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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Intraepithelial sebaceous carcinoma of the conjunctiva and skin of the eyelid 显示文摘 | Margo CE Lessner A Stern GA | 1992 | Ophthalmology1992，99，2： | 1 |
| 3 | Histopathology of meibomian gland dys- function 显示文摘 | Gutgesell VJ Stern GA Hood CI | 1982 | Am J Ophthalmol1982，94，： | 1 |
| 4 | Histopathology of meibomian gland dysfunction 显示文摘 | Gutgesell VJ Stern GA Hod CI | 1982 | Am J Ophthalmol1982，94，3： | 1 |
| 5 | Diagnosis and successful medical treatment of Acanthamoeba keratitis显示文摘 | D'Aversa G Stern GA Driebe WT Jr | 1995 | Arch Ophthalmol1995，113，9： | 1 |
| 6 | Subclinical hypothyroidism: a modifiable risk factor for depression? 显示文摘 | Haggerty JJ Jr Stern RA Mason GA | 1993 | Am J Psychiatry1993，150，3： | 1 |
| 7 | Endothelial cells in physiology and in the pathophysiology of vascular disorders 显示文摘 | Pollak ES Buck CA Loscalzo J Zimmerman GA McEver RP Pober JS Wick TM Konkle BA Schwartz BS Barnathan ES McCrae KR Hug BA Schmidt AM Stern DM | 1998 | Blood1998，91，10： | 1 |
| 8 | Results of therapeutic penetrating keratoplasty显示文摘 | Killingsworth DW Stern GA Driebe WT | 1993 | Ophthalmology1993，100，4： | 1 |
| 9 | The sex-specific association of serum OPG and RANKL with bone mineral density in older adults: the rancho bernardo study 显示文摘 | Stern A Laughlin GA Bergstrom J | 2007 | Eur J Endocrinol2007，156，5： | 1 |
| 10 | Three dimen-sional imaging of the thoracic cavity 显示文摘 | Stern RL Cline HE Johnsor GA | 1989 | Investigat Ra-dial1989，24，12： | 1 |
| 11 | The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor kappaB legend with bone mineal density in order adults:the Rancho Bermardo study显示文摘 | Stern A Laughlin GA Bergstrom J | 2007 | Eur J Endocrinol2007，156，5： | 1 |
| 12 | The sex-specific association of semm osteoprotegerin and receptor activator of nuclear factor kappa B legend with bone nfineral density in older adults:the Rancho Bemardo study显示文摘 | Stern A Laughlin GA Bergstrom J | 2007 | Eur J Endocrinol2007，156，5： | 1 |
| 13 | Treatment of alkali-injured rabbit come as with a synthetic inhibitor of matrix metallopmteinases 显示文摘 | Schuhz GS Strelow S Stern GA | 1992 | Invest Ophthalmol Vis Sci1992，33，12： | 1 |
| 14 | Influences on attitude-behavior relationships: A natural experiment with curbside recycling显示文摘 | Guagnano GA Stern P C Dietz T | 1995 | Environment and Behavior1995，，27： | 1 |
| 15 | The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor kappa B legend with bone mineral density in older adults:the Rancho Bernardo study显示文摘 | Stern A Laughlin GA Bergstrom J | 2007 | Eur J Endocrinol2007，156，5： | 1 |
| 16 | Persistent organic pollutants (POPs) in a small, herbivorous, arctic marine zooplankton (Calanus hyperboreus) : Trends from April to July and influence of lipids and trophic transfer显示文摘 | Fisk AT Stern GA Hobson KA | 2001 | Mar Pollut Bull2001，43，16： | 1 |
| 17 | Intraepithelial sebaceous carcinoma of the conjunctiva and skin of the eyelid显示文摘 | Margo CE Lessner A Stern GA | 1992 | Ophthalmology1992，99，： | 1 |
| 18 | Subclinical hypothyroidism : a modifiable risk factor for depression? 显示文摘 | Haggerty JJ Jr Stern RA Mason GA et d | 1993 | Am J Psychiatry1993，150，3： | 1 |
| 19 | Histopathology of meibomi-angland dysfunction显示文摘 | Gutgese11 VJ Stern GA Hood CI | 1982 | Am J Ophthalmol1982，94，3： | 1 |
| 20 | Effect of pterygium excision on induced corneal topographic abnormalities显示文摘 | Stern GA Lin A | 1998 | Cornea1998，17，1： | 1 |
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