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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion显示文摘 | BOYD RA STERN RH STEWART BH | 2000 | J Clin Pharmaco12000，40，1： | 1 |
| 3 | p185, a product of the neu proto-oncogene,is a receptorlike protein associated with tyrosine kinase activity显示文摘 | Hefferman PA Weinberg RA | 1986 | Mol Bell Biol1986，6，5： | 1 |
| 4 | Diagnosing pulmonary alveolar proteinosis:a review and an update显示文摘 | Wang BW Stern EJ Schmidt RA | 1997 | Chest1997，111，： | 1 |
| 5 | Use of thyroid hormone to diminish the cognitive side effects of psychiatric treatment显示文摘 | Stern RA | 1997 | Psychopharmacol Bull1997，33，2： | 1 |
| 6 | Atorvastatin coad-ministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion显示文摘 | Stern RH Stewart BH | 2000 | Clin Pharmacol2000，40，1： | 1 |
| 7 | Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion显示文摘 | Boyd RA Stern RH Stewart BH | 2000 | J Clin Pharmacol2000，40，1： | 1 |
| 8 | Obesity, body fat distribution and sex hormones in men显示文摘 | Haffner SM Valdez RA Stern MP | 1993 | Int J Obes Relat Metab Disord1993，17，11： | 1 |
| 9 | Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein- mediated secretion 显示文摘 | Boyd RA Stern RH Steward BH | 2000 | J Clin Pharmacol2000，40，： | 1 |
| 10 | Diagnosing pulmonary alveolar proteinosis显示文摘 | Stern EJ Schmidt RA | 1997 | Chest1997，111，2： | 1 |
| 11 | Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal Pglycoprotein -mediated secretion 显示文摘 | Boyd RA Stern RH Stewart BH | 2000 | J Clin Pharmacol2000，40，： | 1 |
| 12 | Subclinical hypothyroidism: a modifiable risk factor for depression? 显示文摘 | Haggerty JJ Jr Stern RA Mason GA | 1993 | Am J Psychiatry1993，150，3： | 1 |
| 13 | Diagnosing pulmonary alverolar proteinosis: A review and an update显示文摘 | Wang BM Stern EJ Schmidt RA | 1997 | Chest1997，111，： | 1 |
| 14 | Predicting diabetes, moving beyond impaired glucose tolerance显示文摘 | Stern MP Morales PA Valdez RA | 1993 | Diabetes1993，42，5： | 1 |
| 15 | Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion 显示文摘 | BOYD RA STERN RH STEWART BH | 2000 | J Clin Pharmacol2000，40，1： | 1 |
| 16 | Measurement of mood states in stroke patients: validation of the visual analog mood scales 显示文摘 | Arruda JE Stern RA Somerville JA | 1999 | Arch Phys Med Rehabil1999，80，6： | 1 |
| 17 | Diagnosing pulmonary alveolar proteinosis:a review and an update显示文摘 | Stern EJ Schmidt RA | 1997 | Chest1997，111，4： | 1 |
| 18 | Congenitally corrected transposition of the great arteries and concomitant coronary artery and valvular disease in the adult patient显示文摘 | Stern DR Steiner C Bello RA | | 0，，： | 1 |
| 19 | Diagnosing pulmonary alveolar proteinosis, A review and updater显示文摘 | Wang BM Stern FJ Schmidt RA | 1977 | Chest1977，111，： | 1 |
| 20 | Measurement of mood states in stroke patients:validation of the visual analog mood scales显示文摘 | Arruda JE Stern RA Somerville JA | 1999 | Arch Phys Med Rehabil1999，80，： | 1 |
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