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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Osmotic demyelination syndrome following correction of hyponatremia显示文摘 | Sterns RH Riggs JE Schochet SS Jr | 1986 | N Engl J Med1986，314，24： | 1 |
| 3 | Simultaneous EEG and fMRI of the alpha rhythm显示文摘 | Goldman RI Stern JM Engel J Jr | 2002 | Neuroreport2002，13，： | 1 |
| 4 | Osmotic demyelination syndrome following correction of hyponatremia显示文摘 | Sterns RH Riggs JE Schochet SS Jr | 1986 | N Engl J Med1986，314，： | 1 |
| 5 | Pre-emptiveimmunotherapy with purified natural killer cells after haploidenticalSCT: a prospective phase D study in two centers 显示文摘 | Stern M Passweg JR Meyer-Monard S | 2013 | Bone MarrowTransplantation2013，48，3： | 1 |
| 6 | Preemptive immunotherapy with purified natural killer cells after haploidentical SCT:aprospective phase II study in two centers显示文摘 | Stern M Passweg JR Meyer-Monard S | 2012 | Bone Marrow Transplant2012，48，： | 1 |
| 7 | Natural ammonium illites from black shales hosting a stratiform base metal deposit, Delong Mountains, Northern Alaska 显示文摘 | Sterne E J Reynold R C Jr | 1982 | Clays and Clay Minerals1982，30，3： | 1 |
| 8 | Oxygen isotope evidence of climate change from pedogenic clay minerals in the Himalayan molasse显示文摘 | Stern L A Chamberlain C P Reynolds R C Jr | 1997 | Geochimica et Cosmochimica Acta1997，61，： | 1 |
| 9 | Hematological changes following amaru- thon race in male and female runners显示文摘 | Wells CL Stern JR Hecht LH | 1982 | Eur J Appl Physiol Occup Physiol1982，48，1： | 1 |
| 10 | Diagnosis and successful medical treatment of Acanthamoeba keratitis显示文摘 | D'Aversa G Stern GA Driebe WT Jr | 1995 | Arch Ophthalmol1995，113，9： | 1 |
| 11 | Subclinical hypothyroidism: a modifiable risk factor for depression? 显示文摘 | Haggerty JJ Jr Stern RA Mason GA | 1993 | Am J Psychiatry1993，150，3： | 1 |
| 12 | Effect of troglitazone on the pharmacokinetics of an oral contraceptive agent显示文摘 | Loi CM Stern R Koup JR | 1999 | J Clin Pharmacol1999，39，4： | 1 |
| 13 | The influence of anxiety and depression on outcomes of patients with coronary artery disease显示文摘 | Januzzi JL Jr Stern TA Pasternak RC | 2000 | Arch Intern Med2000，160，13： | 1 |
| 14 | Pitch and heave test and uncertainty assessment for a surface combatant in regula waves显示文摘 | IRVINE JR M LONGO J STERN F | 2008 | Journal of Ship Research2008，52，2： | 1 |
| 15 | Circadian rhythm of plasma rennin activity in older normal and essential hypertensive men:relation with inactive renin,aldosterone,cortisol and REM sleep显示文摘 | Stern N Sowers JR McGinty D | 1986 | J Hypertens1986，4，： | 1 |
| 16 | Role of bronchial artery embolization in management of hemoptysis显示文摘 | Fermando HC Stern M Benfield JR | 1998 | Arch Surg1998，133，： | 1 |
| 17 | Pitch and heave tests and uncertainty assessment for a surface combatant in regular waves显示文摘 | RVINE Jr M LONGO J STERN F | | 0，，： | 1 |
| 18 | Simultaneous EEG and fMRI of the alpha rhythm显示文摘 | GOLDMAN R I STERN J M JR J E | 2002 | Neuro Report2002，13，： | 1 |
| 19 | lJlepharochalasis 显示文摘 | Collin JR Beard C Stern WH | 1979 | Br J Oph- thalmol1979，63，8： | 1 |
| 20 | Procedural and strain related variables significantly affect outcome in a murine rood el of focal cerebral ischemia 显示文摘 | Connotly ES Jr Winfree CJ Stern DM | 1996 | Neurosurgery1996，38，3： | 1 |
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