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| 1 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 2 | Pelvic lipomatosis associated with cystitis glandularis and adenocarcinoma of the bladder显示文摘 | HEYNS C F KOCK D E KIRSTEN P H | 1991 | J Urol1991，145，2： | 1 |
| 3 | Primary non-Hodgkin's lymphoma of bone: a clinicopathological investigation of 60 cases显示文摘 | Heyning F H Hogendoorn P C Kramer M H | 1999 | Leukemia1999，13，： | 1 |
| 4 | Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin显示文摘 | Heyn H White RB Stevens Jc | 1996 | Drug Metab Dispos1996，24，： | 1 |
| 5 | Chromophore reorientation during the photocycle of bacteriorhodopsin experimental methods and functional significance显示文摘 | Borucki B Otto H | 2000 | Biochimica Biophysica Acta2000，1460，： | 1 |
| 6 | Reconstruction of road defects and road roughness classification using vehicle responses with artificial neural networks simulation显示文摘 | Ngwangwa H M Heyns P S Labuschagne F J J | 2010 | Journal of Terramechanics2010，47，2： | 1 |
| 7 | The origin and development of cytoplasmic male sterile Chinese cabbage, Proceeding of the First International Symposium显示文摘 | Williams P H Heyn F W | 1981 | Taiwan: Asian Vegetable Research and Development Center1981，，： | 1 |
| 8 | MR imaging characteristics in primary lymphoma of bone with emphasis on non-aggressive appearance显示文摘 | Heyning F H Kroon H M Hogendoorn P C | 2007 | Skeletal Radiol2007，36，10： | 1 |
| 9 | Distinct DNA methylomes of newborns and centenarians显示文摘 | Heyn H Li N Ferreira H J | 2012 | Proc Natl Acad Sci2012，109，10： | 1 |
| 10 | Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin显示文摘 | COOLENS J L VAN BAELEN H HEYNS W | 1987 | J Steroid Biochem1987，26，2： | 1 |
| 11 | Whole -genome bisulfite DNA sequencing of a DNMT3B mutant patient显示文摘 | Heyn H Vidal E Sayols S | 2012 | Epigenetics2012，7，6： | 1 |
| 12 | MicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer developm- ent显示文摘 | Heyn H Engelmann M Schreek S | 2011 | Int J Cancer2011，，12： | 1 |
| 13 | Reconstruction of Road Defects and Road Roughness Classification Using Artificial Neural Networks Simulation and Vehicle Dynamic Re- sponses: Application to Experimental Data 显示文摘 | Ngwangwa H M Heyns P S Breytenbach H G A | 2014 | Journal of Terramechanics2014，53，： | 1 |
| 14 | Validation of a DNA methylation microarray for 450 000 CpG sites in the human genome显示文摘 | Sandoval J Heyn H Moran S | 2011 | Epigenetics2011，6，6： | 1 |
| 15 | MicroRNA miR-335 is cruci- al for the BRCA1 regulatory cascade in breast cancer development 显示文摘 | Heyn H Engelmann M Schreek S | 2011 | Int J Cancer2011，129，12： | 1 |
| 16 | Nutrient cycling and soil fertility in thegrazed pasture ecosystem显示文摘 | HEYNES R J William P H | 1993 | Advance Agronogy1993，49，： | 1 |
| 17 | Reconstruction of Road Defects and Road Roughness Classification Using Vehicle Responses with Artificial Neural Networks Simulation 显示文摘 | Ngwangwa H M Heyns P S | 2010 | Journal of Terrame chanics2010，47，： | 1 |
| 18 | Development of a tool wear-monitoring system for hard turning显示文摘 | S cheffer C Kratz H Heyns P S | 2003 | International Journal of Machine Tools & Manufacture2003，43，10： | 1 |
| 19 | Resistanceto tobacco mosaic virus in capsicum with reference tothe Sansun latent strain显示文摘 | Greenleaf W H Cook A A Heyn A N J | 1964 | Phyto Pathology1964，，54： | 1 |
| 20 | Oral immunisation of wild boar against classical swine fever: concluding analysis of the recent field trials in Germany显示文摘 | Kaden V Heyne H Kiupel H | 2002 | Berl Munch Tierarztl Wochenschr2002，115，56： | 1 |
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