids1995，186，： | 1 |
| 19 | 显示文摘 | Lee D Stevens P C Zeng S Q | 1995 | Journal of Non-Crystal Solids1995，186，： | 1 |
| 20 | Effective Optical Con stants n and k and Extinction Coefficient of Silic~ Aerogel 显示文摘 | Zeng S Q Greif R Stevens P | 1996 | J Mater Res1996，11，3： | 1 |
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