|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 4 | Overexpression of human cardiac troponin I and troponin-C in Escherichia coli and their purification 显示文摘 | Eman A Stephen D Ian P | 1994 | Eur J Biochem1994，225，： | 2 |
| 5 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 6 | Chemical Coal Cleaning Using Selective Oxidation显示文摘 | Stephen R P Edwin J H Xavier A D | 1994 | Fuel1994，73，2： | 1 |
| 7 | Consequences of the Allee effect for behaviour, ecology and censer?vation显示文摘 | Stephens P A Sutherland W J | 1999 | Trends in Ecology and Evolution1999，14，10： | 1 |
| 8 | Dispersion compensation over 270km at 10 Gbit/s using an offset-core chirped fiber Bragg gratings显示文摘 | Krug P A Stephens T Offe G Y | 1995 | Electrionics Letters1995，31，13： | 1 |
| 9 | The epidemiology of hearing problems:How should we investigate it? 显示文摘 | Stephens D Lewis P Davis A | 2004 | Acta Otolaryngol2004，552，1： | 1 |
| 10 | Chemically modified,screen-printed carbon electrodes 显示文摘 | Stephen A Wring John P Hart | 1992 | Analyst1992，117，： | 1 |
| 11 | Association mapping in structured populations 显示文摘 | Pritchard J K Stephens M Rosenberg N A DonneUy P | 2000 | The American Journal of Human Genetics2000，67，1： | 1 |
| 12 | Enforced stacking in crowded arenes显示文摘 | Bushey M L Hwang A Stephens P W | 2001 | J Am Chem Soc2001，123，： | 1 |
| 13 | Genotyping of peach and nectarine cultivars with SSR and SRAP molecular marker显示文摘 | Riaz A Dan P Stephen M S | 2004 | Journal of the American Society for Horticultural Science2004，129，2： | 1 |
| 14 | Consequences of the Allee effect for behaviour, ecology and conservation显示文摘 | Stephens P A Sutherland W J | 1999 | Trends in Ecology and Evolution1999，14，： | 1 |
| 15 | Recent developments in the design and application of screen-printed electrochemical sensors for biomedical, environmental and industrial analyses 显示文摘 | John P Hart Stephen A Wring | 1997 | Trends in Analytical Chemistry1997，16，2： | 1 |
| 16 | The consequences of chirality in crowded arenes-macromolectdar helieity,hierarchical ordering,and directed assembly显示文摘 | Bushey M L Hwang A Stephens P W | 2002 | Angew Chem Int Ed2002，41，： | 1 |
| 17 | Effects of repeated prenatal ultrasound examinations on childhood outcome up to 8 years of age: follow-up of a randomised controlled trial显示文摘 | John P Newnham Dorota A Doherty Garth E Kendall Stephen R Zubrick | 2004 | Lancet2004，364，9450： | 1 |
| 18 | Outsourcing and industrial decline 显示文摘 | RICHARD A BETYIS STEPHEN P BRADLEY GARY HAMEL | 1992 | The Executive1992，6，1： | 1 |
| 19 | Coping style as a psychological resource of grateful people显示文摘 | Alex M W Stephen J Linley A P | 2007 | Journal of Social and Clinical Psychology2007，26，9： | 1 |
| 20 | The patterns and dynamics of genomic instability in metastatic pancreatic cancer显示文摘 | Campbell P J Yachida S Mudie L J Stephens P J Pleasance E D Stebbings L A | 2010 | Nature2010，467，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员