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| 1 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 2 | Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma显示文摘AIM: To investigate the survival impact of common pharmaceuticals, which target stromal interactions, following a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. METHODS: Data was collected retrospectively for 164 patients who underwent a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma(PDAC). Survival analysis was performed on patients receiving the following medications: angiotensin-converting enzyme inhibitors(ACEI)/angiotensin Ⅱ receptor blockers(ARB), calcium channel blockers(CCB), aspirin, and statins. Statistical analysis included Kaplan-meier survival estimates and cox multivariate regression; the latter of which allowed for any differences in a range of prognostic indicators between groups. Medications showing a significant survival benefit were investigated in combination with other medications to evaluate synergistic effects.RESULTS: No survival benefit was observed with respect to ACEI/ARB(n = 41), aspirin or statins on individual drug analysis(n = 39). However, the entire CCB group(n = 26) showed a significant survival benefit on multivariate cox regression; hazard ratio(HR) of 0.475(CI = 0.250-0.902, P = 0.023). Further analysis revealed that this was influenced by a group of patients who were taking aspirin in combination with CCB; median survival was significantly higher in the CCB + aspirin group(n = 15) compared with the group taking neither drug(n = 98); 1414 d vs 601 d(P = 0.029, logrank test). Multivariate cox regression revealed neither aspirin nor CCB had a statistically significant impact on survival when given alone, however in combination the survival benefit was significant; HR = 0.332(CI = 0.126-0.870, P = 0.025). None of the other medications showed a survival benefit in any combination.CONCLUSION: Aspirin + CCB in combination appears to increase survival in patients with PDAC, highlighting the potential clinical use of combination therapy to target stromal interactions in pancreatic cancer. | Samuel J Tingle John A Moir Steven A White | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 2 |
| 3 | Remote Ischemic Conditioning Reduces Myocardial Infarct Size and Edema in Patients With ST-Segment Elevation Myocardial Infarction显示文摘 | Steven K. White Georg M. Frohlich Daniel M. Sado Viviana Maestrini Marianna Fontana Thomas A. Treibel Shana Tehrani Andrew S. Flett Pascal Meier Cono Ariti John R. Davies James C. Moon Derek M. Yellon Derek J. Hausenloy | 2014 | JACC: Cardiovascular Interventions2014，，： | 1 |
| 4 | Generating surfaces of daily meteorological variables over large regions of complex terrain 显示文摘 | Peter E Thornton Steven W Running Michael A White | 1997 | Journal of Hydrology1997，190，： | 1 |
| 5 | 地氟烷与七氟烷在门诊手术全身麻醉维持中的对比研究:对苏醒早晚期及围手术期咳嗽的影响显示文摘背景目前地氧垸已经用于门诊全身麻醉手术的维持阶段,其相对于七氖烷在围手术期的优略性尚存争议。尽管各研究一致指出,地氟烷比七氟烷苏醒更快,但这种差异对苏醒晚期的影响却未有明确报道。并且,地氟烷与七氟烷相比,对咳嗽发生率的影响也存在争议。方法本研究中纳入了130例在全身麻醉下行浅表门诊手术的患者,随机分为2组。所有患者都静脉注射丙泊酚2mg/kg诱导,置入喉罩,采用1%-3%的七氟烷或3%-8%的地氟炕维持麻醉,吸入混合空气或氧气。调节吸入麻醉药的浓度,维持血流动力学稳定,并维持脑电双频谱指数(BIS)于50—60。并用局部浸润和静脉注射酮洛酸30mg镇痛。在手术结束时给予预防性止吐药物,包括昂丹司琼4mg、地塞米松4mg及甲氧氨普胺10mg。评估标准包括睁眼恢复时间,对指令做出反应的时间,定向力恢复的时间,14分快通道评分,首次进食时间,能坐立,可站立,独立行走及出院时间。手术后早期及离院后24小时内,记录患者对于麻醉的满意度,手术后第1天恢复正常活动的能力,不良反应的发生(如咳嗽、意向性运动、氧饱和度〈90%、咽痛及手术后恶心、呕吐),手术后镇痛药及止吐药的使用情况。结果2组患者的流行病学资料相近。尽管围手术期地氯烷组咳嗽的总体发生率高于七氟烷组(分别为60%和32%,P〈0.05),然而在真正应用吸入麻醉药期间(即麻醉维持中),咳嗽发生率的组间差异无显著性。地氧烷组患者苏醒较快,但两组所有患者在离开手术室之前都达到了快通道恢复标准(快通道评分≥12)。此外,离院时间(七氟炕组90±31分钟,地氟炕组98±5分钟)及手术后第1天能恢复正常活动的患者比率(七氟烷48%,地氟炕60%),在两组间的差异无显著性。结论用地氧烷进行维持全身麻醉具有苏醒迅速、咳嗽发生率高的特点。尽管与七氟烷相比,地氟炕在麻醉早期恢复较快,但两组晚期恢复的差异无显著性。两种吸入麻醉药都适用于门诊手术的麻醉。 | Paul F. White Jun Tang Ronald H. Wender Roya Yumul O. lameson Stokes Alexander Sloninsky Robert Naruse Robert Kariger Evelyn Norel Steven Mandel Tom Webb Alan Zaentz 王琦(译) 李文志(校) | 2011 | 麻醉与镇痛2011，7，1： | 1 |
| 6 | Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin显示文摘 | Heyn H White RB Stevens Jc | 1996 | Drug Metab Dispos1996，24，： | 1 |
| 7 | Effect of propofol on the incrednce of postoperative Vomiting after strabfismus surgery in pediatric outpatients显示文摘 | Wateh MF simeon RM White PF stevens JL | 1991 | Anesthesiotogy1991，72，： | 1 |
| 8 | An Exploration into Regional Variation in Innovative Activity in China 显示文摘 | Xielin Liu Steven White | 2001 | Technology Management2001，21，12： | 1 |
| 9 | Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation显示文摘 | Minchenko AG Stevens MJ White L | 2003 | FASEB J2003，17，： | 1 |
| 10 | A survey of Chinese lit- erature on the management of technology and innovation : 1987 - 1997 显示文摘 | Steven White Xielin Liu Wei Xie | 2001 | Intematlonal Journal of Technology Management2001，21，12： | 1 |
| 11 | Sequential learning in a Chinese spin-off显示文摘 | Xie Wei White Steven | 2004 | R&D Management2004，34，2： | 1 |
| 12 | Involvement of GATA3 in protein kinase C theta-induced Th2 cytokine expression显示文摘 | Stevens L Htut TM White D | 2006 | Immunol2006，36，12： | 1 |
| 13 | An exploration into regional variation in innovative activity in China显示文摘 | Steven White | 2001 | Journal of Technology Management2001，21，12： | 1 |
| 14 | Reactive lymphoid hyperplasia of the liver and pancreas. A report of two cases and a comprehensive review of the literature显示文摘 | Aimen Amer Sebastian Mafeld Danish Saeed Wissam Al-Jundi Beate Haugk Richard Charnley Steven White | 2011 | Clinics and Research in Hepatology and Gastroenterology2011，，4： | 1 |
| 15 | Automated hexahedral mesh generation by generalized multiple source to multiple target sweeping显示文摘 | Mingwu Lai Steven Benzley David White | 2000 | International Journal for Numerical Methods in Engineering2000，49，27： | 1 |
| 16 | CCSweep:antomatic decomposition of multi-sweep volumes显示文摘 | David R White Sunil Saigal Steven J Owen | 2004 | Engineering with Computers2004，20，3： | 1 |
| 17 | Soil moisture effects on uptake of metals by Thlaspi, Alyssum, and Berkheya显示文摘 | J. Scott Angle Alan J. M. Baker Steven N. Whiting Rufus L. Chaney | | 0，2003，： | 1 |
| 18 | Adolescence-limited versus persistent delinquency:Extending Moffitt' s hypothesis into adulthood显示文摘 | Raskin White Helene Bates Marsha E Buyske Steven | | 0，，04： | 1 |
| 19 | Controllable Surface Modification of Poly(lactic-co glycolie acid) (PLGA) by Hydrolysis or Aminolysis I: Physical, Chemical, and Theoretical Aspects显示文摘 | Croll TI O' Connor AJ Stevens GW Cooper White JJ | 2004 | Biomacromolecules2004，5，： | 1 |
| 20 | Diabetes-induced over-experession of endothelin-I and endothelin receptors in the rat renal cortex is mediated via poly(ADP-fibose) polymerase activation显示文摘 | Minchenko AG Stevens M J White L | 2003 | FASEB J2003，17，11： | 1 |
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